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| 1 | CTGF, intestinal stellate cells and carcinoid fi brogenesis显示文摘AIM: To investigate the role of small intestinal carcinoid tumor-derived fibrotic mediators, TGFβ1 and CTGF, in the mediation of fi brosis via activation of an 'intestinal' stellate cell. METHODS: GI carcinoid tumors were collected for Q RT-PCR analysis of CTGF and TGFβ1. Markers of stellate cell desmoplasia were identified in peritoneal fibrosis by immunohistochemistry and stellate cells cultured from fresh resected fibrotic tissue. CTGF and TGFβ1 were evaluated using quantitative tissue array profi ling (AQUA analysis) in a GI carcinoid tissue microarray (TMA) with immunostaining and correlated with clinical and histologically documented fi brosis. Serum CTGF was analyzed using a sandwich ELISA assay. RESULTS: Message levels of both CTGF and TGFβ1 in SI carcinoid tumors were signifi cantly increased (> 2-fold, P < 0.05) versus normal mucosa and gastric (non-f ibrotic) carcinoids. Activated stellate cells and markers of stellate cell-mediated fi brosis (vimentin, desmin) were identifi ed in histological fibrosis. An intestinal stellate cell was immunocytochemically and biochemically characterized and its TGFβ1 (10-7M) initiated CTGF transcription response (> 3-fold, P < 0.05) demonstrated. In SI carcinoid tumor patients with documented fi brosis, TMA analysis demonstrated higher CTGF immunostaining (AQUA Score: 92 ± 8; P <0.05), as well as elevated TGFβ1 (90.6 ± 4.4, P < 0.05). Plasma CTGF (normal 12.5 ± 2.6 ng/mL) was increased in SI carcinoid tumor patients (31 ± 10 ng/mL, P < 0.05) compared to non-fi brotic GI carcinoids (< 15 ng/mL).CONCLUSION: SI carcinoid tumor fibrosis is a CTGF/ TGFβ1-mediated stellate cell-driven fibrotic response. The delineation of the biology of fibrosis will facilitate diagnosis and enable development of agents to obviate its local and systemic complications. | M Kidd IM Modlin MD Shapiro RL Camp SM Mane W Usinger JR Murren | 2007 | World Journal of Gastroenterology2007，13，39： | 5 |
| 2 | 早产儿视网膜病变早期治疗(ETROP)过程中发生视网膜脱离眼的预后显示文摘研究对象:在早产儿视网膜病变早期治疗(ETROP)研究中因早产儿视网膜病变(ROP)而发生视网膜脱离眼的结构以及功能改变。
研究方法:加入ETROP研究中的新生儿患有双眼高危阈前ROP,随即对其一眼进行早期治疗,另一眼进行传统治疗。只有单眼患病的早产儿。随机对高危阈前ROP眼进行早期治疗或传统治疗。当视网膜脱离被发现时。研究者会继续观察患者病变或对其行视网膜玻璃体手术(如巩膜加压术以肜或者玻璃体切除术)。在矫正9月龄时,对患者视网膜状况进行评估并使用条栅视敏度(grating acuity)对患儿视力进行检测。
研究结果:401例高危阈前ROP患者加入了ETROP研究。63例患者(89只眼)发生了视网膜脱离。对其中56例患者(78只眼)进行了随访。21例患者(38%)的视网膜脱离发生于双眼。其中30只眼分级为4A,14只眼为4B,16只眼为5级。余下的18只视网膜脱离眼未进行分级。对11例患者(12只眼)监控病情变化,52例患者(66只眼)行玻璃体视网膜手术。行玻璃体切除伴或不伴有巩膜加压术的56只眼中有17只(30%)在患者9月龄时保持或达到了黄斑复位;仅行巩膜加压术的10只眼中,6只(60%)达到;未行手术的12只眼中,2只(17%)达到。78只眼中有13只(17%)达到了较好的视力水平(I〉1.85cycles/degree)。达到正常视力水平(≥3.70cycles/degree)的6只眼的视网膜脱离分级均为4A(其分别为6只未行手术眼中的1眼,6只行巩膜加压术眼中的3眼。18只行玻璃体切除术眼中的2眼)。对11只视网膜脱离达5级的患眼行玻璃体视网膜手术。
治疗结果为6只眼无光感,3只眼仅有光感,2只眼只能看清低视力表。结论:在ETROP的研究中,ROP导致视网膜脱离的治疗结果普遍较差。因视网膜脱离行玻璃体视网膜手术的48只眼中,有16只眼黄斑未发生脱离。手术修复4A级视网膜脱离的24只眼中,有5只(21%)在术后达到了正常视力水平。对视网膜脱离5级眼行玻璃体视网膜手术可以使其达到结构复位,但功能恢复不佳。 | Michael X. Repka Betty Tung William V. Good Michael Shapiro Antonio Capone Jr John D. Baker Charles C. Barr Dale L. Phelps W. A. J. van HewvenMD John D. Baker,MD Charles C. Barr,MD Dale L. Phelps,MD IV. A. J. van Heuven 张弛(译) | 2006 | 美国医学会眼科杂志(中文版)2006，18，3： | 4 |
| 3 | The association of sepsis syndrome and organ dysfunction with mortality in emergency department patients with suspected infection显示文摘 | Shapiro N Howell MD Bates DW | 2006 | Ann Emerg Med2006，48，5： | 1 |
| 4 | Use of plasma brain natriuretic peptide concentration to aid in the diagnosis of heart failure显示文摘 | Shapiro MD Homg H | 2003 | Mayo clinproe2003，78，6： | 1 |
| 5 | A Longitudinal perspective on differentiation of self,interpersonal and psychological well-being in young adulthood显示文摘 | Skowron EA Stanley KL Shapiro MD | 2009 | Contemp Fam Ther2009，31，： | 1 |
| 6 | Implementa?tion andoutcomes of the multiple urgent sepsis therapies (MUST) protocol显示文摘 | Shapiro NI Howell MD Talmor D | 2006 | Crit Care Med2006，34，4： | 1 |
| 7 | Implementation and outcomes of the Multiple Urgent Sepsis Therapies (MUST) protocol 显示文摘 | Shapiro NI Howell MD Talmor D | 2006 | Crit Care Med2006，34，4： | 1 |
| 8 | Serum lactate as a predictorofmortality in emergency department patients with infection显示文摘 | Shapiro NI Howell MD Talmor D | 2005 | Ann Emerg Med2005，45，5： | 1 |
| 9 | Siegfried Oberndor- fer: origins and perspectives of carcinoid tumors 显示文摘 | Modlin IM Shapiro MD Kidd M | 2004 | Hum Pathol2004，35，12： | 1 |
| 10 | Efficacy of prescan beta-blockade and impact of heart rate on image quality in patients undergoing coronary multidetector computed tomography angiography显示文摘 | SHAPIRO MD PENA AJ NICHOLS JH | 2008 | Eur J Radiol2008，66，： | 1 |
| 11 | The association of sepsis synd- rome and organ dysfunction with mortality in emergency department patients with suspected infection显示文摘 | Shapiro N Howel MD Bates DW | 2006 | Ann Emerg M2006，48，5： | 1 |
| 12 | Mortality in Emergency Department Sepsis (MEDS) score predicts 1-year mortality显示文摘 | Shapiro NI Howell MD Talmor D | | 0，，01： | 1 |
| 13 | An analysis of rare carcinoid tumors:clarifying these clinical conundrums显示文摘 | Modlin IM Shapiro MD Kidd M | 2005 | World J Surg2005，29，1： | 1 |
| 14 | A longitudinal perspective on dif- ferentiation of self,interpersonal and psychological well- being in young adulthood显示文摘 | Skowron EA Stanley KL Shapiro MD | 2009 | Contemp Fam Ther2009，31，1： | 1 |
| 15 | Primary Carcinoid Tumor of the Parotid gland:a Case Report and Review of the Literature显示文摘 | Modlin IM Shapiro MD Kidd M | 2006 | Ear Nose Throat J2006，85，8： | 1 |
| 16 | Intgrated imaging of adrenal disease显示文摘 | Francis IR Gross MD Shapiro B | 1992 | Radiology1992，184，： | 1 |
| 17 | Association between cardiovascular risk profiles and the presence and extent of different types of coronary atherosclerotic plaque as detected by multidetector computed tomography显示文摘 | Bamberg F Dannemann N Shapiro MD | 2008 | Arterioscler Thromb Vasc Biol2008，28，3： | 1 |
| 18 | A longitudinal perspective on differentiation of self, interpersonal and psychological well-being in young adulthood 显示文摘 | Skowron EA Stanley KL Shapiro MD | 2009 | Contemp Fam Ther2009，31，1： | 1 |
| 19 | Paclitaxel- induced apoptosis and mitotic arrest assessed by serial fine- needle aspiration: implications for early prediction of breast cancer response to neoadjuvant treatment 显示文摘 | Symmans WF Volm MD Shapiro RL | 2000 | Clin Cancer Res2000，6，12： | 1 |
| 20 | Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart显示文摘 | Moss JB Xavier-Neto J Shapiro MD | 1998 | Dev Biol1998，199，： | 1 |
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