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| 1 | Tumor suppressor miR-128-3p inhibits metastasis and epithelial-mesenchymal transition by targeting ZEB1 in esophageal squamous-cell cancer显示文摘MicroRNAs (miRNAs ) 是在 post-transcriptional 层次调整多重生物功能的一些短 RNA,例如 tumorigenic 过程,煽动性的损害和房间 apoptosis。(ZEB1 ) 锌手指电子盒子有约束力的 homeobox 因素 1 是上皮间充质的转变(EMT ) 的一个关键调停人。它包括人的食道的有鳞房间的癌(ESCC ) 导致各种各样的癌症的恶意的前进。在这研究,我们发现 miR-128-3p 由使用 PCR 是在 ESCC 纸巾和房间的 downregulated。而且, miR-128-3p 的下面调整的表示被证明与 ESCC 病人的差的预后被联系并且可能被认为是一个独立预示的因素。然后,我们在 ESCC 房间检验了 miR-128-3p 的角色,并且发现 miR-128-3p 能在 vitro 压制房间迁居和侵略。而且, ZEB1 被证实是由酶记者试金的 miR-128-3p 的一个直接目标。营救实验证明 EMT 被 miR-128-3p 经由 ZEB1 的抑制调整。一起拿所有,我们断定 miR-128-3p 压制 EMT,经由 ZEB1 的转移,和 miR-128-3p 可以是在 ESCC 的一个批评调停人。 | Lili Zhao Rui Li Shanling Xu Yi Li Pei Zhao Wei Dong Zhenjun Liu Qian Zhao Bo Tan | 2018 | Acta Biochimica et Biophysica Sinica2018，50，2： | 21 |
| 2 | Low temperature conditioning reduces postharvest chilling injury in Ioquat fruit 显示文摘 | Cai C Xu C J ShanL L etal | 2006 | Postharvest Biology and Technology2006，41，： | 1 |
| 3 | Selectively targeting estrogen receptors for cancer treatment 显示文摘 | Shanle EK Xu W | 2010 | Adv Drug Deliv Rev2010，62，13： | 1 |
| 4 | Endocrine disrupting chemicals targeting estrogen receptor signaling:identification and mechanisms of action显示文摘 | Shanle EK Xu W | 2011 | Chem Res Toxicol2011，24，： | 1 |
| 5 | Endocrine disrupting chemicals tar-geting estrogen receptor signaling : Identification and mechanismsof action显示文摘 | ERIN K SHANLE XU W | 2011 | Chem Res Toxicol2011，24，1： | 1 |
| 6 | Endocrine disrupting chemicals targe- ting estrogen receptor signaling: identification and mechanisms of action 显示文摘 | SHANLE E K XU W | 2011 | Chem Res Toxicol2011，24，1： | 1 |
| 7 | Review endocrine disrupting chemicals targeting estrogen receptor signaling:identification and mechanisms of action显示文摘 | Shanle EK Xu W | 2011 | Chem Res Toxicol2011，24，1： | 1 |
| 8 | Selectively targeting estrogen receptors for cancer treatment显示文摘 | Shanle E K Xu W | 2010 | Adv Drug Deliv Rev2010，62，13： | 1 |
| 9 | Endocrine disrupting chemicals targeting estrogen receptor signaling:identification and mechanisms of action显示文摘 | Shanle EK Xu W | | 0，，： | 1 |
| 10 | Endocrine disrupting chemicals targeting estrogen receptor signaling:identification and mechanisms of action 显示文摘 | Shanle EK Xu W | 2011 | Chem Res Toxicol2011，24，1： | 1 |
| 11 | Efficacy of early prone or lateral positioning in patients with severe COVID-19:a single-center prospective cohort显示文摘Background:Position intervention has been shown to improve oxygenation,but its role in non-invasively ventilated patients with severe COVID-19 has not been assessed.The objective of this study was to investigate the efficacy of early position intervention on non-invasively ventilated patients with severe COVID-19.Methods:This was a single-center,prospective observational study in consecutive patients with severe COVID-19 managed in a provisional ICU at Renmin Hospital of Wuhan University from 31 January to 15 February 2020.Patients with chest CT showing exudation or consolidation in bilateral peripheral and posterior parts of the lungs were included.Early position intervention(prone or lateral)was commenced for>4 hours daily for 10 days in these patients,while others received standard care.Results:The baseline parameters were comparable between the position intervention group(n=17)and the standard care group(n=35).Position intervention was well-tolerated and increased cumulative adjusted mean difference of SpO_(2)/FiO_(2)(409,95%CI 86 to 733)and ROX index(26,95%CI 9 to 43)with decreased Borg scale(−9,95%CI−15 to−3)during the first 7 days.It also facilitated absorption of lung lesions and reduced the proportion of patients with high National Early Warning Score 2(≥7)on days 7 and 14,with a trend toward faster clinical improvement.Virus shedding and length of hospital stay were comparable between the two groups.Conclusions:This study provides the first evidence for improved oxygenation and lung lesion absorption using early position intervention in non-invasively ventilated patients with severe COVID-19,and warrants further randomized trials. | Zhong Ni Kaige Wang Ting Wang Yuenan Ni Wei Huang Ping Zhu Tao Fan Ye Wang Bo Wang Jun Deng Zhicheng Qian Jiasheng Liu Wenhao Cai Shanling Xu Yu Du Gang Wang Zongan Liang Weimin Li Jianfei Luo Fengming Luo Dan Liu | 2020 | Precision Clinical Medicine2020，3，4： | 0 |
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