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| 1 | Concurrent removal of intravitreal lens fragments after phacoemulsification with pars plana vitrectomy prevents development of retinal detachment显示文摘AIM: To evaluate the outcomes of 'concurrent vitrectomy' to retrieve dislocated lens fragment during phacoemulsification.METHODS: In a retrospective, observational case series, data of patients who underwent 'concurrent' pars plana vitrectomy(PPV) for dislocated lens fragments between the period 2000 and 2008 were reviewed. Data collected included patient demographics, pre-operative visual acuity, intra-operative occurrence of retinal breaks, duration of follow up, post-operative intraocular pressure, final best-corrected visual acuity(BCVA),presence of cystoid macular edema(CME) and occurrence of rhegmatogenous retinal detachment(RRD).· RESULTS: A total of 58 eyes of 58 patients were included in the study. At 12 mo the mean postoperative BCVA was log MAR 0.17(20/30) with a range of log MAR0 to 0.69(20/20 to 20/100), with 96.6%(56/58) of patients showing post- operative improvement in visual acuity(P =0.005). None of the patients developed postoperative retinal detachment, endophthalmitis or non-resolving uveitis at 12 mo.CONCLUSION: Our study results suggest concurrent PPV for retained lens fragments after cataract surgery is beneficial and may decrease the risk of glaucoma and prevent development of RRD. | Kakarla V Chalam Ravi K Murthy Joshua C Priluck Vijay Khetpal Shailesh K Gupta | 2015 | International Journal of Ophthalmology(English edition)2015，8，1： | 4 |
| 2 | Is laparoscopic colorectal cancer surgery equal to open surgery? An evidence based perspective显示文摘Laparoscopic colorectal surgery(LCS) is an evolving subject.Recent studies show that LCS can not only offer safe surgery but evidence is growing that this new technique can be superior to classical open procedures.Fewer perioperative complications and faster postoperative recovery are regularly mentioned when studies of LCS are presented.Even though the learning curve of LCS is frequently debated when limitations of laparoscopic surgeries are reviewed,studies show that in experienced hands LCS can be a safe procedure for colorectal cancer treatment.The learning curve however,is associated with high conversion rates and economical aspects such as higher costs and prolonged hospital stay.Nevertheless,laparoscopic colorectal cancer surgery(LCCR) offers several advantages such as less co-morbidity and less postoperative pain in comparison with open procedures.Furthermore,the good exposure of the pelvic cavity by laparoscopy and the magnification of anatomical structures seem to facilitate pelvic dissection laparoscopically.Moreover,recent studies describe no difference in safety and oncological radicalness in LCCR compared to the open total mesorectal excision(TME).The oncological adequacy of LCCR still remains unproven today,because long-term results do not yet exist.To date,only a few studies have described the results of laparoscopic TME combined with preoperative adjuvant treatment for colorectal cancer.The aim of this review is to examine the various areas of development and controversy of LCCR in comparison to the conventional open approach. | Beat M Künzli Helmut Friess Shailesh V Shrikhande | 2010 | World Journal of Gastrointestinal Surgery2010，2，4： | 3 |
| 3 | Cell-type specificity of β-actin expression and its clinicopathological correlation in gastric adenocarcinoma显示文摘AIM:To investigate cell type specific distribution ofβ-actin expression in gastric adenocarcinoma and its correlation with clinicopathological parameters.METHODS:β-actin is a housekeeping gene,frequently used as loading control,but,differentially expresses in cancer.In gastric cancer,an overall increased expression ofβ-actin has been reported using tissue disruptive techniques.At present,no histological data is available to indicate its cell type-specific expression and distribution pattern.In the present study,we analyzedβ-actin expression and distribution in paired normal and tumor tissue samples of gastric adenocarcinoma patients using immunohistochemistry(IHC),a tissue non-disruptive technique as well as tissue disruptive techniques like reverse transcriptase-polymerase chain reaction(RT-PCR)and western blotting.Correlation ofβ-actin level with clinicopathological parameters was done using univariate analysis.RESULTS:The results of this study showed significant overexpression,at both mRNA and protein level in tumor tissues as confirmed by RT-PCR(1.47±0.13 vs2.36±0.16;P<0.001)and western blotting(1.92±0.26 vs 2.88±0.32;P<0.01).IHC revealed thatβ-actin expression is majorly distributed between epithelial and inflammatory cells of the tissues.Inflammatory cells showed a significantly higher expression compared to epithelial cells in normal(2.46±0.13 vs 5.92±0.23,P<0.001),as well as,in tumor tissues(2.79±0.24 vs6.71±0.14,P<0.001).Further,comparison of immunostaining between normal and tumor tissues revealed that both epithelial and inflammatory cells overexpressβ-actin in tumor tissues,however,significant difference was observed only in inflammatory cells(5.92±0.23vs 6.71±0.14,P<0.01).Moreover,combined expression in epithelial and inflammatory cells also showed significant increase(4.19±0.15 vs 4.75±0.14,P<0.05)in tumor tissues.In addition,univariate analysis showed a positive correlation ofβ-actin level of inflammatory cells with tumor grade(P<0.05)while epithelial cells exhibited negative correlation(P>0.05).CONCLUSION:In gastric cancer,β-actin showed an overall higher expression predominantly contributed by inflammatory or tumor infiltrating immune cells of the tissue microenvironment and correlates with tumor grade. | Shafqat A Khan Monica Tyagi Ajit K Sharma Savio G Barreto Bhawna Sirohi Mukta Ramadwar Shailesh V Shrikhande Sanjay Gupta | 2014 | World Journal of Gastroenterology2014，20，34： | 2 |
| 4 | Low immune activation despite high levels of pathogenic human immunodeficiency virus type 1 results in long-term asymptomatic disease显示文摘 | Shailesh K Choudhary Nienke Vrisekoopm Christine A | 2007 | J Virol2007，81，16： | 1 |
| 5 | Foveal structure defined by spectral domain optical coherencetomography correlates with visual function after macular holesurgeiy显示文摘 | Kakarala V Ravi K Shailesh K Gupta B Vikram S Sandeep G | 2010 | Eur J Ophthalmol2010，20，3： | 1 |
| 6 | Hierarchical Fusion of Multiple Classifiers for Hyper-spectral Data Analysis显示文摘 | Shailesh K Joydeep G Melba M C | 2002 | Pattern Analysis & Application2002，5，2： | 1 |
| 7 | Cataplasm-based controlled drug delivery: Development and optimization of a novel formulation显示文摘 | Vikas A Shailesh K S Indra K R | 1999 | Drug Dev Ind Pharm1999，25，5： | 1 |
| 8 | Carbon nanotube supported MnO2 catalysts for oxygen reduction reac-tion and their applications in microbial fuel cells 显示文摘 | Min L Shailesh K How Y N | 2011 | Biosensors and Bioelectronics2011，26，： | 1 |
| 9 | 查看详情显示文摘 | Shailesh K D Rohit B Khanna A S | | 0，，： | 1 |
| 10 | Clinical and electrophysiological study of intermediate syndrome in patients with organophosphorous poisoning显示文摘 | Shailesh K K Pais P Vengamma B | 1994 | The Journal of the Association of Physicians of India1994，42，6： | 1 |
| 11 | Radiation-induced grafting of vinylbenzyl trimethyl ammonium chloride onto nylon-6 fabric 显示文摘 | SHAILESH M K ASHOK K | 2007 | Radiation Physics and Chemistry2007，76，5： | 1 |
| 12 | Performance of black pig -ments incorporated in interpenetrating polymer network(IPN) 显示文摘 | SHAILESH K DHOKE K M | 2006 | Prog Org Coat2006，，56： | 1 |
| 13 | Preparation and characterization of heat-resistant interpen- etrating polymer network ( IPN ) 显示文摘 | SHAILESH K DHOKE PALRAJ S MARUTHN K | 2007 | Progress in Coatings2007，59，1： | 1 |
| 14 | Acidic ionic liquid immo-bilized on cellulose ; An efficient and recyclable heterogeneous catalystfor the solventfree synthesis of hydroxylated trisubstituted pyridines显示文摘 | SHAILESH P S’PIYUSH N K DIPAK K R | 2013 | RSC Advances2013，3，： | 1 |
| 15 | Differential regulation of enolase during anaerobiosis in maize显示文摘 | SHAILESH K L Chwenfang L Martin M S | 1998 | Plant Physiol1998，118，： | 1 |
| 16 | On the Trade-offs between Risk Pooling and Logistics Costs in a Multi-plant Network with Commonality显示文摘 | MICHAEL J M AMITABH S R | 2005 | IIE Transactions2005，37，3： | 1 |
| 17 | Preparation and characteriza-tion of heat-resistant intel],enetrating polymer network(IPN)显示文摘 | Shailesh K D Palraj S Maruthan M S | 2007 | Progress in Organic Coatings2007，59，1： | 1 |
| 18 | Thermally stable organically modified layered silicates based on alkyl imidazolium salts显示文摘 | Shailesh K Goswami Smita G | 2012 | Journal of Colloid and Interface Science2012，368，1： | 1 |
| 19 | Nonalcoholic steatohepa- titis:What we know in the new millennium显示文摘 | Stephen AH Shailesh K Kevin AL | 2002 | Gastroenterology2002，97，11： | 1 |
| 20 | Dif{ererntial regulation of enolase during anaerhiosis in Maize 显示文摘 | Shailesh K L Chwenfang L Martin M | 1998 | Plant Physiology1998，118，： | 1 |
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