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您的检索式：作者名="Sheng Mengdi"
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| 1 | Analysis of the selectivity filter of the voltage-gated sodium channel NavRh显示文摘NaChBac 是细菌的电压门钠(Na 显示出顺序类似到电压门钙隧道的 v ) 隧道。理解 Na v 隧道,我们联合了调查 Na v Rh,海洋的细菌的 NaChBac ortholog。二个 Na + 绑定地点在我们的模拟在选择过滤器(SF ) 被识别:首先,途径地点 1 由方面组成了的细胞外的 Na + 离子 Ser181 和 Glu183 组织,然后自发地到达精力充沛地 2 由 Leu179 和 Thr178 的羰基氧形成了的更有利的地点。相反, Ca 2+ 离子对被 Glu183 在地点 1 点套住敏感,它然后堵住 Na + 和 Ca 2+ 的入口到 SF 的门厅。另外, Na + 以一种不均匀的方式通过选择过滤器渗入,类似于哺乳动物的 Na v orthologs。这里报导的学习在哺乳动物的 Na 2+ 上在 Na + 上提供卓见进离子选择的机制 > v 隧道。 | Xu Zhang Mengdie Xia Yang Li Huihui Liu Xin Jiang Wenlin Ren Jianping Wu Paul DeCaen Feng Yu Sheng Huang Jianhua He David E Clapham Nieng Yan Haipeng Gong | 2013 | Cell Research2013，23，3： | 1 |
| 2 | Integrative analysis of in vivo recording with single-cell RNA-seq data reveals molecular properties of light-sensitive neurons in mouse V1显示文摘Vision formation is classically based on projections from retinal ganglion cells(RGC)to the lateral geniculate nucleus(LGN)and the primary visual cortex(V1).Neurons in the mouse V1 are tuned to light stimuli.Although the cellular information of the retina and the LGN has been widely studied,the transcriptome profiles of single light-stimulated neuron in V1 remain unknown.In our study,in vivo calcium imaging and whole-cell electrophysiological patch-clamp recording were utilized to identify 53 individual cells from layer 2/3 of V1 as lightsensitive(LS)or non-light-sensitive(NS)by single-cell light-evoked calcium evaluation and action potential spiking.The contents of each cell after functional tests were aspirated in vivo through a patch-clamp pipette for mRNA sequencing.Moreover,the three-dimensional(3-D)morphological characterizations of the neurons were reconstructed in a live mouse after the whole-cell recordings.Our sequencing results indicated that V1 neurons with a high expression of genes related to transmission regulation,such as Rtn4r and Rgs7,and genes involved in membrane transport,such as Na+/K+ATPase and NMDA-type glutamatergic receptors,preferentially responded to light stimulation.Furthermore,an antagonist that blocks Rtn4r signals could inactivate the neuronal responses to light stimulation in live mice.In conclusion,our findings of the vivo-seq analysis indicate the key role of the strength of synaptic transmission possesses neurons in V1 of light sensory. | Jianwei Liu Mengdi Wang Le Sun Na Clara Pan Changjiang Zhang Junjing Zhang Zhentao Zuo Sheng He Qian Wu Xiaoqun Wang | 2020 | Protein & Cell2020，11，6： | 0 |
| 3 | Patent Applications of Pharmaceutical Industry in Liaoning: Current Situation and Suggestions显示文摘Objective To analyze the current situation of pharmaceutical patents in Liaoning Province with the background of increasing emphasis on intellectual property rights in the pharmaceutical industry and the application of pharmaceutical-related patents having taken shape in Liaoning Province.Methods The invention patent information applied by Liaoning pharmaceutical manufacturers before December 31,2018 was obtained from Qixinbao APP,and then the retrieval data was also obtained through detailed search on patent information inquiry websites in China and other countries.The types of drug patents were separately extracted by Excel.Data analysis was carried out according to drug category,applicant type,legal status and transfer situation.Results and Conclusion A thorough discussion on the current situation of patent applications in pharmaceutical industry of Liaoning Province reveals that the number of patent applications is large but they are lack of creativity.Meanwhile,few patent applications are made by individual.Besides,there are fewer international patent applications for pharmaceutical patents in Liaoning Province.The problems in patent applications include the followings,such as insufficient patent applications and unbalanced proportion of patent applications.In order to promote the stable development of pharmaceutical market in Liaoning Province,some suggestions are raised. | Zhao Zhe Sheng Mengdi Fan Junyan Liu Yanwen Dong Li | 2019 | Asian Journal of Social Pharmacy2019，14，4： | 0 |
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