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| 1 | Layer-by-layer deposition of bioactive layers on magnesium alloy stent materials to improve corrosion resistance and biocompatibility显示文摘Magnesium alloy is considered as one of the ideal cardiovascular stent materials owing to its good mechanical properties and biodegradability.However,the in vivo rapid degradation rate and the insufficient biocompatibility restrict its clinical applications.In this study,the magnesium alloy(AZ31B)was modified by combining the surface chemical treatment and in-situ self-assembly of 16-phosphonyl-hexadecanoic acid,followed by the immobilization of chitosan-functionalized graphene oxide(GOCS).Heparin(Hep)and GOCS were alternatively immobilized on the GOCS-modified surface through layer by layer(LBL)to construct the GOCS/Hep bioactive multilayer coating,and the corrosion resistance and biocompatibility were extensively explored.The results showed that the GOCS/Hep bioactive multilayer coating can endow magnesium alloys with an excellent in vitro corrosion resistance.The GOCS/Hep multilayer coating can significantly reduce the hemolysis rate and the platelet adhesion and activation,resulting in an excellent blood compatibility.In addition,the multilayer coating can not only enhance the adhesion and proliferation of the endothelial cells,but also promote the vascular endothelial growth factor(VEGF)and nitric oxide(NO)expression of the attached endothelial cells on the surfaces.Therefore,the method of the present study can be used to simultaneously control the corrosion resistance and improve the biocompatibility of the magnesium alloys,which is expected to promote the application of magnesium alloys in biomaterials or medical devices,especially cardiovascular stent. | Fan Gao Youdong Hu Guicai Li Sen Liu Li Quan Zhongmei Yang Yanchun Wei Changjiang Pan | 2020 | Bioactive Materials2020，5，3： | 12 |
| 2 | Photocatalytic CO2 reduction highly enhanced by oxygen vacancies on Pt-nanoparticle-dispersed gallium oxide显示文摘催化剂为解决精力和环境危机正在答应的 metal-oxide-based 上的 Photocatalytic 公司 2 减小由人类面对了。氧空缺(V 金属氧化物上的 o ) 被期望是在 metal-oxide-based 催化剂上影响 photocatalytic 公司 2 减小的效率的一个关键因素。然而,迄今为止的问题 V o 影响 photocatalytic 公司 2 减小仍然是未答复的。此处,我们报导那,在 V 与磅 nanoparticles 涂的 o -rich 镓氧化物( V o -rich Pt/Ga 2 O 3),公司2 photocatalytically 被归结为公司,吗与高度提高的公司进化评价( 21.0 摩尔湥??剏??椠楮楴瑡癩?瀠潲楶敤?楨桧爭獥汯瑵潩?汣浩瑡?楳畭慬楴湯?潦?桴?潤慭湩挠癯牥湩?慅瑳?楳?吠楨?瑳摵?湡瑬?瑬吗?? | Yun-Xiang Pan Zheng-Qing Sun Huai-Ping Cong Yu-Long Men Sen Xin Jie Song Shu-Hong Yu | 2016 | Nano Research2016，9，6： | 12 |
| 3 | Facilitating Lithium-Ion Diffusion in Layered Cathode Materials by Introducing Li^(+)/Ni^(2+) Antisite Defects for High-Rate Li-Ion Batteries显示文摘Li^(+)/Ni^(2+) antisite defects mainly resulting from their similar ionic radii in the layered nickel-rich cathode materials belong to one of cation disordering scenarios.They are commonly considered harmful to the electrochemical properties,so a minimum degree of cation disordering is usually desired.However,this study indicates that LiNi_(0.8)Co_(0.15)Al_(0.05)O_(2)as the key material for Tesla batteries possesses the highest rate capability when there is a minor degree(2.3%)of Li^(+)/Ni^(2+) antisite defects existing in its layered structure.By combining a theoretical calculation,the improvement mechanism is attributed to two effects to decrease the activation barrier for lithium migration:(1)the anchoring of a low fraction of high-valence Ni^(2+) ions in the Li slab pushes uphill the nearest Li^(+)ions and(2)the same fraction of low-valence Li^(+) ions in the Ni slab weakens the repulsive interaction to the Li^(+) ions at the saddle point. | Zhongfeng Tang Sen Wang Jiaying Liao Shuo Wang Xiaodong He Bicai Pan Haiyan He Chunhua Chen | 2019 | Research2019，，1： | 8 |
| 4 | A Review of Compression, Ventilation, Defibrillation, Drug Treatment, and Targeted Temperature Management in Cardiopulmonary Resuscitation显示文摘 | Jian Pan Jian-Yong Zhu Ho Sen Kee Qing Zhang Yuan-Qiang Lu | 2015 | Chinese Medical Journal2015，，4： | 4 |
| 5 | Low-cost and high-strength Mg-Al-Ca-Zn-Mn wrought alloy with balanced ductility显示文摘A novel low-cost Mg-Al-Ca-Zn-Mn-based alloy was developed to simultaneously improve its strength and ductility.The high yield strength of 411 MPa and the high elongation to failure of~8.9%have been achieved in the as-extruded Mg-1.3Al-1.2Ca-0.5Zn-0.6Mn(wt%)sample.Microstructure characterizations showed that the high strength is mainly associated with the ultra-fined dynamically recrystallized(DRXed)grains.Moreover,high-density dislocations in the un-DRXed region and nano-precipitates are distributed among theα-Mg matrix.The high ductility property can be ascribed to the high volume fraction of DRXed grains with a much randomized texture,as well as the formations of high-density subgrains in the un-DRXed grain regions. | Kun Yang Hucheng Pan Sen Du Man Li Jingren Li Hongbo Xie Qiuyan Huang Huajun Mo Gaowu Qin | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，7： | 3 |
| 6 | Long-term administration of salvianolic acid A promotes endogenous neurogenesis in ischemic stroke rats through activating Wnt3a/GSK3β/β-catenin signaling pathway显示文摘Stroke is the major cause of death and disability worldwide.Most stroke patients who survive in the acute phase of ischemia display various extents of neurological deficits.In order to improve the prognosis of ischemic stroke,promoting endogenous neurogenesis has attracted great attention.Salvianolic acid A(SAA)has shown neuroprotective effects against ischemic diseases.In the present study,we investigated the neurogenesis effects of SAA in ischemic stroke rats,and explored the underlying mechanisms.An autologous thrombus stroke model was established by electrocoagulation.The rats were administered SAA(10 mg/kg,ig)or a positive drug edaravone(5 mg/kg,iv)once a day for 14 days.We showed that SAA administration significantly decreased infarction volume and vascular embolism,and ameliorated pathological injury in the hippocampus and striatum as well as the neurological deficits as compared with the model rats.Furthermore,we found that SAA administration significantly promoted neural stem/progenitor cells(NSPCs)proliferation,migration and differentiation into neurons,enhanced axonal regeneration and diminished neuronal apoptosis around the ipsilateral subventricular zone(SVZ),resulting in restored neural density and reconstructed neural circuits in the ischemic striatum.Moreover,we revealed that SAA-induced neurogenesis was associated to activating Wnt3a/GSK3β/β-catenin signaling pathway and downstream target genes in the hippocampus and striatum.Edaravone exerted equivalent inhibition on neuronal apoptosis in the SVZ,as SAA,but edaravone-induced neurogenesis was weaker than that of SAA.Taken together,our results demonstrate that long-term administration of SAA improves neurological function through enhancing endogenous neurogenesis and inhibiting neuronal apoptosis in ischemic stroke rats via activating Wnt3a/GSK3β/β-catenin signaling pathway.SAA may be a potential therapeutic drug to promote neurogenesis after stroke. | Sen Zhang De-wen Kong Guo-dong Ma Cheng-di Liu Yu-jiao Yang Shan Liu Nan Jiang Zi-rong Pan Wen Zhang Ling-lei Kong Guan-hua Du | 2022 | Acta Pharmacologica Sinica2022，43，9： | 3 |
| 7 | Water model experiments of multiphase mixing in the top-blown smelting process of copper concentrate显示文摘We constructed a 1:10 cold water experimental model by geometrically scaling down an Isa smelting furnace. The mixing processes at different liquid heights, lance diameters, lance submersion depths, and gas flow rates were subsequently measured using the conductivity method. A new criterion was proposed to determine the mixing time. On this basis, the quasi-equations of the mixing time as a function of different parameters were established. The parameters of the top-blown smelting process were optimized using high-speed photography. An excessively high gas flow rate or excessively low liquid height would enhance the fluctuation and splashing of liquid in the bath, which is unfavorable for material mixing. Simultaneously increasing the lance diameter and the lance submersion depth would promote the mixing in the bath, thereby improving the smelting efficiency. | Hong-liang Zhao Pan Yin Li-feng Zhang Sen Wang | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，12： | 3 |
| 8 | Porothermoelastic response of an oil sand formation subjected to injection and micro-fracturing in horizontal wells显示文摘Stimulation of unconsolidated formations via horizontal wells has seen its vast implementation in the recent development of heavy oil reservoir to save the time and cost of preheating the reservoir before the steam-assisted gravity drainage(SAGD)process.A mathematical approach was proposed in this research that fully couples the hydraulic,mechanical and thermal responses of unconsolidated sandstone formations and also applies failure criteria for describing either shear dilation or tensile parting mechanism that generates microcracks.The approach was implemented to predict the porothermoelastic response of a pair of SAGD wells subject to injection and subsequent micro-fracturing using hot water.It was found that the predicted bottom hole pressures(BHPs)match closely with the field observed data.An elliptical dilation zone developed around the dual wells with relatively high pore pressure,porosity,permeability and temperature,implying good interwell hydraulic communication between both wells.The activation of microcracks dramatically accelerated the dissipation of pore pressure across the entire formation depth and also facilitated heat convection in between the dual wells,though to a lesser extent.In summary,the approach provides a convenient means to assist field engineers in the optimization of injection efficiency and evaluation of interference among multiple horizontal wells. | Botao Lin Han Meng Jingjun Pan Sen Chen | 2020 | Petroleum Science2020，17，3： | 2 |
| 9 | Exome sequencing reveals genetic architecture in patients with isolated or syndromic short stature显示文摘Short stature is among the most common endocrinological disease phenotypes of childhood and may occur as an isolated finding or in conjunction with other clinical manifestations.Although the diagnostic utility of clinical genetic testing in short stature has been implicated,the genetic architecture and the utility of genomic studies such as exome sequencing(ES)in a sizable cohort of patients with short stature have not been investigated systematically.In this study,we recruited 561 individuals with short stature from two centers in China during a 4-year period.We performed ES for all patients and available parents.All patients were retrospectively divided into two groups:an isolated short stature group(group I,n=257)and an apparently syndromic short stature group(group II,n=304).Causal variants were identified in 135 of 561(24.1%)patients.In group I,29 of 257(11.3%)of the patients were solved by variants in 24 genes.In group II,106 of 304(34.9%)patients were solved by variants in 57 genes.Genes involved in fundamental cellularprocess played an important role in the genetic architecture of syndromic short stature.Distinct genetic architectures and pathophysiological processes underlie isolated and syndromic short stature. | Xin Fan Sen Zhao Chenxi Yu Di Wu Zihui Yan Lijun Fan Yanning Song Yi Wang Chuan Li Yue Ming Baoheng Gui Yuchen Niu Xiaoxin Li Xinzhuang Yang Shiyu Luo Qiang Zhang Xiuli Zhao Hui Pan Mei Li Weibo Xia Guixing Qiu Pengfei Liu Shuyang Zhang Jianguo Zhang Zhihong Wu James R.Lupski Jennifer E.Posey Shaoke Chen Chunxiu Gong Nan Wu | 2021 | Journal of Genetics and Genomics2021，48，5： | 2 |
| 10 | Distributed Estimation of Oscillations in Power Systems: An Extended Kalman Filtering Approach显示文摘Online estimation of electromechanical oscillation parameters provides essential information to prevent system instability and blackout and helps to identify event categories and locations.We formulate the problem as a state space model and employ the extended Kalman filter to estimate oscillation frequencies and damping factors directly based on data from phasor measurement units.Due to considerations of communication burdens and privacy concerns,a fully distributed algorithm is proposed using diffusion extended Kalman filter.The effectiveness of proposed algorithms is confirmed by both simulated and real data collected during events in State Grid Jiangsu Electric Power Company. | Zhe Yu Di Shi Zhiwei Wang Qibing Zhang Junhui Huang Sen Pan | 2019 | CSEE Journal of Power and Energy Systems2019，5，2： | 2 |
| 11 | The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity显示文摘The adaptive immunity that protects patients from coronavirus disease 2019(COVID-19),caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),is not well characterized.In particular,the asymptomatic patients have been found to induce weak and transient SARS-CoV-2 antibody responses,but the underlying mechanisms remain unknown;meanwhile,the protective immunity that guide the recovery of these asymptomatic patients is elusive.Here,we characterized SARS-CoV-2-specific B-cell and T-cell responses in 10 asymptomatic patients and 64 patients with other disease severity(mild,n=10,moderate,n=32,severe,n=12)and found that asymptomatic or mild symptomatic patients failed to mount virus-specific germinal center(GC)B cell responses that result in robust and prolonged humoral immunity,assessed by GC response indicators including follicular helper T(TFH)cell and memory B cell responses as well as serum CXCL13 levels.Alternatively,these patients mounted potent virus-specific TH1 and CD8+T cell responses.In sharp contrast,patients of moderate or severe disease induced vigorous virus-specific GC B cell responses and associated TFH responses;however,the virus-specific TH1 and CD8+T cells were minimally induced in these patients.These results,therefore,uncovered the protective immunity in asymptomatic patients and also revealed the strikingly dichotomous and incomplete humoral and cellular immune responses in COVID-19 patients with different disease severity,providing important insights into rational design of effective COVID-19 vaccines. | Leiqiong Gao Jing Zhou Sen Yang Lisha Wang Xiangyu Chen Yang Yang Ren Li Zhiwei Pan Jing Zhao Zhirong Li Qizhao Huang Jianfang Tang Li Hu Pinghuang Liu Guozhong Zhang Yaokai Chen Lilin Ye | 2021 | Signal Transduction and Targeted Therapy2021，6，4： | 2 |
| 12 | Genome-wide study reveals an important role of spontaneous autoimmunity, cardiomyocyte differentiation defect and antiangiogenic activities in gender-specific gene expression in Keshan disease显示文摘 | He Shulan Tan Wuhong Wang Sen Wu Cuiyan Wang Pan Wang Bin Su Xiaohui Zhao Junjie Guo Xiong Xiang Youzhang | 2014 | Chinese Medical Journal2014，，1： | 2 |
| 13 | Studies on the flame propagation characteristic and thermal hazard of the premixed N2O/fuel mixtures显示文摘An experimental study was carried out to investigate the flame propagation and thermal hazard of the premixed N2O/fuel mixtures,including NH3,C3H8 and C2H4.The study provided the high speed video images and data about the flame locations,propagation patterns,overpressures and the quenching diameters during the course of combustion in different channels to elucidate the dynamics of various combustion processes.The onset decomposition temperature was determined using high-performance adiabatic calorimetry.It was shown that the order of the flame acceleration rate and thermal hazard was N2O/C2H4>N2O/C3H8>N2O/NH3. | Yu-yan Li Rong-pei Jiang Zhi-peng Li Sen Xu Feng Pan Li-feng Xie | 2020 | Defence Technology(防务技术)2020，16，3： | 1 |
| 14 | Fecal Nucleic Acid Test as a Complementary Standard for Cured COVID-19 Patients显示文摘To date,no vaccine or specific antiviral treatment is yet available for COVID-19.The most effective control measures for the disease mainly depend on early diagnosis,strict patient quarantine,and close contact monitoring[1].Thus,reliable and accurate diagnostic methods play a critical role in global disease control and prevention.Reverse transcription-polymerase chain reaction(RT-PCR)assays are widely used for the laboratory diagnosis of virus-borne diseases. | HAN Mei ZOU Jing Bo LI Huan WEI Xiao Yu YANG Song ZHANG Hui Zheng WANG Peng Sen QIU Qian WANG Le Le CHEN Yao Kai PAN Pin Liang | 2020 | Biomedical and Environmental Sciences2020，33，12： | 1 |
| 15 | Evidence on Invasion of Blood,Adipose Tissues,Nervous System and Reproductive System of Mice After a Single Oral Exposure:Nanoplastics versus Microplastics显示文摘Objective This study was designed to provide the evidences on the toxicokinetics of microplastics(MPs)and nanoplastics(NPs)in the bodies of mammals.Methods 100 nm,3μm,and 10μm fluorescent polystyrene(PS)beads were administered to mice once by gavage at a dose of 200 mg/kg body weight.The levels and change of fluorescence intensity in samples of blood,subcutaneous fat,perirenal fat,peritesticular fat,cerebrum,cerebellum,testis,and epididymis were measured at 0.5,1,2,and 4 h after administration using an IVIS Spectrum small-animal imaging system.Histological examination,confocal laser scanning,and transmission electron microscope were performed to corroborate the findings.Results After confirming fluorescent dye leaching and impact of pH value,increased levels of fluorescence intensity in blood,all adipose tissues examined,cerebrum,cerebellum,and testis were measured in the 100 nm group,but not in the 3 and 10μm groups except in the cerebellum and testis at 4 h for the 3μm PS beads.The presence of PS beads was further corroborated.Conclusion After a single oral exposure,NPs are absorbed rapidly in the blood,accumulate in adipose tissues,and penetrate the blood-brain/testis barriers.As expected,the toxicokinetics of MPs is significantly size-dependent in mammals. | YANG Zuo Sen BAI Ying Long JIN Cui Hong NA Jun ZHANG Rui GAO Yuan PAN Guo Wei YAN Ling Jun SUN Wei | 2022 | Biomedical and Environmental Sciences2022，35，11： | 1 |
| 16 | Achieving high strength above 400 MPa in conventionally extruded Mg-Ca-Zn ternary alloys显示文摘In this work,the role of Zn content in modifying the microstructure and mechanical properties of the Mg-1.2Ca-xZn(x=0.6,2.0 wt.%,named as XZ10-0 and ZX21-0,respectively)based alloys was studied,and it is found that the yield strength(YS)of the present Mg-(Zn)-Ca based alloys increases monotonically with increasing the Zn concentration,from~339 MPa in low-Zn content XZ10-0 sample to~406 MPa in high-Zn content ZX21-0 sample.Microstructure characterization shows that the enhanced YS can be attributed to the grain refinement,fine and dispersed nano-phases,a large number of lamellae structures,and the decrease of recrystallization fraction.TEM results show that the formation mechanism for the ultra-fine grains in present Mg-(Zn)-Ca based alloys can be attributed to the co-segregation of Ca and Zn elements at the grain boundary,as well as the dynamic nanoprecipitations.When the Zn content is high,the nano-phases in ZX21-0 sample belong to the Ca;Mg;Zn;ternary phases,which exert much higher thermal stability than the nano-sized Mg2 Ca binary phases formed in the low-Zn content XZ10-0 sample.The finer size and higher number density of the nano-Mg Zn Ca phases lead to the much finer grain size and sub-grain lamellae thickness in ZX21-0 sample,which thus results in the higher YS of~406 MPa. | DU Sen YANG Kun LI Man LI JingRen REN YuPing HUANG QiuYan PAN HuCheng QIN GaoWu | 2022 | Science China(Technological Sciences)2022，65，3： | 1 |
| 17 | Reflective feature location: knowledge in mind meets information in system显示文摘Locating code entities relevant to a feature(i.e., feature location) is an important task in software maintenance. Feature location is challenging due to the information gap between the developer's knowledge about a feature and the feature's implementation in the system. In this paper, we present a reflective feature location approach Re FLex to bridge this gap. Re FLex automatically computes a reflexion model between the developer's logical view of a feature and the feature's implemented view reverse-engineered from the code. It provides interactive reflection support for the developer to refine the logical view and the feature location results such that the logical view and the implemented view converge gradually in an iterative feature location process.We have implemented our approach as an Eclipse plugin and investigated the benefits and challenges in reflective feature location through a user study. | Xin PENG Zhengchang XING Sen PAN Wenyi QIAN Václav RAJLICH Wenyun ZHAO | 2017 | Science China(Information Sciences)2017，60，7： | 1 |
| 18 | Direction controllable inverse transition radiation from the spatial dispersion in a graphene-dielectric stack显示文摘Transition radiation(TR) induced by electron–matter interaction usually demands vast accelerating voltages, and the radiation angle cannot be controlled. Here we present a mechanism of direction controllable inverse transition radiation(DCITR) in a graphene-dielectric stack excited by low-velocity electrons. The revealed mechanism shows that the induced hyperbolic-like spatial dispersion and the superposition of the individual bulk graphene plasmons(GPs) modes make the fields, which are supposed to be confined on the surface, radiate in the stack along a special radiation angle normal to the Poynting vector. By adjusting the chemical potential of the graphene sheets, the radiation angle can be controlled. And owing to the excitation of bulk GPs, only hundreds of volts for the accelerating voltage are required and the field intensity is dramatically enhanced compared with that of the normal TR. Furthermore, the presented mechanism can also be applied to the hyperbolic stack based on semiconductors in the infrared region as well as noble metals in the visible and ultraviolet region.Accordingly, the presented mechanism of DCITR is of great significance in particle detection, radiation emission,and so on. | SEN GONG MIN HU ZHENHUA WU HANG PAN HAOTIAN WANG KAICHUN ZHANG RENBIN ZHONG JUN ZHOU TAO ZHAO DIWEI LIU WEI WANG CHAO ZHANG SHENGGANG LIU | 2019 | Photonics Research2019，7，10： | 1 |
| 19 | Research on Characteristic Parameters of Coal-dust Explosion显示文摘 | Weiguo Cao Liyuan Huang Jianxin Zhang Sen Xu Shanshan Qiu Feng Pan | 2012 | Procedia Engineering2012，，： | 1 |
| 20 | Safety of once-daily insulin detemir in patients with type 2 diabetes treated with oral hypoglycemic agents in routine clinical practice显示文摘 | Stuart Ross Grzegorz Dzida Qiuhe Ji Marcel Kaiser Robert Ligthehn Luigi Meneghini Avideh Nazeri Do- mingo Orozco-Behran Changyu Pan Anne Louise Svend- sen | 2014 | Journal of diabetes2014，6，3： | 1 |
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