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| 1 | Phytochemical and biological activities of Crataegus sinaica growing in Egypt显示文摘Objective:To evaluate the cardiac activity and hepatoprotection of Crataegus sinaica (C.sinaica).Methods:All the isolated compounds were isolated by open-column liquid chromatography(CC) using sephadex LH-20 as stationary phase.Elution of the column was performed with EtOH or MeOH.The phytochemical investigation of the young stem of C.sinaica for the first time together with the leaves and flowers lead to the isolation and identification of quercetin,hyperoside,vitexin-2'-0-rhamnoside,epicatechin,procyanidin B2 and procyanidins CI.Results:Rats treated with the low and high dose of C.sinaica leaves with flowers extract showed 15%and 17%reduction in the heart rate,and reduction in the STsegment by 107%and 57%;respectively.The T-amplitude was decreased by 59%of the high dose extract.On the other hand,the young steins and leaves with flowers extracts of C.sinaica on primary culture of rat hepatocytes monolayer indicated a hepatoprotection for the total extract,ethyl acetate,butanol,and chlor of orm fractions at 100μg/mL,75μg/mL,50μg/mL,and 25μg/mL; respectively.Conclusions:The results of these chemical and biological studies suggest the use of C.sinaica growing in Egypt as a preventive drug against cardiovascular and hepatic diseases. The chemical studies suggest the use of woody young stems as a newly investigated bioactive organ.The extraction of unsaturated fatty acids from the seeds of the plant would serve as a good health and nutritive product. | Alaa Tawfeek Refaat Abdelaaty Abdelaziz Shahat Nermine Ahmed Ehsan Nemat Yassin Faiza Hammouda Elsayed Abou Tabl Shams Imbabi Ismail | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，4： | 2 |
| 2 | Continuous ambulatory peritoneal dialysis in insulin-dependent diabetes patients a 40 month experience显示文摘 | Shahat Y Agrafiotis A | 1983 | Kidney Int1983，23，1： | 1 |
| 3 | Significance of Rumex vesicarius as anticancer remedy against hepatocellular carcin- oma: a proposal-based on experimental animal studies 显示文摘 | Shahat A A Alsaid M S Kotob S E | 2015 | Asian Pac J Cancer Prev2015，36，10： | 1 |
| 4 | Isolation and NMR spectra of syringaresinol-β-D-glucoside from Cressa cretica 显示文摘 | Shahat A A Abdel-Azim N S Pieters L etal | 2004 | Fitoterapia2004，75，78： | 1 |
| 5 | Structur- al characterization of flavonol di-O-glycosides from Farsetiaaegyp- tia by electrospray ionization and collision-induced dissociation mass spectrometry 显示文摘 | Abdelaaty A Shahat Filip Cuyckens Wu Wang | 2005 | Rapid Commun Mass Spectrom2005，19，： | 1 |
| 6 | Mesoporous aluminosilica mon- oliths for the adsorptive removal of small organic pollutants显示文摘 | EI-Safty S A Shahat A Ismael M | 2012 | Journal of Hazardous Materials2012，02，： | 1 |
| 7 | Meso- porous aluminosilica monoliths for the adsorptive removal of small organic pollutants显示文摘 | Sherif A El-Salty Ahmed Shahat Mohamed Ismael | 2012 | J Hazard Mater2012，，02： | 1 |
| 8 | Comorbidities associated with psoriasis: An experience from the Middle East显示文摘 | NawafAL‐MUTAIRI ShahatAL‐FARAG AhmedAL‐MUTAIRI MazenAL‐SHILTAWY | 2010 | The Journal of Dermatology2010，，： | 1 |
| 9 | Investigation of the volatile oils,lipid constituents and biological activity of Ballota andreuzziana,Teucrium zanonii and Verbena tenuisecta in Libya显示文摘Objective:To determine the chemical composition of essential oils and lipid constituents of Ballola andreuzziana(B.andreuzziana),Teucrium zanonii(T.zanonii) and Verbena tenuisecta(V. tenuisecta) growing in Libya,and to test the antibacterial activity of different extracts of Teucrium zanonii.Methods:The volatile oils of all plants were extracted by hydrodistillation method and analyzed by GC/MS method.The lipid constituents of plants were obtained by extraction with petroleum ether and fractionated into fatty alcohols,fatty acids and unsapoinfiable matters. Antibacterial activity of T.zanonii extracts and antioxidant activity of different extracts of T. zanonii were also studied.Results:The volate oil of B.andreuzziana was found to consists of 20 compounds in which caryophyllin is the main one(63.1%),the volatile oil of T.zanonii consists of 74 compounds in which germacrene-D was the main compound,while the volatile oil of V. tenuisecta consists of 13 compounds with l-octen-3- ol as a major constituent(52.87%).The study of antimicrobial activity of different extracts of V.tenuisecta showed that,both methanol and butanol extracts exhibited the highest activity against Mycobacterium phlei(M.pblei) and Candida albicans(C.albicans) respectively,while petroleum ether,fatty alcohols and unsaponifiable fractions had no antimicrobial activity against all the tested microorganisms. Investigation of the antioxidant activity of different extracts of T.zanonii using DPPH method proved that,the ethyl acetate and butanol fractions showed the highest activity where the inhibition percentage(1%) are 93.6 and 92.1 respectively.Conclusions:This is the first report about the volatile oils of these plants where T.zanonii have the highest content and the highest number of the identified compounds.The study of antioxidant T.zanonii extracts proved that,the ethyl acetate,butanol and aqueous extracts have the highest antioxidant activity.Methanol and butanol extracts of V.tenuisecta exhibited the highest activity against M.phlei and C.albicans respectively. | Khaled A Abdelshafeek Adnan A Elgattar Aziza H Zarkoon Mohamed A Alwahash Abdelaaty A Shahat | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，8： | 1 |
| 10 | Antiviral and antioxidant activity of flavonoids and proanthocyanidins from Crataegus sinaica显示文摘 | Shahat AA Cosp De BT | 2002 | Plant Med2002，68，6： | 1 |
| 11 | A comparative study between flattening filter-free beams and flattening filter beams in radiotherapy treatment显示文摘Flattening filter-free(FFF) beams generated by medical linear particle accelerators(linacs) have recently been used in radiotherapy clinical practice.FFF beams have fundamental physical parameter differences with respect to standard flattening filter(FF) beams,such that the generally used dosimetric parameters and definitions are not always viable.This study investigates dosimetric parameters for use in the quality assurance of FFF beams generated by medical linacs in radiotherapy.The main characteristics of the photon beams are analyzed using specific data generated by a Varian True Beam linac having both FFF and FF beams of 6 and 10 MV(megavolt) energy,respectively.Definitions for dose profile parameters are suggested,starting from the renormalization of the FFF with respect to the corresponding FF beam.From this point,the flatness concept is translated into one of 'un-flatness',and other definitions are proposed,maintaining a strict parallelism between FFF and FF parameter concepts.The quality controls used in establishing a quality assurance program when introducing FFF beams into the clinical environment are given,maintaining similarity to those used for standard FF beams,and recommendations for the introduction of FFF beams into clinical radiotherapy application for breast cancer patients are provided as an example for comparison between FFF and FF for dose distribution and coverage for a target volume.Although there are many advantages of using a FFF beam,especially for advanced radiotherapy techniques,there are a few limitations(e.g.,using a relatively higher energy photon beam for stereotactic radiotherapy(SRT),limited speed of current multileaf collimators(MLCs),and off-axis distance-dependent modulation in intensitymodulated radiation therapy(IMRT)) as well as challenges(e.g.,criteria for beam quality evaluation and penumbra,establishment of dosimetry methods,and consequences of photon target burn-up) that need to be addressed for establishing the FFF beam as a viable alternative to the FF beam. | Ali Wagdy Khaled EI Shahat Huda Ashry Amaal El Shershaby Ehab Abdo | 2017 | Oncology and Translational Medicine2017，3，6： | 1 |
| 12 | Highly stable nonionic fatliquors based on ethoxylated overused vegetable oils显示文摘 | Nashy Ghada A EL- Shahat H A Abo - Elwafa | 2011 | Journal of the American Oil Chem- ists Society2011，88，10： | 1 |
| 13 | Egyptian Herbal Drug Industry: Challenges and Future Pros- pects显示文摘 | ABDEL-AZIM N S SHAMS K A SHAHAT A A A | 2011 | Research Journal of Medicinal Plant2011，5，2： | 1 |
| 14 | Maximum power point genetic identification func- tion for photovoltaic system显示文摘 | SHAHAT A E | 2010 | IJRRAS32010，，3： | 1 |
| 15 | Antiviral and antioxidant ac- tivity of flavonoids and proanthocyanidins from Crataegus sinaica 显示文摘 | Shahat AA Cos P De Bruyne T | 2002 | Planta Med2002，68，6： | 1 |
| 16 | Anti-HIV activity of flavonoids and proanthocyanidins from Crataegus sinaica显示文摘 | A.A. Shahat S.I. Ismail F.M. Hammouda S.A. Azzam G. Lemière T. De Bruyne S. De Swaef L. Pieters A. Vlietinck | 1998 | Phytomedicine1998，，2： | 1 |
| 17 | Maternal serum leptin as a marker of preeclampsia显示文摘 | El Shahat AM Ahmed AB Ahmed MR | 2013 | Arch Gynecol Obstet2013，288，6： | 1 |
| 18 | The effect of use of dates on serum potassium in nondiabetic hemodialysis patients 显示文摘 | Siddiqi N El Shahat 0 Bokhari E | 2009 | Saudi J Kidney Dis Transpl2009，20，： | 1 |
| 19 | Anti - HIV activity of flavonoids and pr0anth0cyanidins from Crataegus sinaica显示文摘 | Shahat AA Ismail SI Hammouda FM | 1998 | Phytomedicine1998，5，2： | 1 |
| 20 | NAD(P)H: qninone oxidoreductase 1 inducer activity of someSaudi Arabian medicinal plants 显示文摘 | SHAHAT A A ALSAID M S ALYAHYA M A | 2013 | Planta Med2013，79，6： | 1 |
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