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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Peroxisome proliferator-activated receptor alpha induction of uncoupling protein 2protects against acetaminophen-induced liver toxicity显示文摘 | Patterson AD Shah YM Matsubara T Krausz KW Gonzalez FJ | 2012 | Hepatology2012，56，1： | 1 |
| 3 | Polylactic acid mesh recon- struction of the anterior iliac crest after bone harvesting reduces ear- ly postoperative pain after anterior cervical fusion surgery显示文摘 | Wang MY Levi AD Shah S | 2002 | Neu- rosurgery2002，51，2： | 1 |
| 4 | C-reactive protein and coronary heart disease: a critical review 显示文摘 | Casas JP Shah T Hingorani AD | 2008 | J Intern Med2008，264，4： | 1 |
| 5 | Implementation of Qb D approach to the RP-HPLC method development and validation of roflumilast in bulk and tablet dosage form:an application in degradation study显示文摘 | Shah AD Patel CN | 2014 | World J Pharm Pharm Sci2014，3，6： | 1 |
| 6 | Morphology, attenuation, size, and structure (MASS)criteria: Assessing response and predicting clinical outcome in metastatic renal cell carcino- ma on antiangiogenie targeted therapy显示文摘 | Smith AD Shah SN Rini BI | 2010 | A JR Am J Roent- genol2010，194，6： | 1 |
| 7 | Imaging of acute pulmonary em- boli显示文摘 | Khan A Cann AD Shah RD | 2004 | Thorac Surg Clin2004，14，： | 1 |
| 8 | A multicenter study of factors influencing eerebrospinal fluid shunt survival in infants and children 显示文摘 | Shah SS Hall M Slonim AD | 2008 | Neurosurgery2008，62，5： | 1 |
| 9 | C-reactive protein and coronary heart disease:predictivem test or therapeutic target?显示文摘 | Hingorani AD Shah T Casas JP | 2009 | Clin Chem2009，55，2： | 1 |
| 10 | Halonitroalkanes, halonitriles, haloamides, and N-nitrosamines: a critical review of nitrogenous disinfection byproduct formation pathways 显示文摘 | Shah AD Mitch WA | 2012 | Environ Sci Technol2012，46，： | 1 |
| 11 | Treatment of psoriasis with topical NG-monomethyl-L-arginine, an inhibitor of nitric oxide synthesis显示文摘 | Copeland P Shah SA | 2000 | Br J Dermatol2000，142，5： | 1 |
| 12 | hnpact of UV disinfection combined with chlorination/chloramination on the formation of halonitromethanes and haloacetonitriles in drinking water显示文摘 | Shah AD Dotson A D Linden K G | 2011 | Environmental Science & Technology2011，45，8： | 1 |
| 13 | C-reactive protein and coronary heart disease :a critical review显示文摘 | Casas JP Shah T Hingorani AD | 2008 | J Intern Med2008，264，4： | 1 |
| 14 | C-reactive protein and coronary heart disease a critical review显示文摘 | Casas JP Shah T Hingorani AD | 2008 | J Inter Med2008，，： | 1 |
| 15 | Lues maligna in early ttlV infection case report and review of the literalure显示文摘 | Tucker JD Shah S Jarell AD | 2009 | Sex Transm Dis2009，36，8： | 1 |
| 16 | C-reaction protein and coro- nary heart disease:a critical review显示文摘 | Casas JP Shah T Hingorani AD | 2008 | J Intern Med2008，264，4： | 1 |
| 17 | C-reactive protein and coronary heart disease:a critical review显示文摘 | Casas JP Shah T Hingoran AD | 2008 | J Intern Med2008，264，4： | 1 |
| 18 | Polylactie acid mesh Re-construction of the anterior iliac crest after bone harvesting reduces early postoperative pain after anterior cervical fu- sion surgery 显示文摘 | Wang MY Levi AD Shah S | 2002 | Neurosurgery2002，51，2： | 1 |
| 19 | C-reactive protein and coro-nary heart disease:a critical review显示文摘 | Casas JP Shah T Hingorani AD | 2008 | J Intern Med2008，264，4： | 1 |
| 20 | Acute effects of intravenous nesiritide oncardiac contractility in heart failure显示文摘 | Shah SJ Michaels AD | 2010 | J Cardiac Fail2010，16，： | 1 |
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