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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | 具有低动脉粥样硬化风险特征的专业耐力运动员的亚临床冠状动脉疾病发病率显示文摘研究表明,具有冠状动脉疾病(coronary artery disease,CAD)危险因素的中老年(健将)运动员比久坐个体冠状动脉钙化(coronary artery calcium,CAC)评分更高。尚没有研究评估具有低动脉粥样硬化风险特征的专业运动员的CAD患病率。 | 刘莉 叶鹏 Merghani A Maestrini V Rosmini S Cox AT Dhutia H Bastiaenen R David S Yeo TJ Narain R Malhotra A Papadakis M Wilson MG Tome M AlFakih K Moon JC Sharma S | 2017 | 中华高血压杂志2017，25，6： | 8 |
| 3 | Approaches for Optimal Planning of Energy Storage Units in Distribution Network and Their Impacts on System Resiliency显示文摘In the recent decade,a significant increase in the penetration level of renewable energy sources(RESs)into the distribution grid is evident due to the world’s shift towards clean energy and to increase the reliability or inboard manner resiliency of electrical distribution system.RES based microgrids are the most favorable option available,especially to enhance resiliency.However,the integration of RES over the distribution grid would hamper the grid stability due to its stochastic nature under normal conditions.During extreme weather conditions,RES behavior is completely uncertain.Hence there is a need to eliminate the adverse effects caused by the RES and make the distribution grid more reliable and stable under normal and resilient conditions.To address these issues,many researchers proposed several methods to place energy storage units(ESUs)and microgrids(RES integrated),which can support critical loads at an optimal location in the distribution system during normal and extreme conditions,respectively.The aim of this article is to consolidate and review the research towards various approaches to formulate the problem(optimal location,allocation,and operation of ESU and microgrids to face regular and extreme weather condition)and tools to solve it for enhanced system flexibility and resiliency.Based on the review,a generalized methodology has been designed to adapt the inputs and address both conditions.At the end of the review,future aspects for ESU to strengthen resistance and resiliency of its own are presented,which can be helpful to further improve the reliability and resiliency of the distribution system. | Balaji Venkateswaran V Devender K.Saini Madhu Sharma | 2020 | CSEE Journal of Power and Energy Systems2020，6，4： | 4 |
| 4 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 5 | Th17 cells, pathogenic or not? TGF-β3 imposes the embargo显示文摘 | Meenu Sharma | 2013 | Cellular & Molecular Immunology2013，10，2： | 2 |
| 6 | A review on ethnobotany,phytochemistry and pharmacology of Fumaria indica(Fumitory)显示文摘Fumaria indica(Hausskn.) Pugsley(Fumariaceae),known as 'Fumitory',is an annual herb found as a common weed all over the plains of India and Pakistan.The whole plant is widely used in traditional and folkloric systems of medicine.In traditional systems of medicine,the plant is reputed for its anthelmintic,diuretic,diaphoretic,laxative,cholagoguc,stomachic and sedative activities and is used to purify blood and in liver obstruction in ethnopharmacology. The whole plant is ascribed to possess medicinal virtues in Ayurvedic and Unani systems of medicine and is also used in preparation of important Ayurvedic medicinal preparations and polyhedral liver formulations.The review reveals that phytochemical constituents of wide range have been separated from the plants and it possesses important pharmacological activities like smooth muscle relaxant,spasmogenic and spasmolytic,analgesic,anti-inflammatory, neuropharmacological and antibacterial activities.The separation of hepatoprotective and antifungal constituents from this plant was also reported newly.This review highlights the traditional,ethnobotanical,phytochemical,pharmacological information available on Fumaria indica,which might be helpful for scientists and researchers to find out new chemical entities responsible for its claimed traditional uses. | Prakash Chandra Gupta Nisha Sharma Ch V Rao | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，8： | 2 |
| 7 | Plasma leptin is partly cleared by the kidney and is elevated in hemodialysis patients显示文摘 | Sharma K Robert V Beckie M | 1997 | Kidney Inter1997，51，： | 2 |
| 8 | mpaired regulatory T cell function in autoimmune Jiseases: are microRNAs the culprits?显示文摘 | Varun K Sharma Srini V Kaveri Jagadeesh Bayry | 2016 | Cellular & Molecular Immunology2016，13，2： | 2 |
| 9 | Angiotensin II receptor blockade:a novel strategy to prevent immunosup - pressant-associated cancer progression 显示文摘 | Maluccio M Sharma V Lagman M | 2001 | Transplant Proc2001，33，： | 1 |
| 10 | Mining literature for a comprehensive pathway analysis : a case study for retrieval of homocysteine related genes for genetic and epigenetic studies显示文摘 | Sharma P Senthilkumar RD Brahmaehari V | 2006 | Lipids Health Dis2006，5，： | 1 |
| 11 | In-gel detection of urease activity by nitroprusside-thiol reaction 显示文摘 | SHARMA V CHAUDARY R KHURANA J M | 2008 | Phytochem Anal2008，19，2： | 1 |
| 12 | Graft copolymerization of acrylonitrilc onto Cassia tora gum with eerie ammonium nitrate - nitricaeid as a redox initiator显示文摘 | Sharma B R Kumar V Soni P L | 2003 | Journal of Applied Polymer Science2003，，1： | 1 |
| 13 | Low high density lipo- protein cholesterol: current status and future strategies for management 显示文摘 | Singh V Sharma R Kumar A | 2010 | Vasc Health Risk Manag2010，6，2： | 1 |
| 14 | TB drug discovery:addressing issue of persistence and resistance显示文摘 | Smith C V Sharma V Saechettini J C | 2004 | Tuberculosis2004，84，2： | 1 |
| 15 | Visual interpretation of hand gestures for human-computer interaction: a review显示文摘 | Pavlovic V I Sharma R Huang H S | 1997 | IEEE Transactions on Pattern Analysis and Machine Learning1997，19，7： | 1 |
| 16 | Structure of isocitrate lyase, a persistence factor of Mycobacterium tubercu losis显示文摘 | Sharma V Sharma S Hoener zu Bentrup N | 2000 | Nat Struct Biol2000，7，8： | 1 |
| 17 | Electricity consumption- growth nexus:The case of Malaysia显示文摘 | CHANDRAN V G R SHARMA S | 2010 | Energy Policy2010，38，1： | 1 |
| 18 | Comparison of Methods of Eye Protection under General Anaesthesia显示文摘 | i Grover V K Kumar K V Sharma S | 1998 | Can J Anesth1998，45，6： | 1 |
| 19 | Optimal energy management policies for energy harvesting sensor nodes显示文摘 | Sharma V Mukherji U Joseph V | 2010 | Wireless Communica- tions IEEE Transactions2010，9，4： | 1 |
| 20 | Grinding characteristics and batter quality of rice in different wet grinding systems显示文摘 | Sharma P Chakkaravarthi A Singh V et a/ | 2008 | Journal of Food Engineering2008，88，4： | 1 |
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