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| 1 | Asthma and gastroesophageal reflux disease: Effect of long-term pantoprazole therapy显示文摘AIM: To define the prevalence of gastroesophageal reflux disease (GERD) in mild persistent asthma and to value the effect of pantoprazole therapy on asthmatic symptoms.METHODS: Seven of thirty-four asthmatic patients without GERD served as the non-GERD control group.Twenty-seven of thirty-four asthmatic patients had GERD (7/27 also had erosive esophagitis, sixteen of them presented GERD symptoms. An upper gastrointestinal endoscopy was performed in all the subjects to obtain five biopsy specimens from the lower 5 cm of the esophagus. Patients were considered to have GERD when they had a dilation of intercellular space (DIS)>0.74 μm at transmission electron microscopy.Patients with GERD were treated with pantoprazole,80 mg/day. Forced expiratory volume in one second (FEV1) was performed at entry and after 6 mo of treatment. Asthmatic symptoms were recorded. The required frequency of inhaling rapid acting 32-agonists was self-recorded in the patients' diaries.RESULTS: Seven symptomatic patients presented erosive esophagitis. Among the 18 asymptomatic patients, 11 presented DIS, while all symptomatic patients showed ultrastructural esophageal damage.Seven asymptomatic patients did not present DIS. At entry the mean of FEV1 was 1.91 L in symptomatic GERD patients and 1.88 L in asymptomatic GERD patients.After the treatment, 25 patients had a complete recovery of DIS and reflux symptoms. Twenty-three patients presented a regression of asthmatic symptoms with normalization of FEV1. Four patients reported a significant improvement of symptoms and their FEV1 was over 80%.CONCLUSION: GERD is a highly prevalent condition in asthma patients. Treatment with pantoprazole (80 mg/day)determines their improvement and complete regression. | Calabrese Carlo Fabbri Anna Areni Alessandra Scialpi Carlo Zahlane Desiree Di Febo Giulio | 2005 | World Journal of Gastroenterology2005，11，48： | 10 |
| 2 | Effect of omeprazole on symptoms and ultrastructural esophageal damage in acid bile reflux显示文摘AIM: To value whether omeprazole could induce the healing of DIS and regression of symptoms in patients with DGER.METHODS: We enrolled 15 symptomatic patients with a pathological esophageal 24-h pH-metry and bilimetry.Patients underwent endoscopy and biopsies were taken from the distal esophagus. Specimens were analyzed at histology and transmission electron microscopy (TEM).Patients were treated with omeprazole 40 mg/d for 3 mo and then endoscopy with biopsies was repeated. Patients with persistent heartburn and/or with an incomplete recovery of DIS were treated for 3 more months and endoscopy with biopsies was performed.RESULTS: Nine patients had a non-erosive reflux disease at endoscopy (NERD) while 6 had erosive esophagitis (ERD). At histology, of the 6 patients with erosive esophagus,5 had mild esophagitis and 1 moderate esophagitis. No patients with NERD showed histological signs of esophagitis.After 3 mo of therapy, 13/15 patients (86.7%, P<0.01)showed a complete recovery of DIS and disappearance of heartburn. Of the 2 patients treated for 3 more months,complete recovery of DIS and heartburn were achieved in one.CONCLUSION: Three or 6 mo of omeprazole therapy led to a complete regression of the ultrastructural esophageal damage in 86.7% and in 93% of patients with DGER, NERD and ERD respectively. The ultrastructural recovery of the epithelium was accompanied by regression of heartburn in all cases. | Carlo Calabrese Anna Fabbri Mauro Bortolotti Giovanna Cenacchi Scialpi Carlo Desiree Zahlane Mario Miglioli Giulio Di Febo | 2005 | World Journal of Gastroenterology2005，11，12： | 3 |
| 3 | Schwannoma of the rectum:A case report and literature review显示文摘Schwannoma is a tumor originating from the Schwann cells. Gastrointestinal schwannomas are uncommon stromal tumors of the intestinal tract and, in particular, rectal schwannomas are extremely rare. In fact, it is well established that schwannomas appear more frequently in the stomach and in the small intestine, while location in the colon or in the rectum is uncommon. Reading the literature, only few cases of rectal schwannoma have been reported. Their diagnosis is confirmed by the immunohisto chemical panel(S-100 protein). When these tumors are located in the colon and in the rectum, radical excision with wide margins is mandatory, due to their tendency to recur locally or become malignant, if left untreated. In the present study, we describe a case of a rectal schwannoma occured in a 72-year-old man, presented as a small polypoid lesion, which was successfully removed in toto by hot-biopsy, during the same endoscopy, due to the dimensons. No recurrence of the lesion was observed after 6 mo of follow-up. | Maddalena Zippi Roberta Pica Renzo Scialpi Claudio Cassieri Eleonora Veronica Avallone Giuseppe Occhigrossi | 2013 | World Journal of Clinical Cases2013，1，1： | 2 |
| 4 | Influence of shoulder geometry on microstructure and mechanical properties of friction stir welded 6082 aluminium alloy显示文摘 | A. Scialpi L.A.C. De Filippis P. Cavaliere | 2006 | Materials and Design2006，，4： | 2 |
| 5 | Three–dimensional analysis of pulmonary nodules by MSCT with Advanced Lung Analysis (ALA1) software显示文摘 | L. Volterrani M. A. Mazzei M. Scialpi M. Carcano S. F. Carbone V. Ricci G. Guazzi L. Lupattelli | 2006 | La radiologia medica2006，，3： | 1 |
| 6 | AIDS-related lymphoma: US and CT in thoracic and abdominal manifestations显示文摘 | Scialpi M Magli T Scialpi P | 1994 | Rays1994，19，2： | 1 |
| 7 | Blunt trauma to the gastrointestinal tract and mesentery :is there a role for helical CT in the decision-making process显示文摘 | Scaglione M de Lutio di castelguidone E Scialpi M | 2004 | Eur J Radiol2004，50，1： | 1 |
| 8 | Flexural reinforcement of glulam timber beams and joints with carbon fiberreinforced polymer rods 显示文摘 | Micelli F Scialpi V Tegola A | 2005 | Journal of Composites for Construction2005，4，9： | 1 |
| 9 | Focal nodular hyperplasia in normal and fatty liver:a qualitative and quantitative evaluation with contrast-enhanced ultrasound显示文摘 | Bartolotta TV Midiri M Scialpi M | 2004 | Eur Radiol2004，4，4： | 1 |
| 10 | Analytical and experimental study on bonded-in CFRP bars in glulam wood 显示文摘 | De Lorenzis L Scialpi V La Tegola A | 2005 | Composite P art B: Engineering2005，36，： | 1 |
| 11 | Analytical and experimental study on bonded-in CFRP bars in glulam timber显示文摘 | LORENZIS L D SCIALPI V TEGOLA A L | 2005 | J Compos Part (B)2005，36，4： | 1 |
| 12 | Focal nodular hyperplasia in normal and fatty liver:a qualitative and quantitative evaluation with contrast-enhanced ultrasound显示文摘 | Bartolotta T V Midiri M Scialpi M | 2004 | Eur Radiol2004，14，4： | 1 |
| 13 | Influence of shou- lder geometry on microstructure and mechanical properties of friction stir welded 6082 aluminium alloy显示文摘 | Scialpi A De Filippis L A C Cavaliere P | 2007 | Materials and Design2007，28，4： | 1 |
| 14 | Analytical and experimental study on bonded-in CFRP bars in glulam timber显示文摘 | LORENZIS L D SCIALPI V TEGOLA A L | 2005 | Composites part B : engineering2005，36，4： | 1 |
| 15 | Diagnosis and endovascular treatment of an internal mammary artery injury显示文摘 | Cagini L Vannucci J Scialpi M | 2013 | J Emerg Med2013，44，1： | 1 |
| 16 | Analytical and experimental study on bonded-in CFRP bars in glulam wood 显示文摘 | De Lorenzis L Scialpi V La Tegola A | 2005 | Composite Part B : Engineering2005，36，4： | 1 |
| 17 | Analytical and experimental study on bonded-in CFRP bars in glulam timber 显示文摘 | De Lorenzis Laura Scialpi Vincenza La Tegola An- tonio | 2005 | Composites Part B: Engineering2005，36，4： | 1 |
| 18 | Flexural reinforcement of glulam timber beams and joints with carbon fiber-reinforced polymer rods 显示文摘 | Micelli Francesco Scialpi Vincenza La Tegola An- tonio | 2005 | Journal of Composites for Construction2005，9，4： | 1 |
| 19 | Itch self-polyu- biquitylation occurs through lysine-63 linkages显示文摘 | Scialpi F Malatesta M Peschiaroli A | 2008 | Biochem Pharmacol2008，76，： | 1 |
| 20 | Blunt trauma to the gastrointestinal tract and mesentery~ is there a role for helical CT in the decision-making process? 显示文摘 | Scaglione M Castelguidone E Scialpi M | 2004 | Eur J Radiol2004，50，1： | 1 |
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