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| 1 | Artemisinin Biosynthesis in Non-glandular Trichome Cells of Artemisia annua显示文摘Artemisinin-based combination therapy(ACT)forms the first line of malaria treatment.However,the yield fluctuation of artemisinin has remained an unsolved problem in meeting the global demand for ACT.This problem is mainly caused by the glandular trichome(GT)-specific biosynthesis of artemisinin in all currently used Artemisia annua cultivars.Here,we report that non-GT cells of self-pollinated inbred A.annua plants can express the artemisinin biosynthetic pathway.Gene expression analysis demonstrated the transcription of six known pathway genes in GT-free leaves and calli of inbred A.annua plants.LC-qTOF-MS/MS analysis showed that these two types of GT-free materials produce artemisinin,artemisinic acid,and arteannuin B.Detailed IR-MALDESI image profiling revealed that these three metabolites and dihydroartemisinin are localized in non-GT cells of leaves of inbred A.annua plants.Moreover,we employed all the above approaches to examine artemisinin biosynthesis in the reported XL annua glandless(gl)mutant.The resulting data demonstrated that leaves of regenerated gl plantlets biosynthesize artemisinin.Codectively,these findings not only add new knowledge leading to a revision of the current dogma of artemisinin biosynthesis inannua but also may expedite innovation of novel metabolic engineering approaches for high and stable production of artemisinin in the future. | Rika Judd M.Caleb Bagley Mingzhuo Li Yue Zhu Caiyan Lei Seyit Yuzuak Mans Ekelof Gaobin Pu Xiting Zhao David C.Muddiman De-Yu Xie | 2019 | Molecular Plant2019，12，5： | 5 |
| 2 | Thermal entanglement in the mixed three-spin XXZ Heisenberg model on a triangular cell显示文摘We numerically investigate the thermal entanglements of spins(1/2, 1) and spins(1/2, 1/2) in the three-mixed(1/2, 1,1/2) anisotropic Heisenberg XXZ spin system on a simple triangular cell under an inhomogeneous magnetic field. We show that the external magnetic field induces strong plateau formation in the pairwise thermal entanglement for fixed parameters of the Hamiltonian in the cases of ferromagnetic and antiferromagnetic interactions. We also observe an unexpected critical point at finite temperature in the thermal entanglement of spins(1/2, 1) for the antiferromagnetic case, while the entanglement of spins(1/2, 1) in the ferromagnetic case and the entanglement of spins(1/2, 1/2) in both ferromagnetic and antiferromagnetic cases almost decay exponentially to zero with increasing temperature. The critical point in the entanglement of spins(1/2, 1) in the antiferromagnetic case may be a signature of the quantum phase transition at finite temperature. | Seyit Deniz Han Ekrem Aydiner | 2014 | Chinese Physics B2014，23，5： | 5 |
| 3 | The Arabidopsis MYB5 transcription factor regulates mucilage synthesis, seed coat development, and trichome morphogenesis显示文摘 | Li SF Milliken ON Pham H Seyit R Napoli R Preston J Koltunow AM Parisha RW | 2009 | Plant Cell2009，21，1： | 1 |
| 4 | The comparative effects of valsartan and amlodipine on v Wf levels and N/L ratio in patients with newly diagnosed hypertension显示文摘 | Karaman M Balta S Seyit Ahmet AY | 2013 | Clin Exp Hypertens2013，35，7： | 1 |
| 5 | Convergence theorem for I-asymptotically quasi-nonexpansive mapping in Hilbert space 显示文摘 | Seyit T Ozlem G | 2007 | Journal of Mathematical Analysis and Applications2007，329，1： | 1 |
| 6 | Factors affecting the relationship between rate of loading and measured compressive strength of concrete 显示文摘 | Seyit A K | 1980 | Magazine of Concrete Research1980，32，11： | 1 |
| 7 | A new method to estimate Weibull parameters for wind energy applications 显示文摘 | Akdag Seyit A Dinler Ali | 2009 | Energy Conversion and Management2009，50，7： | 1 |
| 8 | Effect of Melatonin on Lipid Peroxidation,Glutathione and Glutathione Dependent Enzyme Activities in Experimental Otitis Media with Effusion in Guinea Pigs显示文摘 | Seyit Han T Harun U Mahfuz E | 2005 | Journal of Pineal Research2005，39，3： | 1 |
| 9 | Free vibration of super elliptical plates with constant and variable thickness by Ritz method显示文摘 | Seyit C Gulay A | 2009 | Journal of Sound and Vibration2009，319，12： | 1 |
| 10 | A new method to estimate Weibull parameters for wind energy applications显示文摘 | Seyit A A Dinler A | 2009 | Energy Conversion and Management2009，，50： | 1 |
| 11 | Piezoelectric properties of Sb-, Li-, and Mn-substituted Pb- (Zrx Ti1-x ) O3-Pb ( Zn1/3 Nb2/3 ) O3 -Pb ( Ni1/3 Nb2/3 ) O3 ceramics for high-power applications显示文摘 | Seung-Ho Park Seyit Ural Cheol-Woo Alan | 2006 | Jpn J Appl Phys2006，45，4： | 1 |
| 12 | Determinants of Entry in Turkish Manufacturing Industries显示文摘 | Burak Günalp Seyit Mümin Cilasun | 2006 | Small Business Economics2006，，： | 1 |
| 13 | Convergence theorem for I-asymptotically quasi-nonexpansive mapping in Hilbert space 显示文摘 | SEYIT T OZLEM G | 2007 | J Math Anal Appl2007，329，2： | 1 |
| 14 | A new method to estimate Weibull parameters for wind energy applications显示文摘 | Seyit A Akdaga Dinler A | | 0，，50： | 1 |
| 15 | Free vibration of super elliptical plates with constant and variable thickness by Ritz method显示文摘 | SEYIT C ALTAY G | | 0，，1： | 1 |
| 16 | Hybrid molecular structure of the giant protease tripeptidyl peptidase II 显示文摘 | Chuang CK Rockel B Seyit G | 2010 | Nat Struct Mol Biol2010，17，8： | 1 |
| 17 | Comparison of aromatase inhibitor (letrozole) and immunomodulators (infliximab and etanercept) on the regression of endometriotic implants in a rat model显示文摘 | Seyit Temel Ceyhan Onder Onguru Ulas Fidan | | 0，，01： | 1 |
| 18 | Alveolar echinococcosis localized in the liver, lung and brain显示文摘 | Seyit Mehmet Kayacan Sezai Vatansever Suleyman Temiz Bora Uslu Dilek Kayacan Vakur Akkaya Osman Erk Bülent Saka Aytac Karadag Kultigin Turkmen Fatih Yakar Kerim Guler | 2008 | Chinese Medical Journal2008，，1： | 1 |
| 19 | Comparison of the mobilization and proprioceptive neuromuscular facilitationethods in the treatment of shoulder impingement syndrome显示文摘 | SEYIT ITAKEP HANIFEG L TASKIPAN H LYA AKDUI | 2005 | The PainCIinic2005，，： | 1 |
| 20 | Factors affecting the relationship between rate of loading and Measured compressive strength of concrete 显示文摘 | Seyit All Kaplan | 1980 | Magazine of Concrete Research1980，23，111： | 1 |
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