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| 1 | 2018加拿大心境障碍与焦虑障碍治疗协作组/国际双相障碍学会指南:双相障碍的管理显示文摘加拿大心境障碍与焦虑障碍治疗协作组(Canadian Network for Mood and Anxiety Treatments,CANMAT)曾于2005年发布了第1版双相障碍管理指南,并分别于2007、2009和2013年对该指南进行了更新,其中最近的2次更新是与国际双相障碍学会(International Society for Bipolar Disorders,ISBD)合作完成。2018版CANMAT/ISBD双相障碍治疗指南(以下简称指南)反映了自2005年首版指南发表以来本领域取得的重大进展,包括疾病诊断与疾病管理的更新以及药物治疗与心理治疗的近期研究进展。这些前沿进展中综合考虑了循证证据的级别,并基于治疗疗效、临床实践经验、安全性、耐受性和药物导致的转相风险等,对一线、二线及三线治疗方案进行了简明而清晰的推荐。本指南中新增内容涵盖了双相Ⅰ型障碍(BD-Ⅰ)的躁狂发作急性期、抑郁发作急性期和双相障碍维持期的一线及二线治疗推荐等级划分。这种对治疗推荐等级的划分综合考虑了治疗方法对双相障碍不同时相的影响,将进一步帮助临床医生做出基于循证证据的治疗决策。锂盐、喹硫平、双丙戊酸盐、阿塞那平、阿立哌唑、帕利哌酮、利培酮和卡利拉嗪单药或联合使用被推荐为躁狂发作急性期的一线治疗选择。BD-Ⅰ抑郁期的一线治疗选择包括喹硫平、鲁拉西酮、锂盐、拉莫三嗪单药,鲁拉西酮联合锂盐或双丙戊酸盐或拉莫三嗪辅助治疗。尽管急性期治疗有效的药物通常应继续用于BD-Ⅰ的维持期治疗,但也存在一些特殊情况(例如抗抑郁药)。现有数据表明,锂盐、喹硫平、双丙戊酸盐、拉莫三嗪、阿塞那平和阿立哌唑单药或联合治疗应被视为维持治疗的初始或更换治疗方案时的一线选择。除了探讨BD-Ⅰ的相关问题外,本指南中还对双相Ⅱ型障碍(BD-Ⅱ)的临床管理进行了系统回顾并给予治疗推荐,同时针对特殊人群也有相关推荐,如处于各个生殖周期的女性、儿童、青少年和老年人。此外,本指南中还讨论了特定精神疾病及共病(如物质滥用、焦虑障碍和代谢性疾病)的影响。最后,本指南中概述了安全性和药物监测的相关问题。CANMAT/ISBD工作组希望本指南能够成为全球临床医生的实用工具。 | Lakshmi N Yatham Sidney H Kennedy Sagar V Parikh Ayal Sehaffer David J Bond Benicio N Frey Verinder Sharma Benjamin I Goldstein Soham Rej Serge Beaulieu Martin Alda Glenda MaeQueen Roumen V Milev Arun Ravindran Claire O'Donovan Diane Mclntosh Raymond W Lam Gustavo Vazquez Flavio Kapczinski Roger S Melntyre Jan Kozicky Shigenobu Kanba Beny Lafer Trisha Suppes Joseph R Calabrese Eduard Vieta Gin Malhi Robert M Post Michael Berk 胡晨(译) 王刚(译) | 2019 | 中华精神科杂志2019，52，1： | 25 |
| 2 | Durability of Radiofrequency Ablation in Barrett’s Esophagus With Dysplasia显示文摘 | Nicholas J. Shaheen Bergein F. Overholt Richard E. Sampliner Herbert C. Wolfsen Kenneth K. Wang David E. Fleischer Virender K. Sharma Glenn M. Eisen M. Brian Fennerty John G. Hunter Mary P. Bronner John R. Goldblum Ana E. Bennett Hiroshi Mashimo Richard I | 2011 | Gastroenterology2011，，2： | 3 |
| 3 | Transfusion-transmitted virus in association with hepatitis A-E viral infections in various forms of liver diseases in India显示文摘瞄准:描述播送输送的病毒(TTV ) 的流行与在在诺思 India.METHODS 的肝疾病的不同形式的肝炎 A-E 病毒的感染联合的感染:从一个总数的血清 137 个病人数,包括 37 有尖锐病毒的肝炎( AVH )的病人,有长期的病毒的肝炎( CVH )的 37 个病人,有肝硬变的 31 个病人和有暴发性的肝的失败( FHF )的 32 个病人,为 TTV-DNA 和肝炎 A-E 病毒的标记两个都被分析。肝炎 B (HBV ) 的存在,丙肝病毒(HCV ) 和肝炎 E 病毒(HEV ) 感染在不同的组在不同比例被检测。而且, TTV-DNA 同时在 100 健康供血者 also.RESULTS 被测试:任何一个都没病人有肝炎 A 病毒(HAV ) 和肝炎 D 病毒(HDV ) 感染。TTV-DNA 的全面流行与 FHF 与 AVH,有 CVH 的 18.9% 盒子,有肝硬化的 48.4% 盒子和 9.4% 盒子在 27.1% 情况中被检测。同时在 100 健康供血者测试的 TTV-DNA 显示出 27% 确实。在与另外的肝炎建立在 TTV 感染之间的一种关系上病毒的感染, TTV 在这些疾病组与 HBV, HCV 和 HEV 表明了合作感染。有中高音的 TTV 的关联在重量的单位铺平一没在感染 TTV 的病人表明高中高音水平,建议那 TTV 不引起严重的肝 damage.CONCLUSION:TTV 感染在印度在病人和健康个人两个都是流行的。然而,它没与另外的肝炎有任何重要关联病毒的感染,它也不与肝疾病在病人生产严重的肝损坏的一条证据。 | M Irshad Y Sharma I Dhar J Singh YK Joshi | 2006 | World Journal of Gastroenterology2006，12，15： | 3 |
| 4 | Transfusion transmitted virus: A review on its molecular characteristics and role in medicine显示文摘现在的评论给输送的更新的概述播送病毒(TTV ) ,一个新奇代理人在与它的分子的特征的关系,流行病学的特征,传播的模式,组织向性,致病,在各种各样的疾病的角色和它从身体的根除。TTV,一个 DNA 病毒,一个单身者被搁浅,非包,有包括 3852 的一个小、 covalently 关上的圆形的染色体的长 DNA 病毒基于的 3.8 kb。它是尝试性地指明的 Circinoviridae 病毒。TTV 染色体顺序是异构的并且揭示六不同遗传型和几种子类型的存在。TTV 被报导了不仅经由非肠道的线路,而且经由交替的线路播送。这个病毒也在不同非人类的首领被检测了。目前, TTV 被聚合酶链反应(PCR ) 没有另外的可得到的诊断试金检测。它全球性显示出它的存在并且在健康的人的高百分比人口以及在各种各样的疾病组被检测。开始,它应当与肝疾病有强壮的协会;然而,几乎没有小证据在引起肝疾病显示出它的肝向性和贡献。它在牙齿过敏细胞溶解病人显示出高流行,向它在肾的疾病的意义指。另外, TTV 与几传染、非传染的疾病被联系。不过,它的准确致病是还没清楚的, TTV 病毒可能住并且在骨髓房间和外部血乘单音的原子房间(PBMC ) 。最近,被尝试了根除有干扰素治疗的这个病毒。更多的信息仍然被需要解脱与 TTV 有关的各种各样的谜。 | M Irshad YK Joshi Y Sharma I Dhar | 2006 | World Journal of Gastroenterology2006，12，32： | 3 |
| 5 | Ciliated hepatic foregut cyst:an increasingly diagnosed condition显示文摘BACKGROUND:Ciliated foregut cysts of the liver are rare, with only 96 cases diagnosed since the first description in 1857.They are being increasingly diagnosed recently;the majority of the cases have been reported in the last 15 years. Although they bear a close resemblance to the simple cyst of the liver which has essentially a benign course,ciliated hepatic foregut cysts(CHFCs)can progress to malignancy with devastating consequences.It is imperative that this group of conditions be diagnosed and treated adequately. DATA SOURCES:This review includes discussion of the data from all the 96 reported cases from English and non-English literature.Analysis of the incidence rates, embryogenesis,growth,clinical features,risk of malignancy and the prognosis are highlighted systematically.The roles of various diagnostic modalities including ultrasound, CT,MRI,fine needle aspiration cytology(FNAC), immunohistochemistry and surgery are further discussed. RESULTS:The mean age of patients with CHFC was 48± 12 years.The male/female ratio was 1.1∶1.The majority of patients with CHFC(62%)were asymptomatic,and the common mode of presentation was right upper abdominal pain.The cysts occurred in the left lobe in 51 patients, with sole location in segmentⅣin 44,and in the right lobe in 26.The average size of the cysts was 3.6±2.12 cm. The majority of the cysts were unilocular,and only 7 cases were multilocular.Cyst contents were described as viscous or mucinous in 73 patients,whereas bilious fluid was noted in 3.Large cysts having squamous carcinoma were cited in 3 patients,and 2 had extensive squamous metaplasia without malignancy.Others had benign histopathology. CONCLUSIONS:Clinicians have become increasingly aware of CHFC.Imaging alone is not diagnostic per se, but when considered in the context of the global picture does provide important clues to the diagnosis.FNAC is diagnostic by the presence of the ciliated columnar aspirate but lacks sensitivity.Infantile presentation is usually accompanied by biliary communication and mandates a different surgical approach.The demonstration of malignant transformation in 3 cases and its fatal course emphasizes the need for surgical resection in all cases once the diagnosis is made. | Sharad Sharma Amanda G.Dean Ayumi Corn Vivek Kohli Harlan I Wright Anthony Sebastian Nicolas Jabbour | 2008 | Hepatobiliary & Pancreatic Diseases International2008，7，6： | 2 |
| 6 | Plant growth hormone kinetin delays ageing,prolongs the lifespan,and slows down development of the fruitfly zaprionus paravittegei显示文摘 | Sharma S P Kaur J Rattan S I | 1995 | Biochem Biophys Res Commun1995，216，3： | 1 |
| 7 | Visual interpretation of hand gestures for human-computer interaction: a review显示文摘 | Pavlovic V I Sharma R Huang H S | 1997 | IEEE Transactions on Pattern Analysis and Machine Learning1997，19，7： | 1 |
| 8 | Comparison of Methods of Eye Protection under General Anaesthesia显示文摘 | i Grover V K Kumar K V Sharma S | 1998 | Can J Anesth1998，45，6： | 1 |
| 9 | Visual Interpretation ofHand Gestures for Human-computer Interaction:A Review显示文摘 | Pavlovic V I Sharma R Huang T S | 1997 | IEEE Transactions on Pattern Analysis and MachineIntelligence1997，19，7： | 1 |
| 10 | Tendon injury and tendinopathy:healing and repair显示文摘 | Sharma P Mafful i N | | 0，，01： | 1 |
| 11 | Shear strength of geomembrane-soil interface under unsaturated conditions显示文摘 | Sharma J S Jogi M B | 2006 | Geotextiles and Geomembranes2006，24，： | 1 |
| 12 | Production of Al-Zr master alloy starting from ZrO2 显示文摘 | RAJAGOPALAN p K SHARMA I G KRISHNAN T S | 1999 | Journal of Alloys and Compounds1999，285，3： | 1 |
| 13 | RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer显示文摘 | BEPLER G KUSMARTSEVA I SHARMA S | 2006 | J C/in Oncol2006，24，29： | 1 |
| 14 | RRM1 modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer显示文摘 | Bepler G Kusmanseva I Sharma S | | 0，，29： | 1 |
| 15 | Gold Nanoparticles Induce Transcriptional Activity of NF-Kappa B in a B-Lymphocyte Cell Line显示文摘 | Sharma M Salisbury R L Maurer E I | 2013 | Narwscale2013，5，9： | 1 |
| 16 | Pregabalin relieves symptoms of painful diabetic neuropathy:a randomized controlled trial显示文摘 | Lesser H Sharma U Lamoreaux I | | 0，，11： | 1 |
| 17 | Effects of Momordica charantia fruit juice on islet morphology in the pancreas of the streptozotocin-diabetic rat 显示文摘 | Ahmed I Adeghate E Sharma A K | 1998 | Diabetes Research and Clinical Practice1998，40，3： | 1 |
| 18 | Present-day locoregional control in patients with tl or t2 breast cancer with 0 and 1 to 3 posi- tive lymph nodes after mastectomy without radiotherapy显示文摘 | Sharma R Bedrosian I Lucci A | 2010 | Ann Surg Oncol2010，17，11： | 1 |
| 19 | Synthetic and novel biocatalytic resolution studies on( ± )- 5/6/7-acetoxy-4-aryl-3,4-dihydrocoumarins 显示文摘 | SINGH I PRASAD A K SHARMA A K | 2003 | Bioorg Med Chem2003，11，4： | 1 |
| 20 | RRMI modulated in vitro and in vivo efficacy of gemcitabine and platinum in non-small-cell lung cancer显示文摘 | Bepler G Kusmartseva I Sharma S | 2006 | J Clin Oncol2006，24，29： | 1 |
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