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| 1 | Impact of diabetes mellitus on risk of cardiovascular disease and all-cause mortality: Evidence on health outcomes and antidiabetic treatment in United States adults显示文摘AIMTo examine the epidemic of diabetes mellitus (DM) and its impact on mortality from all-cause and cardiovascular disease (CVD), and to test the effect of antidiabetic therapy on the mortality in United States adults. METHODS The analysis included a randomized population sample of 272149 subjects ages ≥ 18 years who participated in the National Health Interview Surveys (NHIS) in2000-2009. Chronic conditions (hypertension, DM and CVD) were classified by participants’ self-reports of physician diagnosis. NHIS-Mortality Linked Files, and NHIS-Medical Expenditure Panel Survey Linkage Fileson prescribed medicines for patients with DM were used to test the research questions. χ 2, Poisson and Cox’s regression models were applied in data analysis.RESULTS Of all participants, 22305 (8.2%) had DM. The prevalence of DM significantly increased from 2000 to 2009 in all age groups (P < 0.001). Within an average 7.39 (SD= 3) years of follow-up, male DM patients had 1.56 times higher risk of death from all-cause (HR = 1.56, 95%CI:1.49-1.64), 1.72 times higher from heart disease [1.72 (1.53-1.93)], 1.48 times higher from cerebrovascular disease [1.48 (1.18-1.85)], and 1.67 times higher from CVD [1.67 (1.51-1.86)] than subjects without DM,respectively. Similar results were observed in females. In males, 10% of DM patients did not use any antidiabetic medications, 38.1% used antidiabetic monotherapy, and 51.9% used ≥ 2 antidiabetic medications. These corresponding values were 10.3%, 40.4% and 49.4% in females. A significant protective effect of metformin monotherapy or combination therapy (except for insulin) on all-cause mortality and a protective but non-significant effect on CVD mortality were observed. CONCLUSION This is the first study using data from multiple linkage files to confirm a significant increased prevalence of DM in the last decade in the United States. Patients with DM have significantly higher risk of death from all-cause and CVD than those without DM. Antidiabetic mediations,specifically for metformin use, show a protective effect against all-cause and CVD mortalities. | Longjian Liu Barbara Simon Jinggaofu Shi Arshpreet Kaur Mallhi Howard J Eisen | 2016 | World Journal of Diabetes2016，7，18： | 12 |
| 2 | Identification and isolation of candidate human keratinocyte stem cells based on cell surface phenotype显示文摘 | Li A Simmons P J Kaur P | 1998 | Proc Natl Acad Sci U S A1998，95，7： | 2 |
| 3 | Enrichment for murine keratinocyte stem cells based on cell surface phenotype显示文摘 | Tani H Morris R J Kaur P | 2000 | Proc Natl Acad Sci U S A2000，97，10： | 2 |
| 4 | Arsenic exposure and cardiovascular disorders : an overview 显示文摘 | Balakumar P Kaur J | 2009 | Cardiovasc Toxicol2009，9，4： | 1 |
| 5 | Reflection and refraction of SH-waves at a corrugated interface between two laterally and vertically heterogeneous viscoelastic solid half-spaces显示文摘 | Kaur J Tomar S K Kaushik V P | 2005 | International Journal of Solids and Structures2005，42，： | 1 |
| 6 | Plant growth hormone kinetin delays ageing,prolongs the lifespan,and slows down development of the fruitfly zaprionus paravittegei显示文摘 | Sharma S P Kaur J Rattan S I | 1995 | Biochem Biophys Res Commun1995，216，3： | 1 |
| 7 | 显示文摘 | Singh R Kumar J Kaur A | 2006 | Polymer2006，47，： | 1 |
| 8 | Factors influencing the physico-chemical, morphological, thermal and rheological properties of some chemically modified starches for food applications-a review 显示文摘 | Jaspreet Singh Lovedeep Kaur McCarthy O J | 2007 | Food Hydrocolloids2007，21，： | 1 |
| 9 | Palonosetron : A novel approach to control postoperative nausea and vomiting in day care surgery显示文摘 | Bajwa SS Bajwa SK Kaur J | 2011 | Saudi J Anaesth2011，5，1： | 1 |
| 10 | Effects of the Mi 1, N and tabasco genes on infection and reproduction of Meloidogyne mayaguensis on tomato and pepper genotypes 显示文摘 | Brito J A Stanley J D Kaur R | 2007 | Journal of Nematology2007，39，4： | 1 |
| 11 | G9a histone methyltransferase inhibitor BIX01294 promotes expansion of adult cardiac progenitor cells without changing their phenotype or differentiation potential Authors显示文摘 | K Kaur J Yang JG Edwards | 2016 | Cell Proliferation2016，49，： | 1 |
| 12 | Effect of Glycerol Monostearate on the Physico-chemical, Thermal, Rheological and Noodle Making Properties of Corn and Potato Starches显示文摘 | Kaur L Singh J Singh N | 2005 | Food Hydrocolloids2005，19，： | 1 |
| 13 | Transcriptional regulation of polysialylated neural cell adhesion molecule expression by NMDA receptor activation in retinoic acid-differentiated SH-SY5Y neuroblastoma cultures 显示文摘 | Singh J Kaur G | 2007 | Brain Res2007，1154，： | 1 |
| 14 | Identification of chemerin receptor (ChemR23) in human endothelial cells: Chemerin- induced endothelial angiogenesis显示文摘 | Kaur J Adya R Tan BK | 2010 | Biochem Biophys Res Commun2010，391，4： | 1 |
| 15 | Peroxisome proliferator activator receptor-r agonist and 15-deoxy-12, 14-PGJ2 induce apoptosis in normal and malignant B-lineage cells显示文摘 | Padilla J Kaur K Cao HJ | 2000 | Immunol2000，165，： | 1 |
| 16 | Fine particulate matter and carbon monoxide exposure concentrations in urban street transport microenvironment显示文摘 | KAUR S NIEUWENHUIJSENB M J COLVILE R N | | 0，，23： | 1 |
| 17 | Inherited metabolic disorders involving the eye:a clinico-biochemical perspective显示文摘 | Rajappa M Goyal A Kaur J | | 0，，： | 1 |
| 18 | Dexmedetomidine and elonidine in epidural anaesthesia:A comparative evalua- tion显示文摘 | Bajwa SJ Bajwa SK Kaur J | 2011 | Indian J Anaesth2011，55，2： | 1 |
| 19 | Stromelysin 3, Ets-1, and vascular endothelial growth factor expression in oral precancerous and cancerous lesions: correlation with microvessel density, progression, and prognosis显示文摘 | Arora S Kaur J Sharma C | 2005 | Clin Cancer Res2005，11，6： | 1 |
| 20 | Studies on the sorption behaviour of some amino acids on silica gel pretreated with alkalies in relation to chromatography显示文摘 | Kaur P Mundhara G L Tiwari J S | 1991 | Adsorption Science and Technology1991，8，3： | 1 |
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