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| 1 | The role of gut microbiota(commensal bacteria)and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer:contribution of germ-free and gnotobiotic animal models of human diseases显示文摘Metagenomic approaches are currently being used to decipher the genome of the microbiota(microbiome),and,in parallel,functional studies are being performed to analyze the effects of the microbiota on the host.Gnotobiological methods are an indispensable tool for studying the consequences of bacterial colonization.Animals used as models of human diseases can be maintained in sterile conditions(isolators used for germ-free rearing)and specifically colonized with defined microbes(including non-cultivable commensal bacteria).The effects of the germ-free state or the effects of colonization on disease initiation and maintenance can be observed in these models.Using this approach we demonstrated direct involvement of components of the microbiota in chronic intestinal inflammation and development of colonic neoplasia(i.e.,using models of human inflammatory bowel disease and colorectal carcinoma).In contrast,a protective effect of microbiota colonization was demonstrated for the development of autoimmune diabetes in non-obese diabetic(NOD)mice.Interestingly,the development of atherosclerosis in germ-free apolipoprotein E(ApoE)-deficient mice fed by a standard low-cholesterol diet is accelerated compared with conventionally reared animals.Mucosal induction of tolerance to allergen Bet v1 was not influenced by the presence or absence of microbiota.Identification of components of the microbiota and elucidation of the molecular mechanisms of their action in inducing pathological changes or exerting beneficial,disease-protective activities could aid in our ability to influence the composition of the microbiota and to find bacterial strains and components(e.g.,probiotics and prebiotics)whose administration may aid in disease prevention and treatment. | Helena Tlaskalova-Hogenova Renata Stepankova Hana Kozakova Tomas Hudcovic Luca Vannucci Ludmila Tuckova Pavel Rossmann TomasHrncır Miloslav Kverka Zuzana Zakostelska Klara Klimesova Jaroslava Pribylova Jirina Bartova Daniel Sanchez Petra Fundova Dana Borovska Dagmar Sru˚tkova Zdenek Zıdek Martin Schwarzer Pavel Drastich David P Funda | 2011 | Cellular & Molecular Immunology2011，8，2： | 47 |
| 2 | Biological reaction to vibration implications for sport显示文摘 | MESTER J SPITZENFEIL P SCHWARZER J | 1999 | Sci Med Sport1999，，： | 1 |
| 3 | The assessment of optimistic self-beliefs:comparison of the German,Spanish,and Chinese versions of the general self-efficacy sCale显示文摘 | Schwarzer R Bassler J Kwiatek P | 1997 | Applied Psychology-an International Review-Psyehologie Appliquee-Revue Intemationale1997，46，1： | 1 |
| 4 | The assessment of optimistic self beliefs:Comparison of the german,spanish,and chinese version of the general self-efficacy scale显示文摘 | SCHWARZER R KWIATEK P SCHRDERK | 1997 | Applied Psychology:An International Review1997，46，1： | 1 |
| 5 | The Assessment of Optimistic Self-Beliefs: Comparison of the Ger man, Spanish, and Chinese Version of the Gennel Self-Efficacy Scale 显示文摘 | SCHWARZER R BABLER J KWIATCK P | 1997 | Applied Psychology: An International Review1997，46，1： | 1 |
| 6 | The assessment of optimistic self - beliefs: comparison of the german, spanish, and chinese versions of the general self - efficacy scale 显示文摘 | Schwarzer R Bassler J Kwiatek P | 1997 | Applied Psychology1997，46，1： | 1 |
| 7 | The assessment of optimistic self-beliefs: comparison of the German, Spanish, and Chinese version of the general self-efficacy scale 显示文摘 | Schwarzer R Babler J Kwiatek P | 1997 | Psychol Rep1997，46，1： | 1 |
| 8 | Prognostic value and clinical effectiveness of high sensitivity C-reactive protein as a marker in primary preventionof major cardiac events显示文摘 | Schwarzer R Schnell-Inderst P Grabein K | 2009 | Z Evid Forthild Qual Gesundhwes2009，103，6： | 1 |
| 9 | The Assessment of optimistic self-beliefs:comparison of the German,Spanish,and Chinese versions of the General Self-emcacy Scale显示文摘 | Schwarzer R Baβler J Kwiatek P | 1997 | Applied Psychology:An International Review1997，46，1： | 1 |
| 10 | ^1H-NMR relaxation study of cross-linking and aging processes in polyurethane coatings 显示文摘 | Fratricova M Schwarzer P Kuhn W | 2006 | Kantschuk und Gummi Kunststoffe2006，5，： | 1 |
| 11 | Treatment of ocular hypertension and open angle glaucoma:Meta-analysis of randomised controlled trials显示文摘 | Maier P C Funk J Schwarzer G | 2005 | BMJ2005，331，7509： | 1 |
| 12 | Prognostic value and clinical effectiveness of high sensitivity C-reactive protein as a marker in primary prevention of major cardiac events显示文摘 | Schwarzer R Schnell-Inderst P Grabein K | 2009 | Z Evid Fortbild Qual Gesundhwes2009，103，6： | 1 |
| 13 | Prognostic valueand clinical effectiveness of high sensitivity C-reactive protein as amarker in primary prevention of majior cardiac events显示文摘 | Schwarzer R Schnell-Inderst P Grabein K | 2009 | Z EvidFortbild Qual Gesundhwes2009，103，6： | 1 |
| 14 | The assessment of optimistic self-be- liefs : Comparison fo the German, Spanish, and Chinese version of the general self-efficacy scale 显示文摘 | Schwarzer R Babler J Kwiatek P Schroder K Jianxin Z H | 1997 | Applied Psychology : An International Re- view1997，46，1： | 1 |
| 15 | The assessment of optimistic self-beliefs:Comparison of the German,Spanish,and Chinese version of the General Self-Efficacy scale显示文摘 | Schwarzer R Kwiatek P Bassler J | | 0，，： | 1 |
| 16 | Band 3/complement-mediated recognition and removal of normally senescent and pathological human erythrocytes显示文摘 | Arese P Turrini F Schwarzer E | 2005 | Cell Physiol Bioehem2005，16，46： | 1 |
| 17 | Prognostic value and clinical effectiveness of high sensitivity C-reactive protein as a marker in primary prevention of major cardiac events显示文摘 | SCHWARZER R SCHNELL INDERST P GRABEIN K | 2009 | Z Evid Fortbild Qual Gesundhwes2009，103，6： | 1 |
| 18 | Recombinant human erythropoiesis-stimulating agents and mortality in patients with cancer: a meta-analysis of randomised trials显示文摘 | Julia Bohlius Kurt Schmidlin Corinne Brillant Guido Schwarzer Sven Trelle Jerome Seidenfeld Marcel Zwahlen Michael Clarke Olaf Weingart Sabine Kluge Margaret Piper Dirk Rades David P Steensma Benjamin Djulbegovic Martin F Fey Isabelle Ray-Coquard Mitchell | 2009 | The Lancet2009，，9674： | 1 |
| 19 | The Assessment of Optimistic Self Beliefs:Comparison of the German,Spanish,and Chinese Version of the General Self-Efficacy Scale显示文摘 | SCHWARZER R KWIATEK P SCHRODER K | | 0，，： | 1 |
| 20 | Prognostic value, clinical effectiveness,and cost effectiveness of high sensitiv- ity C- reactive protein as a marker for major cardiac events in asymptomatic individuals: A health technology assessment report显示文摘 | Schnell - Inderst P Schwarzer R Gohler A | 2010 | Int J Technol Assess Health Care2010，26，1： | 1 |
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