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146篇 您的检索式：作者名="Sheppard N"

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	题名	作者	年代	出处	被引量
1	Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis显示文摘变化 F508del 是基因疾病的最普通的原因膀胱的纤维变性(CF ) 。CF 在身体破坏许多机关的函数,最尤其是肺,由使不安,盐和水搬运到对面上皮的表面。F508del 以二个主要方法引起伤害。首先,变化阻止膀胱的纤维变性 transmembrane 传导力管理者(CFTR ) 的交货到它的正确细胞的地点,顶端(面对腔) 上皮的房间的膜。第二, F508del 使不安由破坏隧道 gating 的 CFTR 的 Cl ⁻ 隧道功能。这里,我们为 CF 讨论合理新治疗的发展那目标 F508del-CFTR。我们加亮结构的研究怎么由 ATP 绑定和水解作用的周期在隧道 gating 的规定提供新卓见进 F508 的角色。我们强调为治疗开发识别铅混合物的高产量的屏蔽的使用。这些混合物包括在救 F508del-CFTR gating 缺点的上皮的房间和 CFTR potentiators 的顶端的膜恢复 F508del-CFTR 的表示的 CFTR 修正者。从 CFTR 修正者和 potentiators 的临床的试用的起始的结果预示指向 CF 的根原因的小分子治疗的发展顺利:在 CFTR 的变化。	Zhi-wei CAI Jia LIU Hong-yu LI David N SHEPPARD	2011	Acta Pharmacologica Sinica2011，32，6：	2
2	查看详情显示文摘	Singh J Teo J H S Xu Y Premachandran C S Chen N Kotlanka R Olivo M Sheppard C J R		0，，：	1
3	Biodegradation of aromatic hydrocarbons in crudes oils from the Barrow Sub-basin of Western Australia显示文摘	Volkman J K Alexander R Kagi R I Rowland S J Sheppard P N	1984	Org Geochem1984，6，62：	1
4	A Study of the Hydrogen Distribution in Coal-like Materials by High-resolution Nuclear Magnetic Resonance Spec- tropcopy I The Measurement and Interpretation of the Spectra显示文摘	Brown J K Lander W R Sheppard N	1960	Fuel1960，39，1：	1
5	Aetiology of sudden cardiac death in sport: a histopathologist's perspective显示文摘	Mary N Sheppard	2012	Br J Sports Med2012，46，：	1
6	The infrared spectrum and structure of boric acid 显示文摘	Bethell D E Sheppard N	1955	Transactions of the Faraday Society1955，51，：	1
7	Structural correlations in the nuclear magnetic resonance spectra of bisbenzylisoquinoline and aporphine alkaloids显示文摘	Harley-Mason J Sheppard N	1961	J Chem Soc1961，5，：	1
8	Effect of pre-and post veraison smoke exposure on guaiacol and4-methylguaiacol concen-tration in mature grapes显示文摘	SHEPPARD S I DHESI M K EGGERS N J	2009	American Journal of Enology and Viti-culture2009，60，1：	1
9	The importance of early season phosphorus nutrition显示文摘	Grant C A Flaten D N Tomasiewicz D J Sheppard S C	2001	Canadian Journal Plant Science2001，，81：	1
10	Expression of the beta6 integrin subunit is associated with sites of neutrophil influx in lung epithelium显示文摘	BARNETT N L SHEPPARD D	2001	J Histochem Cytochem2001，49，1：	1
11	Dual responsive promoters to target therapeutic gene expression to radiation-resistant hypoxia tumor cells显示文摘	Chadderon N Cowen RL Sheppard FC	2005	Int J Radiat Oncol Biol phys2005，62，1：	1
12	Corrosion resistance of A1 - Li alloys 显示文摘	Sheppard T Parson N C	1987	Materials Science and Technology1987，3，5：	1
13	Microstructural development during annealing of hot rolled Al-Mg alloys显示文摘	Sheppard T	1986	Materials Science and Teehonology1986，6，：	1
14	Reversible Hydrogen Chemlsorption at Near-ambient Temperatures and Pressures on Unsaturated and Aromatic Hydrocarbon Complexes with Finely Divided Metals显示文摘	Davydov V Y Sheppard N Osawa E	2004	Int J Hydrogen Energy2004，29，11：	1
15	Prospective study of elective bilateral versus unilateral femoral arterial puncture for uterine artery embolization显示文摘	Bratby MJ Bamachandran N Sheppard N	2007	Cardiovasc Intervent Radiol2007，30，6：	1
16	Concentrating solar thermal heat storage using metal hydrides显示文摘	Harries D N Paskevicius M Sheppard D	2012	Proceedings of the IEEE2012，100，2：	1
17	Isotopic fractionation of Cu and Zn between chloride and nitrate solutions and malachite or smithsonite at 30 ℃ and 50 ℃ 显示文摘	Marechal C N Sheppard S M F	2002	Geochimica et Cosmo- ehimica Acta2002，66，15：	1
18	The rat probasin gene promoter directs hormonally and developmentally regulated expression of a heterologous gene specifically to the prostate in transgenic mice显示文摘	GREENBERG N M DEMAYO F J SHEPPARD P C	1994	Mol Endocrinol1994，8，2：	1
19	Biodegradation of aromatic hydrocarbons in crude oils from Banow subbasin of Western Australia显示文摘	Volkman J K Alexander R Kagi R L Rowland S J Sheppard P N	1984	Org Geochem1984，6，：	1
20	The impact of sludge amendment on gas dynamics in an upland soil:monitored by membrane inlet mass spectrometry Original Research Article显示文摘	Sheppard S K Gray N Head I M	2005	Bioresource Technology2005，96，10：	1

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