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您的检索式：作者名="Shaoyan Xi"
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| 1 | CD30 expression in extranodal natural killer/T-cell lymphoma,nasal type among 622 cases of mature T-cell and natural killer-cell lymphoma at a single institution in South China显示文摘Background:Mature T-cell and natural killer(NK)-cell lymphomas compose a heterogeneous group of non-Hodgkin lymphomas,and extranodal NK/T-cell lymphoma,nasal type(ENKTL) is an aggressive subtype with sporadic CD30 expression.However,the significance of CD30 expression in ENKTL is controversial.We aimed to classify a large cohort of patients with mature T-cell and NK-cell lymphomas according to the 2016 World Health Organization(WHO) classification guidelines and to study the association between CD30 expression and prognosis of patients with ENKTL.Methods:We selected consecutive patients with mature T-cell and NK-cell lymphomas who attended our institution between September 1,2009 and August 31,2013.We classified the lymphomas according to the 2016 revision of the WHO classification of lymphoid neoplasms,analyzed the associations between CD30 expression and clinicopathologic features of ENKTL patients,and evaluated the prognostic implications of CD30 expression.Results:We identified 622 consecutive patients with mature T-cell and NK-cell lymphomas,including 317(51.0%)patients with ENKTL.In addition,CD30 expression was detected in 43(47.3%) of a subset of 91 patients with ENKTL.No clinicopathologic features were associated with CD30 expression,and CD30 positivity showed no prognostic significance in patients with ENKTL.Conclusions:ENKTL is the most common type of mature T-cell and NK-cell lymphoma diagnosed at our institution.CD30 is frequently expressed in ENKTL and represents a therapeutic target;however,it may not be a prognostic marker. | Yanfen Feng Huilan Rao Yiyan Lei Yuhua Huang Fang Wang Yu Zhang Shaoyan Xi Qiuliang Wu Jianyong Shao | 2017 | Chinese Journal of Cancer2017，36，6： | 10 |
| 2 | 中国南方单中心622例成熟T细胞和自然杀伤细胞淋巴瘤患者中CD30在结外鼻型自然杀伤/T细胞淋巴瘤组织中的表达显示文摘背景与目的成熟T细胞和自然杀伤细胞(natural killer,NK)淋巴瘤为非霍奇金淋巴瘤中的一类异质性肿瘤,其中结外鼻型NK/T细胞淋巴瘤(extranodal NK/T?cell lymphoma,nasal type,ENKTL)为一个侵袭性的亚型,伴有散发性CD30表达。但是CD30表达在ENKTL中的意义仍存有争议。本研究的目的是根据2016年世界卫生组织(World Health Organization,WHO)的分类指南,对大样本成熟T细胞和NK细胞淋巴瘤患者进行分类,并研究CD30表达与ENKTL患者预后之间的关系。方法我们选择了2009年9月1日到2013年8月31日之间,来我中心治疗的所有成熟T细胞和NK细胞淋巴瘤的患者。根据WHO 2016年淋巴瘤分类指南进行了分类,分析了CD30表达与ENKTL患者临床病理因素的相关性,并评价了CD30表达对ENKTL患者预后的影响。结果我们共鉴定了622例成熟T细胞和NK细胞淋巴瘤的患者,其中317例(51.0%)为ENKTL患者。我们在其中的91例ENKTL患者标本中检测了CD30的表达,其中43例(47.3%)表达阳性。在这91例ENKTL患者中,CD30表达与临床病理因素无相关性,CD30表达阳性对患者预后无影响。结论在本中心确诊的成熟T细胞和NK细胞淋巴瘤中,ENKTL是最常见的一个亚型。CD30在ENKTL中高频表达,可作为一个治疗靶点;然而它可能不是ENKTL的预后标志物。 | Yanfen Feng Huilan Rao Yiyan Lei Yuhua Huang Fang Wang Yu Zhang Shaoyan Xi Qiuliang Wu Jianyong Shao | 2018 | 癌症2018，37，5： | 0 |
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