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| 1 | Severe irinotecan-induced toxicity in a patient with UGT1A1*28 and UGT1A1*6 polymorphisms显示文摘Many studies have demonstrated the impact of UGT1A1 on toxicity of irinotecan. In particular, patients bear-ing UGT1A1*28 (TA 7/7) have a higher risk of severe neutropenia and diarrhea. Based on this, prescribers of irinotecan are advised that patients with UGT1A1*28 (TA 7/7) should start with a reduced dose of irinotecan, although a particular dose is not specified. Research in Asian countries has shown a lower incidence of UG-T1A1*28 (TA 7/7), while UGT1A1*6 (A/A) is more often found and is associated with severe irinotecan-related neutropenia. We report here a case of a metastatic colorectal cancer patient who is heterozygous for the UGT1A1*28 polymorphism (TA 6/7) as well as the UG-T1A1*6 polymorphism (G/A). The patient was treated with FOLFIRI for 9 cycles and underwent two irinote-can dose reductions according to pharmacokinetic data regarding exposure to the active metabolite, SN-38. Simultaneous heterozygous UGT1A1*28 and UGT1A1*6 polymorphisms may produce higher exposure to SN-38 and a higher risk of adverse effects related to irinote-can. Additional studies will be necessary to determine the optimal starting dose of irinotecan for patients with both UGT1A1*28 and UGT1A1*6 polymorphisms. | Jian-Ming Xu Yan Wang Fei-Jiao Ge Li Lin Ze-Yuan Liu Manish R Sharma | 2013 | World Journal of Gastroenterology2013，19，24： | 14 |
| 2 | Preoperative therapy in locally advanced esophageal cancer显示文摘Esophageal cancer is an aggressive malignancy associated with dismal treatment outcomes. Presence of two distinct histopathological types distinguishes it from other gastrointestinal tract malignancies. Surgery is the cornerstone of treatment in locally advanced esophageal cancer(T2 or greater or node positive); however, a high rate of disease recurrence(systemic and loco-regional) and poor survival justifies a continued search for optimal therapy. Various combinations of multimodality treatment(preoperative/perioperative, or postoperative; radiotherapy, chemotherapy, or chemoradiotherapy) are being explored to lower disease recurrence and improve survival. Preoperative therapy followed by surgery is presently considered the standard of care in resectable locally advanced esophageal cancer as postoperative treatment may not be feasible for all the patients due to the morbidity of esophagectomy and prolonged recovery time limiting the tolerance of patient. There are wide variations in the preoperative therapy practiced across the centres depending upon the institutional practices, availability of facilities and personal experiences. There is paucity of literature to standardize the preoperative therapy. Broadly, chemoradiotherapy is the preferred neo-adjuvant modality in western countries whereas chemotherapy alone is considered optimal in the far East. The present review highlights the significant studies to assist in opting for the best evidence based preoperative therapy(radiotherapy, chemotherapy or chemoradiotherapy) for locally advanced esophageal cancer. | Pankaj Kumar Garg Jyoti Sharma Ashish Jakhetiya Aakanksha Goel Manish Kumar Gaur | 2016 | World Journal of Gastroenterology2016，22，39： | 13 |
| 3 | Experimental assessment and prediction of temporal scour depth around a spur dike显示文摘Spur dikes are river training structures that have been extensively used worldwide for towards enhancing flood control and the stability of embankments and riverbanks.However,scour around spur dikes can be a major problem affecting their stability and hydraulic performance.The precise computation of temporal scour depth at spur dikes is very important for the design of economical and safe spur dikes.This study focuses on experimentally assessing the temporal variation of scour depth around a vertical wall spur dike and identifying the parameters,which mostly influence spur dike performance for a channel bed surface comprised of sand-gravel mixtures.In the current study,the authors did physical experiments in a flume based study to obtain new data,aimed at deriving a new predictive model for spur dike scour and comparing its performance to others found in the literature.It was found that the dimensionless temporal scour depth variation increases with an increase in(i)the threshold velocity ratio,(ii)the densimetric Froude number of the bed surface sediment mixture,(iii)the flow shallowness(defined as the ratio of the approach flow depth,y,to the spur dike’s transverse length,l),and(iv)the flow depth-particle size ratio.It is also concluded that the temporal scour depth variation in the sediment mixture is influenced by the non-uniformity of sediment and decreases with an increase in the non-uniformity of the sediment mixture.A new mathematical model is derived for the estimation of temporal scour depths in sand-gravel sediment mixtures.The proposed equation has been calibrated and validated with the experimental data,demonstrating a good predictive capacity for the estimation of temporal scour depth evolution. | Manish Pandey Manousos Valyrakis Meilan Qi Anurag Sharma Ajay Singh Lodhi | 2021 | International Journal of Sediment Research2021，36，1： | 8 |
| 4 | Anti-HBc screening in Indian blood donors:Still an unresolved issue显示文摘AIM:To study the seroprevalence of antibody to hepatitis B core antigen (anti-HBc) in healthy blood donors negative for HBsAg and to evaluate whether anti-HBc detection could be adopted in India as a screening assay for HBV in addition to HBsAg. METHODS: A total of 1700 serum samples collected from HBsAg-negative healthy blood donors were tested for the presence of anti-HBc antibody (IgM + IgG). All samples reactive for anti-HBc antibody were then investigated for presence of anti-HBs and for liver function tests (LFTs). One hundred serum samples reactive for anti-HBc were tested for HBV DNA by PCR method. RESULTS: Out of 1700 samples tested, 142 (8.4%) blood samples were found to be reactive for anti-HBc. It was signif icantly lower in voluntary (6.9%) as compared to replacement donors (10.4%, P = 0.011). Seventy- two (50.7%) anti-HBc reactive samples were also reactive for anti-HBs with levels > 10 mIU/mL and 70 (49.3%) samples were non-reactive for anti-HBs, these units were labeled as anti-HBc-only. These 142 anti-HBc reactive units were also tested for liver function test. HBV DNA was detected in only 1 of 100 samples tested. CONCLUSION: Keeping in view that 8%-18% of donor population in India is anti-HBc reactive, inclusion of anti- HBc testing will lead to high discard rate. Anti-HBs as proposed previously does not seem to predict clearance of the virus. Cost effectiveness of introducing universalanti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed. | Hari Krishan Dhawan Neelam Marwaha Ratti Ram Sharma Yogesh Chawla Beenu Thakral Karan Saluja Sanjeev Kumar Sharma Manish K Thakur Ashish Jain | 2008 | World Journal of Gastroenterology2008，14，34： | 8 |
| 5 | Review on current concepts of myopia and its control strategies显示文摘Myopia poses a significant burden on the healthcare system,economy and quality of life.It is an emerging global public health challenge and requires interventions to delay or stop onset and progression.With changing times and evidence,the concepts of myopia are changing along with the treatment and control strategies.Behavioural modifications including increased outdoors time and reduced near work,optical and pharmaceutical management options are reviewed.This paper presents a current overview on the concepts of myopia,and is expected to summarize updates on myopia control methods. | Raju Kaiti Ranjila Shyangbo Indra Prasad Sharma Manish Dahal | 2021 | International Journal of Ophthalmology(English edition)2021，14，4： | 3 |
| 6 | Arbutin effectively ameliorates the symptoms of Parkinson’s disease:the role of adenosine receptors and cyclic adenosine monophosphate显示文摘An antagonistic communication exists between adenosinergic and dopaminergic signaling in the basal ganglia,which suggests that the suppression of adenosine A2A receptors-cyclic adenosine monophosphate pathway may be able to restore the disrupted dopamine transmission that results in motor symptoms in Parkinson’s disease(PD).Arbutin is a natural glycoside that possesses antioxidant,antiinflammatory,and neuroprotective properties.The purpose of this study was to investigate whether arbutin could ameliorate the symptoms of PD and to examine the underlying mechanism.In this study,Swiss albino mouse models of PD were established by the intraperitoneal injection of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine for 4 successive days,with the concurrent intraperitoneal administration of arbutin(50 and 100 mg/kg)for 7 days.The results showed that arbutin significantly reduced lipid peroxidation,total nitrite levels,and inflammation in the substantia nigra and striatum of PD mouse models.In addition,arbutin decreased the activity of endogenous antioxidants,reduced the levels of dopamine,3,4-dihydroxyphenylacetic acid,homovanillic acid,andγ-aminobutyric acid,and minimized neurodegeneration in the striatum.Arbutin also reduced the abnormal performance of PD mouse models in the open field test,bar test,pole test,and rotarod test.The therapeutic efficacy of arbutin was similar to that of madopar.The intraperitoneal injection of the A2AR agonist CGS21680(0.5 mg/kg)attenuated the therapeutic effects of arbutin,whereas the intraperitoneal injection of forskolin(3 mg/kg)enhanced arbutin-mediated improvements.These findings suggest that arbutin can improve the performance of PD mouse models by inhibiting the function of the A2AR and enhancing the effects of cyclic adenosine monophosphate.This study was approved by the Institutional Animal Ethics Committee(1616/PO/Re/S/12/CPCSEA)on November 17,2019(approval No.IAEC/2019/010). | Jie Zhao Manish Kumar Jeevan Sharma Zhihai Yuan | 2021 | Neural Regeneration Research2021，16，10： | 2 |
| 7 | Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial显示文摘 | Manish Kumar Lunia Barjesh Chander Sharma Praveen Sharma Sanjeev Sachdeva Siddharth Srivastava | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 2 |
| 8 | Probiotics Prevent Hepatic Encephalopathy in Patients With Cirrhosis: A Randomized Controlled Trial显示文摘 | Manish Kumar Lunia Barjesh Chander Sharma Praveen Sharma Sanjeev Sachdeva Siddharth Srivastava | 2014 | Clinical Gastroenterology and Hepatology2014，，： | 1 |
| 9 | PDE solution to UAV/UGV trajectory planning problem by spatio-temporal estimation during wildfires显示文摘Unmanned Aerial Vehicles(UAVs)and Unmanned Ground Vehicles(UGVs)have been used in research and development community due to their strong potential in high-risk missions.One of the most important civilian implementations of UAV/UGV cooperative path planning is delivering medical or emergency supplies during disasters such as wildfires,the focus of this paper.However,wildfires themselves pose risk to the UAVs/UGVs and their paths should be planned to avert the risk as well as complete the mission.In this paper,wildfire growth is simulated using a coupled Partial Differential Equation(PDE)model,widely used in literature for modeling wildfires,in a grid environment with added process and measurement noise.Using principles of Proper Orthogonal Decomposition(POD),and with an appropriate choice of decomposition modes,a low-dimensional equivalent fire growth model is obtained for the deployment of the space-time Kalman Filtering(KF)paradigm for estimation of wildfires using simulated data.The KF paradigm is then used to estimate and predict the propagation of wildfire based on local data obtained from a camera mounted on the UAV.This information is then used to obtain a safe path for the UGV that needs to travel from an initial location to the final position while the UAV’s path is planned to gather information on wildfire.Path planning of both UAV and UGV is carried out using a PDE based method that allows incorporation of threats due to wildfire and other obstacles in the form of risk function.The results from numerical simulation are presented to validate the proposed estimation and path planning methods. | Mohammadreza RADM ANESH Balaji SHARMA Manish KUMAR Donald FRENCH | 2021 | Chinese Journal of Aeronautics2021，34，5： | 1 |
| 10 | An open label randomised controlled trial of probiotics for primary prophylaxis of hepatic encephalopathy in patients with cirrhosis显示文摘 | Manish Kumar Lunia Barjesh Chander Sharma Sanjeev Sachdeva Siddharth Srivastava | 2013 | Journal of Clinical and Experimental Hepatology2013，，1： | 1 |
| 11 | Symptomatic central canal rupture heralding the presence of an asymptomatic conus dermoid显示文摘 | Manish K. Kasliwal Sumit Sinha Bhawani Shanker Sharma Ajay Garg | 2007 | Journal of Neuro - Oncology2007，，1： | 1 |
| 12 | Intr-aoperative pulse and blood pressure recordings of neurosurgeons : Apilot study of cardiovascular performance 显示文摘 | Manish Singh Sharma Amit Thapa Sharat P Chandra | 2010 | Neurosurgery2010，66，： | 1 |
| 13 | Polar magneto-optical Kerr effect instrument for 1-dimensional magnetic nanostructures显示文摘 | Sachin Pathak Manish Sharma | 2014 | Journal of Applies Physics2014，115，04： | 1 |
| 14 | Mapping of Compositional Diversity and Chronological Ages of Lunar Farside Multiring Mare Moscoviense Basin:Implications to the Middle Imbrian Mare Basalts显示文摘The Mare Moscoviense is an astonishing rare flatland multi-ring basin and one of the recognizable mare regions on the Moon's farside.The mineralogical,chronological,topographical and morphological studies of the maria surface of the Moon provide a primary understanding of the origin and evolution of the mare provinces.In this study,the Chandrayaan-1 M^(3)data have been employed to prepare optical maturity index,FeO and TiO^(2)concentration,and standard band ratio map to detect the mafic indexes like olivine and pyroxene minerals.The crater size frequency distribution method has been applied to LROC WAC data to obtain the absolute model ages of the Moscoviense basin.The four geological unit ages were observed as 3.57 Ga(U-2),3.65 Ga(U-1),3.8 Ga(U-3)and 3.92 Ga(U-4),which could have been formed between the Imbrian and Nectarian epochs.The M^(3)imaging and reflectance spectral parameters were used to reveal the minerals like pyroxene,olivine,ilmenite,plagioclase,orthopyroxene-olivine-spinel lithology,and olivine-pyroxene mixtures present in the gabbroic basalt,anorthositic and massive ilmenite rocks,and validated with the existing database.The results show that the Moscoviense basin is dominated by intermediate TiO^(2)basalts that derived from olivine-ilmenite-pyroxene cumulate depths ranging from 200 to 500 km between 3.5 Ga and 3.6 Ga. | A.Karthi S.Arivazhagan Manish Sharma | 2022 | Research in Astronomy and Astrophysics2022，22，12： | 1 |
| 15 | A randomized con- trolled clinical trial to compare the safety and efficacy of edaravone in acute ischemic stroke 显示文摘 | Sharma Pawan Sinha Manish Shukla R | 2011 | Annals of Indian Academy of Neurology2011，14，2： | 1 |
| 16 | Screening of pea germplasm for resistance to powdery mildew显示文摘 | J. C. Rana D. K. Banyal K. D. Sharma Manish K. Sharma S. K. Gupta Satish K. Yadav | 2013 | Euphytica2013，，2： | 1 |
| 17 | Preparation and characterization of binary grafted polymeric blends of polyvinyl alcohol and gelatin and evaluation of their water uptake potential显示文摘 | Bajpai A K Sharma Manish | 2005 | J Macromol Sci Pure Appl Chem2005，42，5： | 1 |
| 18 | Novel route for rapid biosynthesis of copper nanoparticles using aqueous extract of Calotropis procera L. latex and their cytotoxicity on tumor cells显示文摘 | Shrikant Harne Ashwinikumar Sharma Mayur Dhaygude Shreeram Joglekar Kisan Kodam Manish Hudlikar | 2012 | Colloids and Surfaces B: Biointerfaces2012，，： | 1 |
| 19 | Preparation and characterization of binary grafted polymeric blends of polyvinyl alcohol and gelatin and evaluation of their water uptake potential 显示文摘 | Bajpai A K Sharma Manish | 2005 | J Macromolecular SciPure Appl Chem2005，42，5： | 1 |
| 20 | Spin-Dependent Tunneling Junctions with A1N and AION Barri- ers显示文摘 | Manish Sharma Janice H Nickel Thomas C Anthony | 2000 | Appl Phys Lett2000，，77： | 1 |
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