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| 1 | Evaluation of anti-apoptotic activity of different dietary antioxidants in renal cell carcinoma against hydrogen peroxide显示文摘Objective:To evaluate the anti-apoptotic and radical scavenging activities of dietary phenolics, namely ascorbic acid,a-tocopherol acetate,citric acid,salicylic acid,and estimate H_2O_2induced apoptosis in renal cell carcinoma cells.Methods:The intracellular antioxidant potency of antioxidants was investigated.H_2O-2-induced apoptosis in RCC-26 was assayed with the following parameters:cell viability(%apoptosis),nucleosomal damage and DNA fragmentation, bcl-2 levels and flow cytometery analysis(ROS production evaluation).Results:Ine anticancer properties of antioxidants such as ascorbic acid,a- tocopherol acetate,citric acid,salicylic acid with perdurable responses were investigated.It was observed that these antioxidants had protective effect(anti-apoptotic activity) against hydrogen peroxide(H_2O_2) in renal cell carcinoma(RCC-26) cell line.Conclusions:This study reveals and proves the anticancer properties.However,in cancer cell lines anti-apoptotic activity can indirectly reflect the cancer promoter activity through radicals scavenging,and significantly protect nucleus and bcl-2. | Garg Neeraj K Mangal Sharad Sahu Tejram Mehta Abhinav Vyas Suresh P Tyagi Rajeev K | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，1： | 4 |
| 2 | High efficiency creation of human monoclonal antibody-producing hybridomas显示文摘 | Scott KD Sharad P Adekar JB | 2004 | J Immunoll Meths2004，291，： | 1 |
| 3 | Liquisolid corn- pact: a new technique for enhaneement of drug dissolution 显示文摘 | Sahil M G Sharad S P Shirish V S | 2011 | Int JRes Pharm Chem2011，1，3： | 1 |
| 4 | Synthesis and Characterization o{ Polyamides Con- taining Pendant Pentadecyl Chains显示文摘 | Arvind S More Sharad K Pasale Prakash P Wadga- onkar | 2010 | European Polymer Journal2010，46，： | 1 |
| 5 | Organocatalytie enantioseleetive synthesis of 13- blockers:(S)-pmpranolol and(S)-naftopidil显示文摘 | Sharad P Panchgalle Rohitkumar G Gore Subhash P Chavan | | 0，，： | 1 |
| 6 | Survival of Escherichia coli O157: H7 in Soil and on Carrots and Onions Grown in Fields Treated With Contaminated Manure Composts or Irrigation Water显示文摘 | MAHBUB I MICHAEL P D SHARAD C P | 2005 | Food Microbiology2005，22，1： | 1 |
| 7 | Analysis of soil water retention data using artificial neural networks显示文摘 | Sharad K Jain Vijay P Singh | 2004 | Journal of Hydrologic Engineering2004，9，： | 1 |
| 8 | Effect of newly synthesized 1,2,4-triazino[5,6-b]indole-3-thione derivatives on olfactory bulbectomy induced depression in rats显示文摘Objective:To study the derivatives of 1,2,4-triazino[5,6-b]indole-3-thione for antidepressant activity in olfactory bulbectomized(OBX)rats.Out of various derivatives tested for acute tail suspension test,the two derivatives showiug prominent action were.selected for bilateral olfactory bulbeetomy rsodel of ehronic depression in rats.Methods:The sub aeute effects of 14-day oral pretreatment of two derivatives labeled as 3a(70 mg/kg)and 3r(70 mg/kg),imipramine(20 mg/kg),fluoxetiue(30 mg/kg)and moclobemide(15 mg/kg)were evaluated on bilateral bulbectomy induced rise in body weight,hyperphagia,hyperactivity,and on sexual dysfunction.The serum sodium concentration,body temperature,and heart rate were also recorded.Results:The derivatives3a and 3r showed reversal of drop in body weight,reversed OBX indueed hyperactivity,normalized body temperature,heart rate,and serum sodium concentration.In elevated maze test,moclobemide,3a,3r treatment significantly redueed time spent in open arm as compared to OBX rats.3a and 3r also irsproved sexual behavior parameters.Conclusions:The present study shows promising antidepressant action and provides a proof of concept for the chronic treatrsent of 3a,3r to treat depression. | Urmila M Aswar Padmaja P Kalshetti Suhas M Shelke Sharad H Bhosale Subhash L Bodhankar | 2012 | Asian Pacific Journal of Tropical Biomedicine2012，2，12： | 1 |
| 9 | Prolonged Neonatal Jaundice and the Diagnosis of Biliary Atresia:A Single-Center Analysis of Trends in Age at Diagnosis and Outcomes显示文摘 | Sharad I Wadhwani BA Yumirle P | 2008 | Pediatrics2008，121，： | 1 |
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