|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Primary hepatic carcinoid:A case report and literature review显示文摘Carcinoids are tumors derived from neuroendocrine cells and often produce functional peptide hormones.Approximately 54.5% arise in the gastrointestinal tract and frequently metastasize to the liver.Primary hepatic carcinoid tumors(PHCT) are extremely rare;only 95 cases have been reported.A 65-year-old man came to our attention due to occasional ultrasound findings in absence of clinical manifestations.His previous medical history,since 2003,included an echotomography of the dishomogeneous parenchymal area but no focal lesions.A computed tomography scan performed in 2005 showed an enhanced pseudonodular-like lesion of about 2 cm.Cholangio-magnetic resonance imaging identified the lesion as a possible cholangiocarcinoma.No positive findings were obtained with positron emission tomography.Histology suggested a secondary localization in the liver caused by a low-grade malignant neuroendocrine tumor.Immunohistochemistry was positive for anti chromogranin antibodies,Ki67 antibodies and synaptophysin.Octreoscan scintigraphy indicated intense activity in the lesion.Endoscopic investigations were performed to exclude the presence of extrahepatic neoplasms.Diagnosis of PHCT was established.The patient underwent left hepatectomy,followed by hormone therapy with sandostatine LAR.Two months after surgery he had a lymph nodal relapse along the celiac trunk and caudate lobe,which was histologically confirmed.The postoperative clinical course was uneventful,with a negative follow-up for hematochemical,clinical and radiological investigations at 18 mo post-surgery.Diagnosis of PHCT is based principally on the histopathological confi rmation of a carcinoid tumor and the exclusion of a non-hepatic primary tumor.Surgical resection is the recommended primary treatment for PHCT.Recurrence rate and survival rate in patients treated with resection were 18% and 74%,respectively. | Luigi Maria Fenoglio Sara Severini Domenico Ferrigno Giovanni Gollè Cristina Serraino Christian Bracco Elisabetta Castagna Chiara Brignone Fulvio Pomero Elena Migliore Ezio David Mauro Salizzoni | 2009 | World Journal of Gastroenterology2009，15，19： | 14 |
| 2 | Immunohistochemical evaluation of vitamin D receptor(VDR) expression in cutaneous melanoma tissues and four VDR gene polymorphisms显示文摘Objective:Vitamin D receptor(VDR)mediates vitamin D activity.We examined whether VDR expression in excised melanoma tissues is associated with VDR gene(VDR)polymorphisms.Methods:We evaluated VDR protein expression(by monoclonal antibody immunostaining),melanoma characteristics,and carriage of VDR-Fok I-rs2228570(C>T),VDR-Bsm I-rs1544410(G>A),VDR-ApaI-rs7975232(T>G),and VDR-TaqI-rs731236(T>C)polymorphisms(by restriction fragment length polymorphism).Absence or presence of restriction site was denoted by a capital or lower letter,respectively:'F'and'f'for Fok I,'B'and'b'for Bsm I,'A'and'a'for ApaI,and 'T'and't'for TaqI endonuclease.Seventy-four Italian cutaneous primary melanomas(52.1±12.7 years old)were studied;51.4% were stage Ⅰ,21.6% stage Ⅱ ,13.5% stage Ⅲ,and 13.5% stage Ⅳ melanomas.VDR expression was categorized as follows:100% positive vs.<100%;over the median 20%(high VDR expression)vs.≤20%(low VDR expression);absence vs.presence of VDR-expressing cells.Results:Stage I melanomas,Breslow thickness of<1.00 mm,level II Clark invasion,Aa heterozygous genotype,and AaTT combined genotype were more frequent in melanomas with high vs.low VDR expression.Combined genotypes BbAA,bbAa,AATt,BbAATt,and bbAaTT were more frequent in 100%vs.<100%VDR-expressing cells.Combined genotype AATT was more frequent in melanomas lacking VDR expression(odds ratio=14.5;P=0.025).VDR expression was not associated with metastasis,ulceration,mitosis>1,regression,tumor-infiltrating lymphocytes,tumoral infiltration of vascular tissues,additional skin and non-skin cancers,and melanoma familiarity.Conclusions:We highlighted that VDR polymorphisms can affect VDR expression in excised melanoma cells.Low VDR expression in AATT carriers is a new finding that merits further study.VDR expression possibly poses implications for vitamin D supplementation against melanoma.VDR expression and VDR genotype may become precise medicinal tools for melanoma in the future. | Francesco La Marra Giuseppe Stinco Cinzia Buligan Giovanni Chiriacò Diego Serraino Carla Di Loreto Sabina Cauci | 2017 | Cancer Biology & Medicine2017，14，2： | 5 |
| 3 | Bsm I(rs1544410) and Fok I(rs2228570) vitamin D receptor polymorphisms, smoking, and body mass index as risk factors of cutaneous malignant melanoma in northeast Italy显示文摘Objective:To investigate whether vitamin D receptor gene(VDR)Bsm I-rs1544410 and Fok I-rs2228570 polymorphisms,smoking duration,and body mass index(BMI)are risk factors for cutaneous melanoma,especially metastatic melanoma.Methods:We studied 120 cutaneous melanoma cases[68 stage I and II non-metastatic melanoma(NMet M)patients,plus 52Stage III and IV metastatic melanoma(Met M)patients],and 120 matching healthy controls from northeast Italy.VDR polymorphisms were measured by restriction fragment length polymorphism analysis.Absence or presence of Bsm I and Fok I restriction sites was denoted by'B'and'F'or by'b'and'f,'respectively.Results:VDR-Bsm I bb genotype was more frequent among Met M(32.7%)than among NMet M cases(13.2%),with odds ratio(OR)=3.18.Comparison of all melanoma patients vs healthy controls showed that the following biomarkers were at risk:≥20 years of smoking(OR=2.43);≥20 years of smoking combined with bb(OR=4.78),Bb+bb(OR=2.30),Ff(OR=3.04),and Ff+ff(OR=3.08);obesity(BMI>30Conclusions:Risk factors for cutaneous Met M include two VDR polymorphisms combined with smoking duration and obesity.Results suggest gene-environment implications in melanoma susceptibility and severity.Future studies in larger cohorts and in subjects with different genetic background are warranted to extend our findings. | Sabina Cauci Vincenzo Maione Cinzia Buligan Martina Linussio Diego Serraino Giuseppe Stinco | 2017 | Cancer Biology & Medicine2017，14，3： | 3 |
| 4 | Hepatitis C virus and non-Hodgkin's lymphomas:Metaanalysisof epidemiology data and therapy options显示文摘Hepatitis C virus(HCV) is a global health problem affecting a large fraction of the world's population: This virus is able to determine both hepatic and extrahepatic diseases. Mixed cryoglobulinemia, a B-cell 'benign' lymphoproliferative disorders, represents the most closely related as well as the most investigated HCVrelated extrahepatic disorder. Since this virus is able to determine extrahepatic [non-Hodgkin's lymphoma(NHL)] as well as hepatic malignancies(hepatocellular carcinoma), HCV has been included among human cancer viruses. The most common histological types of HCV-associated NHL are the marginal zone, the lymphoplasmacytic and diffuse large cell lymphomas. The role of the HCV in the pathogenesis of the B-cell lymphoproliferative disorders is confirmed also by the responsiveness of the NHL to antiviral therapy. The purpose of this review is to provide an overview of the recent literature and a meta analysis of the epidemiology data, to explain the role of HCV in the development of NHL's lymphoma. Furthermore, the possibility to treat these HCV-related NHL with the antiviral therapy or with other therapeutic options, like chemotherapy, is also discussed. | Gabriele Pozzato Cesare Mazzaro Luigino Dal Maso Endri Mauro Francesca Zorat Giulia Moratelli PietroBulian Diego Serraino Valter Gattei | 2016 | World Journal of Hepatology2016，8，2： | 3 |
| 5 | Venous Lower-Limb Evaluation in Patients With Acute Pulmonary Embolism显示文摘 | Fulvio Pomero Chiara Brignone Cristina Serraino Sergio Panzone Christian Bracco Elena Migliore Paola Dalmasso Paolo Cavallo Perin Luigi Maria Fenoglio | 2011 | Southern Medical Journal2011，，6： | 2 |
| 6 | Comparison of de novo tumours after liver transplantation with incidence rates from Italian cancer registries显示文摘 | U. Baccarani P. Piselli D. Serraino G.L. Adani D. Lorenzin M. Gambato A. Buda G. Zanus A. Vitale A. De Paoli C. Cimaglia V. Bresadola P. Toniutto A. Risaliti U. Cillo F. Bresadola P. Burra | 2009 | Digestive and Liver Disease2009，，1： | 2 |
| 7 | 接受心脏手术的成人患者的体质量指数与死亡率:全国研究的系统评价和荟萃分析显示文摘接受心脏手术的肥胖患者的发病率和死亡率较低,该现象显然不合理,相关机制不明。该研究试图确定在心脏手术中观察到的这个肥胖悖论是否归因于逆流行病学、偏倚或混杂因素。方法:从英国国家成人心脏外科登记处提取自2002年4月至2013年3月期间进行的所有心脏外科手术数据。同时对至2015年6月Medline,Embase,Scopus, | 刘莉 叶鹏 Mariscalco G Wozniak MJ Dawson AG Serraino GF Porter R Nath M Klersy C Kumar T Murphy GJ | 2017 | 中华高血压杂志2017，25，2： | 2 |
| 8 | Infection with Epstein-Barr virus and cancer:an epidemiological review显示文摘 | Serraino D Piselli P Angeletti C | 2005 | J Biol Regul Homeost Agents2005，19，12： | 1 |
| 9 | Pyrrolidine dithiocarbamate reduces the severity of cerulein - induced murine acute pancreatitis显示文摘 | 3Virlos I Mazzon E Serraino I | 2003 | Shock2003，20，6： | 1 |
| 10 | Prevalanee of infected patients and understaffing have a role in hepatitis C virus transmission in dialysis显示文摘 | Petrosillo N Gilli P Serraino D | 2001 | Am J Kindey Dis2001，37，： | 1 |
| 11 | Consumption of fruit, vegetables, and other food groups and the risk of nasopha- ryngeal carcinoma 显示文摘 | Polesel J Serraino D Negri E | 2013 | Cancer Causes Control2013，24，6： | 1 |
| 12 | Macronutrients, fatty acids, cholesterol and pancreatic cancer显示文摘 | Ersilia Lucenteforte Renato Talamini Cristina Bosetti Jerry Polesel Silvia Franceschi Diego Serraino Eva Negri Carlo La Vecchia | 2009 | European Journal of Cancer2009，，3： | 1 |
| 13 | Prevalence of infected patients and understaffing have a role in hepatitis C rirus tranmission in dialysis显示文摘 | Petrosillo N Gilli P Serraino D | 2001 | Am J Kidney Dis2001，37，： | 1 |
| 14 | Venous lower-limb evalu- ation in patients with acute pulmonary embolism显示文摘 | Pomero F Brignone C Serraino C | 2011 | South Med J2011，104，6： | 1 |
| 15 | Sexual behaviour of het- erosexual individuals with HIV infection naive for antiretroviral therapy in Italy 显示文摘 | Girardi E Aloisi MS Serraino D | 2001 | Sex Trans Infect2001，77，2： | 1 |
| 16 | Flaxseed supplementation and early markers of colpn carcinogenesis显示文摘 | Serraino M Thompson LU | 1992 | Cancer Lett1992，63，： | 1 |
| 17 | Protective effects of an thocyanins from blackberry in a rat model of acute lung inflammation 显示文摘 | Rossi A Serraino I Dugo P | 2003 | Free Radic Res2003，37，： | 1 |
| 18 | Protective effects of cyanidin - 3 - 0 - glueoside from blackberry extract against peroxynitrite - induced endothelial dysfunction and vascular failure显示文摘 | Serraino l Dugo L Dugo P | 2003 | Life Sci2003，73，9： | 1 |
| 19 | Epidemiological aspects of major opportunistic infections of the respiratory tract in persons with AIDS:Europe,1993-2000显示文摘 | Serraino D Puro V Boumis E | 2003 | AIDS2003，17，： | 1 |
| 20 | The metabolic syn- drome and risk of prostate cancer in Italy显示文摘 | Pelucchi C Serraino D Negri E | 2011 | Ann Epidemiol2011，21，11： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员