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| 1 | Clinical significance of hepatitis B e antigen level measurement during long-term lamivudine therapy in chronic hepatitis B patients with e antigen positive显示文摘AIM: To determine the changes of quantitative hepatitis B e antigen (HBeAg) that predicts early detection of non- response or breakthrough to long-term lamivudine (LAM) therapy.METHODS: Among HBeAg positive chronic hepatitis B patients who failed to achieve HBeAg seroconversion within 12 mo, we retrospectively analyzed 220 patients who had received LAM more than 24 mo. RESULTS: The mean duration of LAM therapy was 36 (range, 24-72) mo. HBeAg seroconversion after the first 12 mo of LAM therapy was achieved in 53 (24.1%) patients. Viral breakthrough was observed in 105 (47.7%) patients. To find out whether the changing patterns of HBeAg levels can predict the outcome of LAM therapy, we analyzed the reduction rates of HBeAg levels during LAM therapy. Using the decrease more than 90% of pretreatment HBeAg levels, the sensitivity and specificity of response were 96.2% and 70.1%, respectively. Patients were divided into 3 groups according to the reduction patterns of the decrease of quantitative HBeAg: decrescendo, decrescendo-crescendo, no change or fluctuating groups. The optimal time to predict non- response or breakthrough was the first 9 mo of therapy. At 9 mo of therapy, 49 (92.5%) of 53 patients who had achieved HBeAg seroconversion were included in the decrescendo group. On the contrary, in the no change or fluctuating group, only four (7.5%) had achieved HBeAg seroconversion. Among patients who did not show the continuous decrease of HBeAg levels at 9 mo, 95.2% (negative predictive value) failed to achieve HBeAg seroconversion.CONCLUSION: Almost all patients who failed to showa continuous decrease of HBeAg levels at 9 mo of LAM therapy were non-response or breakthrough. Therefore, monitoring changes of HBeAg levels during LAM therapy in HBeAg positive chronic hepatitis B may be valuable for identifying patients who are at high risk of non-response or breakthrough. | Jung Woo Shin Neung Hwa Park Seok Won Jung Byung Chul Kim Sung Ho Kwon Jae Serk Park In Du Jeong Sung-Jo Bang Do Ha Kim | 2006 | World Journal of Gastroenterology2006，12，41： | 7 |
| 2 | A gastrointestinal stromal tumor of the duodenum masquerading as a pancreatic head tumor显示文摘Gastrointestinal stromal tumor (GIST) represents the most common kind of mesenchymal tumor that arises from the alimentary tract. GIST is currently defined as a gastrointestinal tract mesenchymal tumor showing CD117 (c-kit protein) positivity at immunohistochemistry. Throughout the whole length of the gastrointestinal tract, GIST arises most commonly from the stomach followed by the small intestine, the colorectum, and the esophagus. Only 3%-5% of GISTs occur in the duodenum, and especially, if GIST arises from the C loop of the duodenum, it can be difficult to differentiate from the pancreas head mass because of its anatomical proximity. Here, we report a case of duodenal GIST, which was assessed as a pancreatic head tumor preoperatively. | Sung Ho Kwon Hee Jeong Cha Seok Won Jung Byung Chul Kim Jae Serk Park In Du Jeong Jong Hwa Lee Yang Won Nah Sung Jo Bang Jung Woo Shin Neung Hwa Park Do Ha Kim | 2007 | World Journal of Gastroenterology2007，13，24： | 4 |
| 3 | Development and Characterization of Gemcitabine-Resistant Pancreatic Tumor Cells显示文摘 | Ami N. Shah Justin M. Summy Jing Zhang Serk In Park Nila U. Parikh Gary E. Gallick | 2007 | Annals of Surgical Oncology2007，，12： | 2 |
| 4 | Weekly docetaxel as second-line chemotherapy in advanced non-small cell lung cancer: phase Ⅱ trial显示文摘 | Serke M Schoenfeld N Loddenkemper R | 2004 | Anticancer Res2004，24，2： | 1 |
| 5 | Second-line chemotherapy for advanced non-small cell lung cancer (NSCLC) with weekly versus three-weekly docetaxel: results of a randomized phase Ⅲ study 显示文摘 | Schuette W Nagel S Serke M | 2004 | Proc Am Soc Clin Oncol2004，23，： | 1 |
| 6 | Lithium storage properties of nanocrystalline Ni3Sn4 alloys prepared by mechanical alloying显示文摘 | Heon- Lee Young Serk - Jang Won | 2002 | J Power Sources2002，112，： | 1 |
| 7 | Lung cancer in young females显示文摘 | Lienert T Serke M Schonfeld N | | 0，，05： | 1 |
| 8 | Second-line chemotherapy for advanced non -small cell lung cancer (NSCLC) with weekly versus three-weekly docetaxel:results of a randomized phase Ⅲ study显示文摘 | Schuette W Nagel S Serke M | 2004 | Proc Am Soc Clin Oncol2004，23，： | 1 |
| 9 | Maspin overexpression cor-relates with increased expression of vascular endothelia 1growth factors A, C, and D in human ovarian carci-noma显示文摘 | Filiz B Derya G Serk E | 2008 | Pathol Res Pract2008，204，： | 1 |
| 10 | Oxidized low-density lipoprotein (oxLDL)-induced cell death in dorsal root ganglion cell cultures de- pends not on the lectin-like oxLDL receptor-1 but on the toll-like re-ceptor-4 显示文摘 | Nowieki M Muller K Serke H | 2010 | J Neurosci Res2010，88，2： | 1 |
| 11 | Secondline ch-emotherapy for advanced non-small cell lung cancer (NSCLC) with weekly versus three-weekly docetaxel:results of a randomized phase Ⅲ study显示文摘 | SCHUETTE W NAGEL S SERKE M | 2004 | Proc Am Soc Clin Oncol2004，23，： | 1 |
| 12 | Second-line chemotherapy for advanced non-small cell lung cancer (NSCLC) with weekly versus three-weekly docetaxel:results of a randomized phase Ⅲstudy显示文摘 | Schuette W Nagel S Serke M | 2004 | Proc Am Soc Clin Oncol2004，23，： | 1 |
| 13 | Diagnosis and staging of lung cancer 显示文摘 | SERKE M SCHONFELD N | 2007 | Dtsch Med Wochenschr2007，132，21： | 1 |
| 14 | Prolonged islet alloqraft using cultured isolated neonatal rat istets 显示文摘 | SERK J R | 1983 | Diabetes1983，，： | 1 |
| 15 | Immunomagnetic selection of CD +34 cells:factors influencing component purity and yield 显示文摘 | Hildebrandt M Serke S Meyer O | 2000 | Transfusion2000，40，5： | 1 |
| 16 | Immunomagnetic selection of CD34^+ cells: factors influencing component purity and yield 显示文摘 | Hildebrandt M Serke S Meyer O | 2000 | Transfusion2000，40，5： | 1 |
| 17 | Maspin overexpression cor-relates with increased expression of vascular endothelia 1growth factors A, C, and D in human ovarian carci-noma显示文摘 | Filiz B Derya G Serk E | 2008 | Pathol Res Pract2008，204，： | 1 |
| 18 | Antiwrinkle effect of adipose- derived stem cell: Activation of dermal fibroblast by secretory factors显示文摘 | Won Serk Kim Byung Soon Park | 2009 | Derm Sci2009，53，2： | 1 |
| 19 | Adjuvant therapy in early-stage non-small cell lung cancer显示文摘 | Serke M | 2009 | Front Radiat Ther Oncol2009，42，： | 1 |
| 20 | Diagnosis and staging of lung cancer显示文摘 | Serke M Schonfeld N | 2007 | Dtsch Med Wochenschr2007，132，21： | 1 |
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