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| 1 | Evolutionary analysis of allotetraploid hybrids of red crucian carp×common carp,based on ISSR,AFLP molecular markers and cloning of cyclins genes显示文摘The allotetraploid hybrids of red crucian carp × common carp are the first reported artificially cultured polyploid fish with bisexual fertility and stable inheritance in vertebrate. Using ISSR and AFLP markers and the cyclins genes, the genomes and cyclin gene sequence changes were analyzed between the allotetraploid hybrids and their parents. The results indicated that the allotetraploids inherited many genetic characteristics from their parents and the genetic characteristics were stable after 15 generations. However, the allotetraploids had a closer genetic relationship with their original female parents and represented a bias toward the maternal progenitor. DNA fingerprinting analysis showed that the allotetraploids had undergone sequences deletion from their original parents and that the deleted sequences were mostly from the male parent's genome. Some non-parental bands were found in the allotetraploid hybrids. Sequences analysis of the cyclin A1 and B1 genes showed nonsynonymous substitutions of single nucleotides in codons that were different from their original parents, leading to non-parental amino acid loci. We speculate that the non-additivity in the allotetraploids, compared with their progenitors, could be an adjustment to the genomic shock from heterozygosity and polyploidy, allowing maintenance of genetic stability. | LIU LiangGuo YAN JinPeng LIU ShaoJun LIU Dong YOU CuiPing ZHONG Huan TAO Min LIU Yun | 2009 | Chinese Science Bulletin2009，54，16： | 6 |
| 2 | Comparative analysis and evolutionary significance of the HMG1 gene in crucian carp,blunt snout bream,and their polyploid progeny显示文摘高活动性组蛋白质的全身的 mRNA 1 个编码基因(HMG1 ) 被 RACE-PCR 从红鲫鱼鲤鱼(Carassius auratus 红 var ) 获得,钝猪嘴鲷(Megalobrama amblycephala ) ,并且他们的三倍性并且 tetraploid 子孙。顺序包含了为 193 氨基酸编码的 579 核苷酸的一个开的读物框架。HMG1 的核苷酸身份比在 tetraploid 混血儿和父亲的钝猪嘴鲷(97%) 之间在 tetraploid 混血儿和母亲的红鲫鱼鲤鱼(99%) 之间是更高的。在三倍性的混血儿和每个父母(95%) 之间的核苷酸身份在父母(98%) 之间是比那低的。在 tetraploid 混血儿和每个父母(100%) 之间的蛋白质身份在三倍性的混血儿和每个父母(97%) 之间比那高。我们的结果建议种间的杂交在三倍性的混血儿产生震动到 HMG1 基因,引起核苷酸的分叉。tetraploid 混血儿的 HMG1 蛋白质与它的父母的一致,它减少了在等位基因之间的生气不兼容的障碍,提供形成在自然的新多倍体种的两性的肥沃的 tetraploid 混血儿的基础。HMG1 蛋白质的第二等、第三级的结构包含八他 lices,三个开关,在 N 终点的二个 DNA 有约束力的领域,和在 C 终点的一条长酸的尾巴。一起,这些数据建议 HMG1 蛋白质起蛋白质 DNA 相互作用的一个作用,在原子核便于各种各样的 DNA 依赖的活动。我们也调查了鱼,两栖动物,爬虫,鸟,和哺乳动物的 HMG1 蛋白质的发展史。我们的结果建议 HMG1 是高度被保存了的祖先的蛋白质。这些数据提供种间的杂交怎么可以形成多倍体混血儿的线索。 | Dong Liu Zhen Liu Shaojun Liu Liangguo Liu Cuiping You Lin Chen Huan Zhong Yun Liu | 2009 | Progress in Natural Science:Materials International2009，19，12： | 1 |
| 3 | Identification and Expression Analysis of Genes Involved in Early Ovary Development in Diploid Gynogenetic Hybrids of Red Crucian Carp × Common Carp显示文摘 | Dong Liu Shaojun Liu Cuiping You Lin Chen Zhen Liu Liangguo Liu Jing Wang Yun Liu | 2010 | Marine Biotechnology2010，，2： | 1 |
| 4 | Cloning and evolutionary analysis of cyclin B gene introns in cyprinids with different ploidy levels显示文摘Partial fragments of the cyclin B gene from triploid, tetraploid, and pentaploid hybrids of red crucian carp blunt snout bream, blunt snout bream, grass carp, silver carp, and bighead carp were amplified. One DNA fragment was amplified from the blunt snout bream, grass carp, silver carp, and bighead carp (750, 950, 720, and 720 bp, respectively). Two fragments (1200 and 900 bp) were amplified from the red crucian carp, common carp, and allotetraploids. The triploid and pentaploid hybrids yielded three DNA fragments (1200, 900, and 750 bp). The 1200 bp fragment of the allotetraploid crucian carp, triploid, tetraploid, pentaploid hybrids of red crucian carp blunt snout bream shared 99.5%, 98.9%, 99.5%, and 88.7% homology, respectively, with the maternal DNA. The 900 bp fragment shared 97.5%, 94.6%, 94.2%, and 89.9% homology, respectively. Our results suggest that inheritance is maternally dominated. Furthermore, we observed preferential elimination of the paternal sequences in the allotetraploid hybrids. Based on these sequence analyses we constructed a phylogenetic tree to explain the relationships among the different ploidy levels. | Liangguo Liu 1, Cuiping You 1, Shaojun Liu , Huan Zhong, Dong Liu, Zhen Liu, Min Tao, Yun Liu Key Laboratory of Protein Chemistry and Fish Developmental Biology of National Education Ministry, College of Life Sciences, Hunan Normal University, Changsha 410081, China | 2009 | Progress in Natural Science:Materials International2009，19，9： | 0 |
| 5 | Bound states in the continuum in all-dielectric metasurfaces with scaled lattice constants显示文摘Bound states in the continuum(BICs)have emerged as an efficient tool for trapping light at the nanoscale,promising several exciting applications in photonics.Breaking the structural symmetry has been proposed as an effective way of exciting quasiBICs(QBICs)and generating high-Q resonances.Herein,we demonstrate that QBICs can be excited in an all-dielectric metasurface by scaling the lattice of the metasurface,causing translational symmetry breaking.The corresponding BICs arise from band folding from the band edge to the Γ point in the first Brillouin zone.Multipole analysis reveals that the toroidal dipole dominates these QBICs.Furthermore,scaling the lattice along different directions provides additional freedom for tailoring QBICs,enabling polarization-dependent or-independent QBICs.In addition,this allows the realization of two QBICs at different wavelengths using plane-wave illumination with different polarizations on the metasurface.We experimentally demonstrated the existence of these BICs by fabricating silicon metasurfaces with scaled lattices and measuring their transmission spectra.The vanished resonant linewidth identifies BICs in the transmission spectrum,and the QBICs are characterized by highQ Fano resonances with the Q-factor reaching 2000.Our results have potential applications in enhancing light-matter interaction,such as laser,nonlinear harmonic generation,and strong coupling. | Mimi Zhou Shaojun You Lei Xu Menghui Fan Jing Huang Wenbin Ma Mingzhe Hu Shengyun Luo Mohsen Rahmani Ya Cheng Lin Li Chaobiao Zhou Lujun Huang Andrey E.Miroshnichenko | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，12： | 0 |
| 6 | 血清白细胞介素-18和NO活性在前列腺癌患者的临床价值(英文)显示文摘Objective:The aim of the study was to estimate the clinical value of serum interleukin-18(IL-18)and nitric oxide(NO)activities in patients with prostate cancer.Methods:The 50 patients with prostate cancer and 25 control subjects were measured in serum IL-18 by enzyme-linked immunosorbent assay(ELISA)and nitrate+nitrite level by an index of NO generation.Results:Serum IL-18 and nitrate+nitrite levels were significantly higher in patients with prostate cancer when compared to the control subjects(P<0.05).Serum IL-18 level was significantly higher in patients with stages B,C and D when compared to patients with stage A(P<0.05).Serum IL-18 level was significantly higher in the metastatic patients compared with the nonmetastatic patients(P<0.01).There was no difference in serum nitrate and nitrite level between metastatic and nonmetastatic patients(P>0.05).The serum IL-18 and nitrate and nitrite levels decreased after patients underwent surgical resection.Conclusion:Serum IL-18 level may be a useful marker to predict prognosis of patients with prostate cancer after surgery.Long-term follow-up is required to clarify this hypothesis. | Shaojun Nong Yueping Zhang Chongsheng He Bin Cheng Shujun Zhou Wenguang Li Limin Ma You Wu | 2011 | The Chinese-German Journal of Clinical Oncology2011，10，12： | 0 |
| 7 | 前列腺癌患者血清白细胞介素-18和VEGF相关性(英文)显示文摘Objective: The aim of our study was to analyze interleukin-18 (IL-18) and vascular endothelial growth factor (VEGF) serum levels in patients with prostate cancer before and after operation and the possible correlation between IL-18 and VEGF serum levels. Methods: Serum IL-18 and VEGF levels were measured by enzyme-linked immunosorbent assay (ELISA) in 36 patients with prostate cancer before and after radical prostatectomy and in 25 healthy controls. Results: Serum IL-18 and VEGF levels were significantly higher in patients with prostate cancer before operation with respect to healthy controls (P < 0.05), with a highly significant correlation between IL-18 and VEGF (R = 0.800, P = 0.017). It was significantly reduced in IL-18 and VEGF after operation. IL-18 and VEGF serum concentrations were correlated with the clinicalopathological status of patients with prostate cancer. Conclusion: It is correlative with serum IL-18 and VEGF. Serum IL-18 and VEGF levels may be useful prognostic marker in patients with prostate cancer. | Shaojun Nong Yueping Zhang Shujun Zhou Wenguang Li Limin Ma You Wu | 2010 | The Chinese-German Journal of Clinical Oncology2010，9，11： | 0 |
| 8 | NetGO 3.0:Protein Language Model Improves Large-scale Functional Annotations显示文摘As one of the state-of-the-art automated function prediction(AFP)methods,NetGO 2.0 integrates multi-source information to improve the performance.However,it mainly utilizes the proteins with experimentally supported functional annotations without leveraging valuable information from a vast number of unannotated proteins.Recently,protein language models have been proposed to learn informative representations[e.g.,Evolutionary Scale Modeling(ESM)-1b embedding] from protein sequences based on self-supervision.Here,we represented each protein by ESM-1b and used logistic regression(LR)to train a new model,LR-ESM,for AFP.The experimental results showed that LR-ESM achieved comparable performance with the best-performing component of NetGO 2.0.Therefore,by incorporating LR-ESM into NetGO 2.0,we developed NetGO 3.0 to improve the performance of AFP extensively. | Shaojun Wang Ronghui You Yunjia Liu Yi Xiong Shanfeng Zhu | 2023 | Genomics, Proteomics & Bioinformatics2023，21，2： | 0 |
| 9 | Arabidopsis CAP1 mediates ammonium-regulated root hair growth by influencing vesicle trafficking and the cytoskeletal arrangement in root hair cells显示文摘Plant root hairs are essential for mineral and water absorption,which possess sophisticated sensory mechanisms to allow them to respond to different environmental signals.Ammonium(NH^(+))is a major form of nitrogen in the soil.NH^(+)can influence the root system architecture,such as root hair growth(Liu and von Wir en,2017). | Juanjuan Yu Xiaonan Ma Lianlian Wang Nannan Dong Kai Wang Qingye You Yifei Xu Chong Wang Zhiping Dong Zhaobin Shi Shaojun Dai Ling Bai Chun-Peng Song | 2022 | Journal of Genetics and Genomics2022，49，10： | 0 |
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