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| 1 | Assessment of lnc RNA GAS5, lnc RNA HEIH, lnc RNA BISPR and its m RNA BST2 as serum innovative non-invasive biomarkers: Recent insights into Egyptian patients with hepatitis C virus type 4显示文摘BACKGROUND Hepatitis C virus(HCV)infection and its consequent complications are undeniably a public health burden worldwide,particularly in Egypt.Emerging evidence suggests that many lncRNAs have relevant roles in viral infections and antiviral responses.AIM To investigate the expression profiles of circulating lncRNAGAS5,lncRNAHEIH,lncRNABISPR and mRNABST2 in naïve,treated and relapsed HCV Egyptian patients,to elucidate relation to HCV infection and their efficacy as innovative biomarkers for the diagnosis and prognosis of HCV GT4.METHODS One hundred and thirty HCV-infected Egyptian patients and 20 healthy controls were included in this study.Serum lncRNAs and mRNABST2 were measured using quantitative real-time polymerase chain reaction(qRT-PCR).RESULTS Our results indicated that serum lncRNAGAS5 and LncRNABISPR were upregulated,whereas mRNA BST2 and LncRNA HEIH were downregulated in naïve patients.In contrast,HCV patients treated with sofosbuvir and simeprevir;with sofosbuvir and daclatasvir;or with sofosbuvir,daclatasvir and ribavirin exhibited lower levels of lncRNAGAS5 and lncRNABISPR with higher mRNABST2 compared to naïve patients.Notably,patients relapsed from sofosbuvir and simeprevir showed higher levels of these lncRNAs with lower mRNABST2 compared to treated patients.LncRNAGAS5 and lncRNABISPR were positively correlated with viral load and ALT at P<0.001,whereas mRNABST2 was negatively correlated with viral load at P<0.001 and ALT at P<0.05.Interestingly,a significant positive correlation between lncRNA HEIH and AFP was observed at P<0.001.CONCLUSION Differential expression of these RNAs suggests their involvement in HCV pathogenesis or antiviral response and highlights their promising roles in diagnosis and prognosis of HCV. | Nourhan M El Samaloty Marwa I Shabayek Ramy S Ghait Shohda A El-Maraghy Sherine M Rizk Maha M El-Sawalhi | 2020 | World Journal of Gastroenterology2020，26，2： | 2 |
| 2 | A simulation model for the Kwai Chung container terminals in Hong Kong 显示文摘 | Shabayek A A Yeung W W | 2002 | European Journal of Operational Research2002，140，1： | 1 |
| 3 | Corneal biomechanical properties in normal, post-laser in situ keratomileusis and keratoconic eyes 显示文摘 | Ortiz D Pifiero D Shabayek MH | 2007 | J Cataract Refract Surg2007，8，： | 1 |
| 4 | Vaginal carriage and antibiotic susceptibility profile of group B Streptococcus during late pregnancy in Ismailia, Egypt显示文摘 | Sarah Ahmed Abd El-kawy Shabayek Salah Mohamed Abdalla Abouzeid M.H. Abouzeid | 2009 | Journal of Infection and Public Health2009，，2： | 1 |
| 5 | Corneal biomechanical properties in normal, post-laser in situ keratomileusis, and kera- toconic eyes显示文摘 | Ortiz D Pinero D Shabayek MH | 2007 | J Cataract Refract Surg2007，33，： | 1 |
| 6 | The risk of retinal detachment in high myopia after small incision coaxial phacoemulsification显示文摘 | Alio JL Ruiz-Moreno JM Shabayek MH | 2007 | Am J Ophthalmol2007，144，1： | 1 |
| 7 | Diagnostic Evaluation of Ap- optosis Inhibitory Gene and Tissue Inhibitor Matrix Metalloprotein- ase-2 in Patients with Bladder Cancer 显示文摘 | Eissa S Shabayek MI Ismail MF | 2010 | IUBMB Life2010，62，5： | 1 |
| 8 | Analysis of re- sults related to good and bad outcomes of Intacs implanta- tion for keratoconus correction 显示文摘 | Alio JL Shabayek MH Belda JI | 2006 | J Cataract Refract Surg2006，32，： | 1 |
| 9 | Intrastromal corneal ring segment implantation by femtosecond laser for keratoconus correc- tion显示文摘 | Shabayek MH Alio JL | 2007 | Ophthalmology2007，114，： | 1 |
| 10 | Intracorneal ring segments for keratoconus correction: Long-term follow-up显示文摘 | Jorge L. Alió Mohamed H. Shabayek Alberto Artola | 2006 | Journal of Cataract & Refractive Surgery2006，，6： | 1 |
| 11 | Corneal biomechanical properties in normal,post-laser in situ keratomileusis,and kera- toconic eyes显示文摘 | Ortiz D Pinero D Shabayek MH | 2007 | J Cataract Refract Surg2007，33，8： | 1 |
| 12 | A simulation model for the Kwai Chung container terminals in Hong Kong 显示文摘 | A A Shabayek W W Yeung | 2002 | European Jotrnal of Operalional Research2002，140，1： | 1 |
| 13 | Macrolide- and tetracycline-resistancedeterminants of colonizing group B streptococcus in women inEgypt显示文摘 | Shabayek S Abdalla S | 2014 | J Med Microbiol2014，63，10： | 1 |
| 14 | A Simulation Model for the Kwai Chung Container Terminals in Hong Kong显示文摘 | A A Shabayek W W Yeung | 2002 | European Journal of Operational Research2002，10，： | 1 |
| 15 | Plane turbulent wall jets in limited tailwater depth显示文摘 | Shabayek S A | 2011 | International Journal of Engineering&Technology2011，11，6： | 1 |
| 16 | A simulation model for the Kwai Chung container terminals in Hong Kong显示文摘 | SHABAYEK A A YEUNG W W | 2002 | Eur J Operation Res2002，，： | 1 |
| 17 | Vision based UAV attitude estimation: progress and insights显示文摘 | Shabayek A E R Demonceaux C Morel O | 2012 | Journal of In- telligent & Robotic Systems2012，65，1234： | 1 |
| 18 | Dynamic model for subcritical combining flows in channel junctions显示文摘 | Shabayek Shazy Steffler Peter Hicks Faye | 2002 | Journal of Hydraulic Engineering2002，128，9： | 1 |
| 19 | The rish of retinaldetachinent in high myopia after small incision coaxial phacoe-mulsification显示文摘 | Alio JL Ruiz-Moreno JM Shabayek MH | 2007 | Am J Ophthalmol2007，144，1： | 1 |
| 20 | A simulation model for the Kwai Chung container terminals in Hong Kong显示文摘 | SHABAYEK A A YEUNG W W | 2002 | European Journal of Operational Research2002，140，1： | 1 |
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