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| 1 | SGLT-2 inhibitors in non-alcoholic fatty liver disease patients with type 2 diabetes mellitus: A systematic review显示文摘BACKGROUND Non-alcoholic fatty liver disease(NAFLD)is a common comorbidity with type 2 diabetes.The existing therapeutic options for NAFLD are not adequate.Hypocaloric diet and exercise is the cornerstone of therapy in NAFLD.Pioglitazone is the only drug recommended in diabetes patients with biopsy proven non-alcoholic steatohepatitis.The frequent coexistence of NAFLD and type 2 diabetes with their combined adverse health consequences and inadequate therapeutic options makes it necessary to search for newer alternatives.AIM To assess the effect of sodium glucose cotransporter-2(SGLT-2)inhibitors on liver enzymes in type 2 diabetes patients with NAFLD.METHODS We searched PubMed/MEDLINE,Cochrane library,Google scholar,and Clinicaltrials.gov for the relevant articles to be included in this systematic review.Human studies done in type 2 diabetes patients with NAFLD treated with SGLT-2 inhibitors for at least 12 wk were included.Data from eight studies(four randomised controlled trials and four observational studies)were extracted and a narrative synthesis was done.A total of 214 patients were treated with SGLT-2 inhibitors in these studies(94 in randomised controlled trials and 120 in observational studies).RESULTS The primary outcome measure was change in serum alanine aminotransferase level.Out of eight studies,seven studies showed a significant decrease in serum alanine aminotransferase level.Most of the studies revealed reduction in serum level of other liver enzymes like aspartate aminotransferase and gamma glutamyl transferase.Five studies that reported a change in hepatic fat exhibited a significant reduction in hepatic fat content in those treated with SGLT-2 inhibitors.Likewise,among the three studies that evaluated a change in indices of hepatic fibrosis,two studies revealed a significant improvement in liver fibrosis.Moreover,there was an improvement in obesity,insulin resistance,glycaemia,and lipid parameters in those subjects taking SGLT-2 inhibitors.The studies disclosed that about 17%(30/176)of the subjects taking SGLT-2 inhibitors developed adverse events and more than 40%(10/23)of them had genitourinary tract infections.CONCLUSION Based on low to moderate quality of evidence,SGLT-2 inhibitors improve the serum level of liver enzymes,decrease liver fat,and fibrosis with additional beneficial effects on various metabolic parameters in type 2 diabetes patients with NAFLD. | Henith Raj Harsh Durgia Rajan Palui Sadishkumar Kamalanathan Sandhiya Selvarajan Sitanshu Sekhar Kar Jayaprakash Sahoo | 2019 | World Journal of Diabetes2019，10，2： | 9 |
| 2 | The dawn of hedgehog inhibitors: Vismodegib显示文摘 | Selvarajan Sandhiya George Melvin Srinivasamurthy Kumar Steven Dkhar | 2013 | Journal of Pharmacology and Pharmacotherapeutics2013，，1： | 2 |
| 3 | Low Pressure DC Glow Discharge Air Plasma Surface Treatment of Polyethylene (PE) Film for Improvement of Adhesive Properties显示文摘The present work deals with the change in surface properties of polyethylene (PE) film using DC low pressure glow discharge air plasma and makes it useful for technical applications. The change in hydrophilicity of the modified PE film surface was investigated by measuring contact angle and surface energy as a function of exposure time. Changes in the morphological and chemical composition of PE films were analyzed by atomic force microscopy (AFM) and X-ray photoelectron spectroscopy (XPS). The improvement in adhesion was studied by measuring T-peel and lap-shear strength. The results show that the wettability and surface energy of the PE film has been improved due to the introduction of oxygen-containing polar groups and an increase in surface roughness. The XPS result clearly shows the increase in concentration of oxygen content and the formation of polar groups on the polymer surface. The AFM observation on PE film shows that the roughness of the surface increased due to plasma treatment. The above morphological and chemical changes enhanced the adhesive properties of the PE film surfaces, which was confirmed by T-peel and lap-shear tests. | Krishnasamy NAVANEETHA PANDIYARAJ Vengatasamy SELVARAJAN Rajendrasing R. DESHMUKH Coimbatore. Paramasivam YOGANAND Suresh BALASUBRAMANIAN Sundaram MARUTHAMUTHU | 2013 | Plasma Science and Technology2013，15，1： | 2 |
| 4 | Synthesis, antibacterial and anti-inflammatory activity of bis(indolyl)methanes显示文摘A series of bioactive bis(indolyl)methanes are synthesized by one-pot green reaction of indole with various substituted aldehydes by microwave irradiation under solvent free conditions. The antibacterial activity against Staphylococcus aureus and anti-inflammatory activity of the synthesized bis(indolyl)-methanes are evaluated in vitro and compared to standard drugs tetracycline and diclofenac,respectively. The majority of the compounds showed good antibacterial and anti-inflammatory activity.Interestingly, compounds 3j, 3i, 3k and 3g exhibited much higher anti-inflammatory activity than the standard diclofenac drug and thus qualify for clinical trials to be used as an anti-inflammatory compound. | Santhisudha Sarva Jayaprakash Soora Harinath Siva Prasad Sthanikam Selvarajan Ethiraj Mohanasrinivasan Vaithiyalingam Suresh Reddy Cirandur | 2016 | Chinese Chemical Letters2016，27，1： | 2 |
| 5 | Study of plasma and detonation gun sprayed alumina coatings using Tagnchi experimental design 显示文摘 | Saravanan P Selvarajan V Srivastava M P | 1999 | Journal of Thermal Spray Technology1999，9，4： | 1 |
| 6 | Antiinflammatory effects of genistein,a tyrosine kinase inhibitor,on a guinea pig model of asthma显示文摘 | Duan W Kuo IC Selvarajan S | 2003 | American journal of respiratory and critical care medicine2003，167，1： | 1 |
| 7 | Investigation of ring resonators in photonic crystal circuits显示文摘 | KUMAR V D SRINIVAS T SELVARAJAN A | 2004 | Photonics and Nanostructures-Fundamentals and Applications2004，2，3： | 1 |
| 8 | Effectof Critical Plasma Spray Parameter on Properties of HollowCathode Plasma Sprayed Alumina Coatings 显示文摘 | YUGESWARAN S’SELVARAJAN V’SEO D | 2008 | Surface &? Coatings Technology2008，203，： | 1 |
| 9 | Effect of DC glow discharge plasma treatment on PET/TiO2 thin film surfaces for enhancement of bioaetivity显示文摘 | Pandiyaraj K N Selvarajan V Rhee Y H | 2010 | Colloids and Surfaces B: Biointerfaces2010，79，： | 1 |
| 10 | Investigation of ring resonators in photonic crystalcircuits显示文摘 | DINESH K V SRINIVAS T SELVARAJAN A | 2004 | Photonics and Nanostructures - Funda- mentals and Applications2004，2，3： | 1 |
| 11 | Modification of surface properties of polypropylene(PP) film using DC glow discharge air plasma 显示文摘 | NAVANEETHA PANDIYARAJ K SELVARAJAN V DESHMUKH R R | 2009 | Applied Surface Science2009，255，7： | 1 |
| 12 | Electron number density measurement on a DC argon plasma jet by stark broadening of Ar I spectral line显示文摘 | S. Yugeswaran V. Selvarajan | 2006 | Vacuum2006，，3： | 1 |
| 13 | Microstructure, adhesion, microhardness, abrasive wear resista-ce and electrical resistivity of the plasma sprayed alumina and alumina-titania coatings 显示文摘 | RAMACHANDRAN K SELVARAJAN V ANANTHAPADMANABHAN P V SREEKUMAR K P | 1998 | Thin Solid Films1998，315，： | 1 |
| 14 | Synthesis of nanophase alumina, and spheroidization of alumina particles, and phase transition studies through DC thermal plasma processing显示文摘 | Suresh K Selvarajan V | 2008 | Vacuum2008，82，8： | 1 |
| 15 | Antecedents to temporary employee's turnover intention显示文摘 | Slattery J Selvarajan T | 2005 | Journal of Leadership and Organizational Studies2005，12，1： | 1 |
| 16 | A novel method of optical detection using a capacitive device显示文摘 | Paul Bipul Chandra Satyam M Selvarajan A | 1999 | IEEE Trans on Electron Devices1999，31，： | 1 |
| 17 | The effect of glow discharge plasma on the surface properties of Poly ( ethylene terephthalate) (PET) film 显示文摘 | PANDIYARAJ K N SELVARAJAN V DESHMUKH R R | 2008 | Surf Coat Technol2008，202，17： | 1 |
| 18 | Growth, structural, spectral, mechanical and dielectric character- ization of RbCl-doped L-alanine hydrogen chloride mono- hydrate single crystals 显示文摘 | Rose A S J L Selvarajan P Perumal S | 2011 | Physica B: Condensed Mat- ter2011，406，3： | 1 |
| 19 | Production, purification, characterization, immobilization, and application of Serrapeptase: a review显示文摘 | Selvarajan Ethiraj Shreya Gopinath | 2017 | Frontiers in Biology2017，12，5： | 1 |
| 20 | Design of a new family of two-dimensional codes for fiber-optic CDMA networks显示文摘 | SHIVALEELA E S SIVARAJAN K N SELVARAJAN A | 1998 | J Lightwave Technol1998，16，4： | 1 |
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