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	题名	作者	年代	出处	被引量
1	Interaction of repaglinide with bovine serum albumin:Spectroscopic and molecular docking approaches显示文摘Repaglinide (RPG) regulates the amount of glucose by stimulating the pancreas to release insulin in the blood. In view of its biological importance, we have examined the interaction between RPG and a model protein, bovine serum albumin (BSA) employing various spectroscopic, electrochemical and molecular docking methods. Fluorescence spectra of BSA were recorded in the presence and absence of RPG in phosphate buffer of pH 7.4. Fluorescence intensity of BSA was decreased upon the addition of increased concentrations of RPG, indicating the interaction between RPG and BSA. Stern-Volmer quenching analysis results revealed that RPG quenched the intensity of BSA through dynamic quenching mechanism. This was further confirmed from the time-resolved fluorescence measurements. The binding constant as calculated from the spectroscopic and voltammetric results was observed to be in the order of 104M-1 at 298 K, suggesting the moderate binding affinity between RPG and BSA. Competitive experimental results revealed that the primary binding site for RPG on BSA was site II. Absorption and circular dichroism studies indicated the changes in the secondary structure of BSA upon its interaction with RPG. Molecular simulation studies pointed out that RPG was bound to BSA in the hydrophobic pocket of site II.	Suma K.Pawar Seetharamappa Jaldappagari	2019	Journal of Pharmaceutical Analysis2019，9，4：	2
2	Fabrication of the electrochemically reduced graphene oxide-bismuth nanoparticles composite and its analytical application for an anticancer drug gemcitabine显示文摘The present study explores an electroreduced graphene oxide-bismuth nanoparticles composite(ErGOBi) as an electrochemical sensor for the determination of an anticancer drug, gemcitabine hydrochloride(GMB). The Er-GOBi interface was prepared by drop casting of bismuth nitrate-graphene oxide suspension on a glassy carbon electrode(GCE) followed by electro-reduction in the potential range of 0.6 V to 1.7 V. SEM, FTIR, EDAX and AFM techniques were employed for the characterization of prepared materials. Cyclic voltammetric and electrochemical impedance spectroscopic methods were used to understand the charge transfer properties of stepwise modification of Er-GOBi/GCE. GMB exhibited an irreversible oxidation peak at 1.144 V on Er-GOBi/GCE in phosphate buffer of p H 3. A 100-fold enhanced oxidation peak current was observed at Er-GOBi/GCE when compared to that at bare GCE.Sensing performance of Er GO-Bi/GCE was optimized by varying peak current dependent parameters.Linear relationship between the peak current and concentration of GMB was observed in the range of 0.1–51.1 mmol/L in differential pulse voltammetric method and 2.1–61.1 mmol/L in linear sweep voltammetric method. The practical utility of the proposed sensor, Er-GOBi/GCE was demonstrated by determining GMB in pharmaceutical formulations and spiked urine samples.	Ranjita Tandel Nagappa Teradal Ashis Satpati Seetharamappa Jaldappagari	2017	Chinese Chemical Letters2017，28，7：	2
3	Study of the interaction of an anticancer drug with human and bo- vine serum albumin: spectroscopic approach显示文摘	Kandagal P B Ashoka S Seetharamappa J	2006	J Pharm Biomed Anal2006，41，2：	1
4	Binding of trazodone hydrochloride with human serum albumin: A spectroscopic study 显示文摘	Kandagal P B Seetharamappa J Shaikh S M T	2007	J Photochem Photobiol A2007，185，：	1
5	A study of the interaction between bromopyrogallol red and bovine serum albumin by spectroscopic methods显示文摘	Shaikh S M T Seetharamappa J Ashoka S	2007	Dyes and Pigments2007，73，：	1
6	Shaikh Investigation of the Interaction Between Trasodone Hydrochloride and Bovine Serum Albumin显示文摘	Ashoka S Seetharamappa J Kandagal P B	2006	Journal of Luminescence2006，121，：	1
7	Study of the interaction of an anticancer drug with human and bovine serum albumin: Spectroscopic approach显示文摘	Kandagal P B Ashoka S Seetharamappa J	2006	J Pharmaceutical and Biomedical Anal2006，41，：	1
8	A study of the interaction between bromopyrogallol red and bovine serum albumin by spectroscopic methods 显示文摘	SHAIKH S M T SEETHARAMAPPA J ASHOKA S	2007	Journal of Molecular Structure2007，73，2：	1
9	Investigation of the in- teraction between trazodone hydrochloride and bovine serum albumin 显示文摘	Ashoka S Seetharamappa J Kandagal PB	2005	J Luminescence2005，12，1：	1
10	Bind ing of trazodone hydrochloride with human serum albumin A spectroscopic study显示文摘	Kandagal P B Seetharamappa J Shaikh S M T	2007	J Photochem Photobiol A2007，185，：	1
11	A study of the interaction between bromopyrogallol red and bovine serum albumin by spectroscopic methods显示文摘	SHAIKH S M T SEETHARAMAPPA J ASHOKA S	2007	Dyes and Pigments2007，73，2：	1
12	Study of the interaction of an anticancer drug with human and bovine serum albumin: spectroscopic approach 显示文摘	Kandagal P B Ashoka S Seetharamappa J	2006	J Pharm Bi omed Anal2006，41，2：	1
13	In vitro study on the interaction of mechanism of tricyclic compounds with bovine serum albumin显示文摘	KAMAT B P SEETHARAMAPPA J	2004	Journal of Pharmaceutical and Biomedical Analysis2004，35，：	1
14	Study of the interaction of an anticancer drug with human and bovine serum albumin:Spectroscopic approach显示文摘	Kandagal P B Ashoka S Seetharamappa J		0，，2：	1
15	Study of the interaction of an anticancer drug with human and bovine serum albumin: Spectroscopic approach 显示文摘	Kandagal PB Ashoka S Seetharamappa J	2006	J Pharm Biomed Anal2006，41，2：	1
16	Study of the interaction of an anticancer drug with human and bovine serum albumin:Spectroscopic approach显示文摘	Kandagal P B Ashoka S Seetharamappa J	2006	J Pharm Biomed Anal2006，41，：	1
17	In vitro study on the binding of anti-coagulant vitamin to bovine serum albumin and the influence of toxic ions and common ions on binding显示文摘	SHAIKH S M T SEETHARAMAPPA J KANDAGAL P B	2007	Int J Biol Macromol2007，41，1：	1
18	Study ofthe interaction of an anticancer drug with human and bo-vine serum albumin : Spectroscopic approach 显示文摘	Kandagal P B Ashoka S Seetharamappa J	2006	J PharmBiomed Anal2006，41，2：	1
19	Investigation of the interaction between trazodone hydrochloride and bovine serum albumin 显示文摘	Ashoka S Seetharamappa J Kandagal P B	2006	Journal of Luminescence( S0022-2313 )2006，121，1：	1
20	Characterization of interaction and the effect of carbamazepine on the structure of human serum albumin显示文摘	Shankara S. Kalanur J. Seetharamappa Veerendra Kumar A. Kalalbandi	2010	Journal of Pharmaceutical and Biomedical Analysis2010，，3：	1

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