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| 1 | Micromolar sodium fluoride mediates anti-osteoclastogenesis in Porphyromonas gingivalis-induced alveolar bone loss显示文摘Osteoclasts are bone-specific multinucleated cells generated by the differentiation of monocyte/macrophage lineage precursors.Regulation of osteoclast differentiation is considered an effective therapeutic approach to the treatment of bone-lytic diseases.Periodontitis is an inflammatory disease characterized by extensive bone resorption. In this study, we investigated the effects of sodium fluoride(Na F) on osteoclastogenesis induced by Porphyromonas gingivalis, an important colonizer of the oral cavity that has been implicated in periodontitis. Na F strongly inhibited the P. gingivalis-induced alveolar bone loss. That effect was accompanied by decreased levels of cathepsin K, interleukin(IL)-1β, matrix metalloproteinase 9(MMP9), and tartrate-resistant acid phosphatase,which were up-regulated during P. gingivalis-induced osteoclastogenesis. Consistent with the in vivo anti-osteoclastogenic effect,Na F inhibited osteoclast formation caused by the differentiation factor RANKL(receptor activator of nuclear factor kB ligand)and macrophage colony-stimulating factor(M-CSF). The RANKL-stimulated induction of the transcription factor nuclear factor of activated T cells(NFAT) c1 was also abrogated by Na F. Taken together, our data demonstrate that Na F inhibits RANKL-induced osteoclastogenesis by reducing the induction of NFATc1, ultimately leading to the suppressed expression of cathepsin K and MMP9.The in vivo effect of Na F on the inhibition of P. gingivalis-induced osteoclastogenesis strengthens the potential usefulness of Na F for treating periodontal diseases. | Ujjal K Bhawal Hye-Jin Lee Kazumune Arikawa Michiharu Shimosaka Masatoshi Suzuki Toshizo Toyama Takenori Sato Ryota Kawamata Chieko Taguchi Nobushiro Hamada Ikuo Nasu Hirohisa Arakawa Koh Shibutani | 2015 | International Journal of Oral Science2015，7，4： | 3 |
| 2 | Analysis of essential carboxylic amino acidresidues for catalytic activity of fungal chitosanases by site- directed mutagenesis 显示文摘 | SHIMOSAKA M SATO K NISHIWAKI N | 2005 | Journal of Bioscience and Bioengineering2005，100，5： | 1 |
| 3 | Distributed workflow management system based on publish-subscribe notification for Web Services显示文摘 | Hisashi Shimosaka Tomoyuki Hiroyasu Mitstmori Miki | 2007 | New Generation Computing2007，25，4： | 1 |
| 4 | Study on the for marion of periodic ridges on the rubber surface by friction and wear monitoring 显示文摘 | T Iwai Y Uchiyama K Shimosaka | 2005 | Wear2005，259，16： | 1 |
| 5 | Estimation of bulk density distribution in particle charging process using discrete element method considering particle shape显示文摘 | AKASHI M MIO H SHIMOSAKA A | 2008 | ISIJ International2008，48，11： | 1 |
| 6 | Molecular cloning of the N-acetylneuraminate lyase genein Escheriehia coli K-12 显示文摘 | Ohta Y Shimosaka M Murata K | 1986 | Applied Microbiology and Biotechnology1986，24，： | 1 |
| 7 | Cloning and sequencing of a full length cDNA coding for phenylalanine ammonia-lyase from tobacco cell culture显示文摘 | Nagai N Kitauchi F Shimosaka M | 1994 | Plant Physiology1994，84，3： | 1 |
| 8 | Cloning and sequencing of a full-length cDNA coding for phenylalanine ammonialyase from tobacco cell culture显示文摘 | Nagai N Kitauchi F Shimosaka M | | 0，，03： | 1 |
| 9 | Valence band photoemission study of the copper chalcogenide compounds,Cu2S,Cu2Se and Cu2Te显示文摘 | Kashida S Shimosaka W Mori M | 2003 | Journal of Physics and Chemistry of Solids2003，64，12： | 1 |
| 10 | Fabrication of polyester microchannels and their applications to capillary electrophoresis 显示文摘 | XU W UCHIYAMA K SHIMOSAKA T | 2001 | J Chromatogr: A2001，907，： | 1 |
| 11 | Molecular cloning and characterization of a chitosanase from the chitosanolytic bacterium Burkholderia gladioli strain CHB101 显示文摘 | Shimosaka M Fukumori Y Zhang XY | 2000 | Appl Microbiol Biotechnol2000，54，： | 1 |
| 12 | Fabrication of polyester microchannals and their applications to capillary electrophoreis显示文摘 | Uchiyama K Shimosaka T | 2001 | J Chromatogr A2001，907，： | 1 |
| 13 | Monitoring of dye adsorption phenomena at a silica glass/water interface with total internal reflection thermal prismatic spectrum 显示文摘 | Shimosaka T SugiiT HoboT | 2000 | AnalChem2000，72，14： | 1 |
| 14 | Analysis of separation characteristics of rotating probability screen 显示文摘 | Ishikawa S Shimosaka A | 2006 | Journal of Chemical Engi- neering of Japan2006，39，6： | 1 |
| 15 | Experimental and theoretical approaches to charging behavior of polymer particles显示文摘 | YOSHIDA M LI N SHIMOSAKA A | 2006 | Chemical Engineering Science2006，61，7： | 1 |
| 16 | Modeling of solid par-ticle flow in blast furnace considering actual operation by large-scale discrete element method显示文摘 | Mio H Yamamoto K Shimosaka A | | 0，，12： | 1 |
| 17 | Fabrication of an integrated PDMS microchip incorporating an LED-induced fluorescence device显示文摘 | MIYAKI K GUO Y SHIMOSAKA T | 2005 | Analytical and Bioanalytical Chemistry2005，382，3： | 1 |
| 18 | Highly sensitive method for trace gas ana- lysis显示文摘 | Shimosaka T | 2008 | Bunseki Kagaku2008，57，9： | 1 |
| 19 | Study on the Formation of Periodic Ridges on the Rubber Surface by Friction and Wear Monitoring显示文摘 | Iwai T Uchiyama Y Shimosaka K | 2005 | Wear2005，259，66： | 1 |
| 20 | Tissue expression map of a large number of expressed sequence tags and its application to in silico screening of stress response genes in common wheat 显示文摘 | Mochida K Kawaura K Shimosaka E Kawakami N Shin-I T Kohara Y Yamazaki Y Ogihara Y | 2006 | Molecular Genetics and Genomics2006，276，3： | 1 |
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