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| 1 | Macrophage inhibitory cytokine-1/growth differentiation factor-15 in premalignant and neoplastic tumours in a high-risk pancreatic cancer cohort显示文摘BACKGROUND Pancreatic cancer(PC)is a leading cause of cancer related mortality worldwide,with poor survival due to late diagnosis.Currently,biomarkers have limited use in early diagnosis of PC.Macrophage inhibitory cytokine-1 or growth differentiation factor-15(MIC-1/GDF15)has been implicated as a potential serum biomarker in PC and other malignancies.AIM To determine the role of MIC-1/GDF15 in detecting pre-malignant pancreatic lesions and neoplastic tumours in an asymptomatic high-risk cohort part of Australian Pancreatic Cancer Screening Program.METHODS A feasibility prospective single centre cohort study was performed.Participants recruited for yearly surveillance with endoscopic ultrasound(EUS)had serial fasting blood samples collected before EUS for MIC-1/GDF15,C-reactive protein and carbohydrate antigen 19-9.Patients were stratified into five groups based on EUS findings:Normal;pancreatic cysts,branch-duct intraductal papillary mucinous neoplasm;diffuse non-specific abnormalities;and neoplastic tumours.MIC-1/GDF15 serum levels were quantified using ELISA.Participants in whom EUS demonstrated abnormalities but not malignancy were closely followed up with magnetic resonance imaging(MRI)or computed tomography.RESULTS One hundred twenty participants were prospectively recruited from 2011-2018.Forty-seven participants(39.2%)had an abnormal EUS and five participants(4.2%)were diagnosed with neoplastic tumours,three by EUS(two pancreatic and one liver)and two by MRI/computed tomography(breast cancer,bladder cancer),which were performed for follow up of abnormal EUS.Baseline serum MIC-1/GDF15 was a significant predictor of neoplastic tumours on receiver operator characteristic curve analysis[area under curve(AUC)=0.814,P=0.023].Baseline serum MIC-1/GDF15 had moderate predictive capacity for branch-duct intraductal papillary mucinous neoplasm(AUC=0.644)and neoplastic tumours noted on EUS(AUC=0.793),however this was not significant(P=0.188 and 0.081 respectively).Serial serum MIC-1/GDF15 did not demonstrate a significant percentage change between a normal and abnormal EUS(P=0.213).Median baseline MIC-1/GDF15 was greater in those with neoplastic tumours(Median=1039.6,interquartile range=727.0-1977.7)compared to those diagnosed with a benign lesion(Median=570.1,interquartile range=460.7-865.2)on EUS and MRI(P=0.012).CONCLUSION In this pilot study MIC-1/GDF15 has predictive capacity for neoplastic tumours in asymptomatic individuals with a genetic predisposition for PC.Further imagining may be warranted in patients with abnormal EUS and raised serum MIC-1/GDF15.Larger multicentric prospective studies are required to further define the role of MIC-1/GDF15 as a serological biomarker in pre-malignant pancreatic lesions and neoplastic tumours. | Robert Sean O’Neill Sam Emmanuel David Williams Alina Stoita | 2020 | World Journal of Gastroenterology2020，26，14： | 8 |
| 2 | 2019年全球二氧化碳排放量趋于稳定,预计2020年将下降显示文摘根据国际能源署(IEA)于2020年2月发布的一份报告[1],全球与能源相关的二氧化碳(CO2)排放量在2019年趋于稳定,为33Gt。这一稳定是在全球经济增长速度为2.9%的背景下发生的[2]。二氧化碳排放的明显停滞掩盖了由于地理、技术和商业波动而导致的排放量增加和减少的多样性。 | Sean O’Neill | 2020 | Engineering2020，6，9： | 4 |
| 3 | Conversion from prolonged intravenous fentanyl infusion to enteral methadone in critically ill children显示文摘AIM To describe our institutional experience with conversion from intravenous(IV) fentanyl infusion directly to enteral methadone and occurrence of withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation and analgesia.METHODS With Institutional Review Board approval,we retrospectively studied consecutively admitted invasively mechanically ventilated children(0-18 years) sedated with IV fentanyl infusion > 5 d and subsequently converted directly to enteral methadone.Data were obtained onsubject demographics,illness severity,daily IV fentanyl and enteral methadone dosing,time to complete conversion,withdrawal scores(WAT-1),pain scores,and need for rescue opioids.Patients were classified as rapid conversion group(RCG) if completely converted ≤ 48 h and slow conversion group(SCG) if completely converted in > 48 h.Primary outcome was difference in WAT-1 scores at 7 d.Secondary outcomes included differences in overall pain scores,and differences in daily rescue opioids.RESULTS Compared to SCG(n = 21),RCG(n = 21) had lower median WAT-1 scores at 7 d(2.5 vs 5,P = 0.027).Additionally,RCG had lower overall median pain scores(3 vs 6,P = 0.007),and required less median daily rescue opioids(3 vs 12,P = 0.003) than SCG.The starting daily median methadone dose was 2.3 times the daily median fentanyl dose in the RCG,compared to 1.1 times in the SCG(P = 0.049).CONCLUSION We observed wide variation in conversion from IV fentanyl infusion directly to enteral methadone and variability in withdrawal in critically ill mechanically ventilated children exposed to prolonged sedation.In those children who converted successfully from IV fentanyl infusion to enteral methadone within a period of 48 h,a methadone:fentanyl dose conversion ratio of approximately 2.5:1 was associated with less withdrawal and reduced need for rescue opioids. | Vijay Srinivasan Daniel Pung Sean P O'Neill | 2017 | World Journal of Clinical Pediatrics2017，6，2： | 3 |
| 4 | Ambulatory Arterial Stiffness Index as a Predictor of Cardiovascular Mortality in the Dublin Outcome Study显示文摘 | Eamon Dolan Lutgarde Thijs Yan Li Neil Atkins Patricia McCormack Sean McClory Eoin O’Brien Jan A. Staessen Alice V. Stanton | 2006 | Hypertension2006，，3： | 3 |
| 5 | Development of Lithium-Ion Batteries Wins Nobel Prize显示文摘We now live in a rechargeable world built on lithium(Li)-ion batteries(LIBs).In October 2019,three scientists/engineers who played pivotal roles in the development of LIB were each honoured with a one-third share of the Nobel Prize in Chemistry(Fig.1)[1].The LIB story began in the 1970s with M.Stanley Whittingham,now at Binghamton University,State University of New York,who discovered a hugely energy-rich material—titanium disulfide—that he used to create a novel cathode in a lithium battery.The battery,in which positively charged lithium ions moved back and forth between the electrodes during its charge/discharge cycle,had a potential of over two volts,but its anode contained highly reactive metallic lithium and therefore had a tendency to explode. | Sean O’Neill | 2020 | Engineering2020，6，5： | 2 |
| 6 | The CT-STAT (Coronary Computed Tomographic Angiography for Systematic Triage of Acute Chest Pain Patients to Treatment) Trial显示文摘 | James A. Goldstein Kavitha M. Chinnaiyan Aiden Abidov Stephan Achenbach Daniel S. Berman Sean W. Hayes Udo Hoffmann John R. Lesser Issam A. Mikati Brian J. O’Neil Leslee J. Shaw Michael Y.H. Shen Uma S. Valeti Gilbert L. Raff | 2011 | Journal of the American College of Cardiology2011，，14： | 1 |
| 7 | Walking Distances to and from Light-Rail Transit Stations显示文摘 | Sean O' Sullivan John Morrall | 1996 | Transportation Research Record: Journal of the Transportation Research Board1996，，1538： | 1 |
| 8 | Interstitial cells of cajal generate electrical slow wave in the murine stomach显示文摘 | Tamas O Sean MW Kenton MS | | 0，，： | 1 |
| 9 | Subband coding of images 显示文摘 | | 1986 | IEEE TRASACTIONS ON ACOUSTICS SPPECH AND SIGNAL PROCESSING1986，34，5： | 1 |
| 10 | Effect of an active packaging with citrus extract on lipid oxidation and sensory quality of cooked turkey meat显示文摘 | Claudia Contini Rocío álvarez Michael O’Sullivan Denis P. Dowling Sean óg Gargan Frank J. Monahan | 2014 | Meat Science2014，，3： | 1 |
| 11 | Examination of the photoinitiation processes in photopolymer materials显示文摘 | Michael R Gleeson Shui Liu Sean O’Duill | 2008 | J Appl Phys2008，104，： | 1 |
| 12 | The Medical Student Stress Profile:a tool for stress audit in medical training显示文摘 | Margaret O'Rourke Sean Hammond Siun O'Flynn | 2010 | Medical Education2010，，44： | 1 |
| 13 | Climate Change Action Alights on Satellite Detection of Methane显示文摘In an era of unwelcome broken records in climate change,2021delivered yet another.According to figures released in January2022 by the US National Oceanic and Atmospheric Administration(NOAA)[1,2],the record for the annual net increase in atmospheric methane was broken for the second year in a row,hitting an estimated 17 parts per billion(ppb).The increase puts methane’s atmospheric concentration at 1909 ppb(Fig.1),more than 2.5times its pre-industrial levels[3]. | Sean O’Neill | 2022 | Engineering2022，，9： | 1 |
| 14 | Synthesis of colloidal CuGaSe2, CuInSe2, and Cu(InGa)Se2 nanoparti- cles 显示文摘 | Tang Jiang Sean Hinds Shana O Kelley | 2008 | Chem Mater2008，20，22： | 1 |
| 15 | A Ka-band power amplifier based on the traveling-wave power-dividing/ combining slotted-waveguide circuit 显示文摘 | Jiang X Sean C O Amir M | 2004 | IEEE Trans MTT2004，52，2： | 1 |
| 16 | Center variation and outcomes associated with delayed sternal closure after stage 1 palliation for hypoplastic left heart syndrome显示文摘 | Jason N. Johnson James Jaggers Shuang Li Sean M. O’Brien Jennifer S. Li Jeffrey P. Jacobs Marshall L. Jacobs Karl F. Welke Eric D. Peterson Sara K. Pasquali | 2010 | The Journal of Thoracic and Cardiovascular Surgery2010，，5： | 1 |
| 17 | Walking distances to and from light-rail transit stations显示文摘 | Sean O'Sullivan John Morrall | 1996 | Transportation Research Record1996，，1583： | 1 |
| 18 | Integrating process and motor control显示文摘 | Timothy O' hearn John Somde Cerff Sean Miller | 2002 | Industry Applications Magazine IEEE2002，8，4： | 1 |
| 19 | Transformational Technology Takes Center Stage:Global Grand Challenges Summit 2019,Day One显示文摘With artificial intelligence(AI)systems now able to match the diagnostic abilities of seasoned doctors for certain ailments,and even suggest treatment options that no one had thought of,it is clear that AI and data science have the potential to transform aspects of healthcare for the better[1,2].Move beyond medicine,however,and things quickly get murkier:All over the world,the growing adoption of AI and other transformative technologies is raising countless societal,industrial,ethical,and environmental challenges. | Sean O’Neill | 2020 | Engineering2020，6，3： | 1 |
| 20 | Direct Air Carbon Capture Takes Baby Steps-Giant Strides Are Needed Sean O’Neill显示文摘In September 2021,the world’s largest industrial plant to pull carbon dioxide(CO_(2))directly out of the atmosphere officially became operational in Iceland.Designed and built by the Zurich,Switzerland-based company Climeworks,its“Orca”facility—the company claims—can remove and permanently store 4000 t of CO_(2) per year(Fig.1)[1]. | Sean O’Neill | 2022 | Engineering2022，8，1： | 1 |
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