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| 1 | Prognostic role of sensitive-to-apoptosis gene expression in rectal cancer显示文摘AIM:To investigate the association between prognosis of rectal cancer treated with chemoradiotherapy(CRT) and expression of sensitive-to-apoptosis(SAG),B-cell lymphoma-extra large(Bcl-X L) and Bcl-2 homologous antagonist/killer(Bak).METHODS:Real-time quantitative polymerase chain reaction was used to determine the expression of proteins of interest,namely SAG,Bcl-X L,Bak and β-actin,in rectal carcinoma patients who had a follow-up period of 3 years after CRT.Biopsy specimens were excised from the rectal tumor preceding CRT.RESULTS:SAG,Bcl-X L and Bak proteins showed significant correlations with each other.In multivariate analysis,patients with high vs low SAG expression showed a statistically significant difference in 2-year survival rates:56% vs 73%,respectively(P = 0.056).On the other hand,there were no significant correlations between the expression levels of all three genes and metastatic rates or tumor responses to CRT.Mean overall survival in the patients with elevated SAG expression was 27.1 mo ± 3.9 mo [95% confidence interval(CI):19.3-34.9],and in patients with reduced expression,it was 32.1 mo ± 2.5 mo(95% CI:27.3-36.9).The corresponding values for Bcl-X L were 28.0 mo ± 4.1 mo(95% CI:19.9-36.1) and 31.7 mo ± 2.9 mo(95% CI:26.0-37.5),and those for Bak were 29.8 mo ± 3.7 mo(95% CI:22.5-37.2) and 30.6 mo ± 2.4 mo(95% CI:25.5-35.0),respectively.CONCLUSION:Two-year survival rates significantly correlated with low SAG expression,and SAG may be a candidate gene for good prognosis,independent of therapeutic response of different individuals. | Sevgi A Ozden Hazan Ozyurt Zerrin Ozgen Olca Kilinc Mustafa Oncel Aylin E Gul Nimet Karadayi Nedime Serakinci Beki Kan Oya Orun | 2011 | World Journal of Gastroenterology2011，17，44： | 6 |
| 2 | Topical antimicrobialsfor burn infections-an update 显示文摘 | Sevgi M Toklu A Vecchio D | 2013 | Recent Pat AntiinfectDrug Discov2013，8，3： | 1 |
| 3 | An integrated maritime surveillance system based on high-frequency surface-wave radars 显示文摘 | Sevgi L Ponsford A Chan H C | 2001 | IEEE Antennas and Propagation Magazine2001，43，4： | 1 |
| 4 | Determination of amlodipine in human plasma by high-performance liquid chromatography with fluorescence detection 显示文摘 | SEVGI T SEDEF A | 2001 | J Chronmtogr B2001，758，2： | 1 |
| 5 | An integrated maritime surveillance system based on high-frequency surface-wave radars显示文摘 | SEVGI L PONSFORD A CHAN H C | 2001 | IEEE Antennas and Propagation Magazine2001，43，4： | 1 |
| 6 | An experiment on the con-sistency of aggregated comparison matrices in AHP显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | EuropeanJournal of Operational Research2006，171，1： | 1 |
| 7 | An integrated maritime surveillance system based on high-frequency surface-wave radar, Part 1: theoretical background and numerical simulations 显示文摘 | L Sevgi A Ponsford H C Chan | 2001 | IEEE Antennas and Propagation Magazine2001，43，4： | 1 |
| 8 | An integrated maritime surveillance system based on high-frequency surface-wave radar, Part 2: operational status and system performance 显示文摘 | A Ponsford L Sevgi H C Chan | 2001 | IEEE Antennas and Propagation Mag2001，43，5： | 1 |
| 9 | Evaluating the role of tutors in problem-based learning sessions显示文摘 | Sevgi Turana Melih Elcina Orhan Odabas? a | 2009 | Procedia Social and Behavioral Sciences 12009，，： | 1 |
| 10 | On determining cluster size of randomly deployed heterogeneous WSNs显示文摘 | SEVGI C KOCYIGIT A | 2008 | IEEE Communications Letters2008，12，4： | 1 |
| 11 | An integrated maritime sur- veillance system based on high-frequency surface-wave radars op- erational status and system performance显示文摘 | Ponsford A M Sevgi L Chan H C | 2001 | Antennas and Propagation Magazine2001，43，5： | 1 |
| 12 | An experiment on the consistency of aggregated comparison matrices in AHP显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | European Journal of Operational Research2006，171，1： | 1 |
| 13 | An integrat- ed maritime surveillance system based on high-fre- quency surface-wave radar, part I: theoretical back- ground and numerical simulations显示文摘 | SEVGI L PONSFORD A CHAN H C | 2001 | IEEE antennas and propagation magazine2001，43，4： | 1 |
| 14 | An experiment on the consistency of aggregated comparison matrices in AHP 显示文摘 | Rhonda A H Sevgi E Joshua M | 2006 | European Journal of Operational Research2006，171，1： | 1 |
| 15 | Effects of some emollients on the transmission of ultraviolet 显示文摘 | Emel F Sevgi A Tuma I | 2006 | Photodermatol Photoimmunol Photomed2006，22，2： | 1 |
| 16 | An integrated maritime surveillance system based on high-frequency surface-wave radars,Part1:theoretical background and numerical simulations显示文摘 | Sevgi L Ponsford A Chan H C | 2001 | IEEE Antennas and Propagation Maganize2001，43，4： | 1 |
| 17 | An integrated maritime surveillance system based on high-frequency surface -wave radars, Part 1 : Theoretical background and numerical simulations 显示文摘 | Sevgi L Ponsford A Chan H C | 2001 | IEEE Antennas and Propagation2001，43，4： | 1 |
| 18 | An experiment on the consistency of aggregated compareson matrices in AHP显示文摘 | RHONDA A H SEVGI E JOSHUA M | | 0，，01： | 1 |
| 19 | An integrated maritime surveillance system based on high frequency surface-wave radars显示文摘 | Sevgi L Ponsford A Chan H C | | 0，，04： | 1 |
| 20 | Eye closure sen- sitivity and epileptic syndromes: A retrospec- tive study of 26 adult cases 显示文摘 | Sevgi EB Saygi S Ciger A | 2007 | Seizure2007，16，1： | 1 |
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