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| 1 | Biliary complications following liver transplantation: Singlecenter experience over three decades and recent risk factors显示文摘AIM To identify independent risk factors for biliary complications in a center with three decades of experience in liver transplantation.METHODS A total of 1607 consecutive liver transplantations were analyzed in a retrospective study. Detailed subset analysis was performed in 417 patients, which have been transplanted since the introduction of Model of End-Stage Liver Disease(MELD)-based liver allocation. Risk factors for the onset of anastomotic biliary complications were identified with multivariable binary logisticregression analyses. The identified risk factors in regression analyses were compiled into a prognostic model. The applicability was evaluated with receiver operating characteristic curve analyses. Furthermore, Kaplan-Meier analyses with the log rank test were applied where appropriate. RESULTS Biliary complications were observed in 227 cases(14.1%). Four hundred and seventeen(26%) transplantations were performed after the introduction of MELD-based donor organ allocation. Since then, 21%(n = 89) of the patients suffered from biliary complications, which are further categorized into anastomotic bile leaks [46%(n = 41)], anastomotic strictures [25%(n = 22)], cholangitis [8%(n = 7)] and non-anastomotic strictures [3%(n = 3)]. The remaining 18%(n = 16) were not further classified. After adjustment for all univariably significant variables, the recipient MELD-score at transplantation(P = 0.006; OR = 1.035; 95%CI: 1.010-1.060), the development of hepatic artery thrombosis post-operatively(P = 0.019; OR = 3.543; 95%CI: 1.233-10.178), as well as the donor creatinine prior to explantation(P = 0.010; OR = 1.003; 95%CI: 1.001-1.006) were revealed as independent risk factors for biliary complications. The compilation of these identified risk factors into a prognostic model was shown to have good prognostic abilities in the investigated cohort with an area under the receiver operating curve of 0.702.CONCLUSION The parallel occurrence of high recipient MELD and impaired donor kidney function should be avoided. Risk is especially increased when post-transplant hepatic artery thrombosis occurs. | Alexander Kaltenborn André Gutcke Jill Gwiasda Jürgen Klempnauer Harald Schrem | 2017 | World Journal of Hepatology2017，9，3： | 6 |
| 2 | Decision modelling for economic evaluation of liver transplantation显示文摘As the gap between a shortage of organs and the immense demand for liver grafts persists, every available donor liver needs to be optimized for utility, urgency and equity. To overcome this challenge, decision modelling might allow us to gather evidence from previous studies as well as compare the costs and consequences of alternative options. For public health policy and clinical intervention assessment, it is a potentially powerful tool. The most commonly used types of decision analytical models include decision trees, the Markov model, microsimulation, discrete event simulation and the system dynamic model. Analytic models could support decision makers in the field of liver transplantation when facing specific problems by synthesizing evidence, comprising all relevant options, generalizing results to other contexts, extending the time horizon and exploring the uncertainty. For modeling studies of economic evaluation for transplantation, understanding the current nature of the disease is crucial, as well as the selection of appropriate modelling techniques. The quality and availability of data is another key element for the selection and development of decision analytical models. In addition, good practice guidelines should be complied, which is important for standardization and comparability between economic outputs. | Zhi Qu Christian Krauth Volker Eric Amelung Alexander Kaltenborn Jill Gwiasda Lena Harries Jan Beneke Harald Schrem Sebastian Liersch | 2018 | World Journal of Hepatology2018，10，11： | 6 |
| 3 | Review: Surgical Shunts and Encephalopathy显示文摘 | Jürgen Klempnauer Harald Schrem | 2001 | Metabolic Brain Disease (-)2001，，1： | 2 |
| 4 | Surgical shunts and encephalopathy显示文摘 | Klempnaue J Schrem H | 2001 | Metab Brain Dis2001，16，12： | 1 |
| 5 | Extended right liver grafts obtained by an ex situ split can be used safely for primary and secondary transplantation with acceptable biliary morbidity显示文摘 | Takebe A Schrem H Ringe B | | 0，，07： | 1 |
| 6 | Surgical treatment and outcome of iatrogenic bile duct lesions after cholecystectomy and the impact of different clinical classification systems显示文摘 | Bektas H Schrem H Winny M | 2007 | Brit J Surg2007，94，： | 1 |
| 7 | Methodology for an energy and resource efficient process chain design显示文摘 | SCHREMS S EISELE C ABELE E | 2011 | Glocalized Solutions for Sustainability in Manufacturing2011，17，3： | 1 |
| 8 | Physiological incompatibilities of porcine hepatocytes for clinical liver support显示文摘 | SCHREM H KLEINE M BORLAK J | 2006 | Liver Transpl2006，12，： | 1 |
| 9 | Energy-Efficient Machine Tools through Simulation in the Design Process显示文摘 | EISELE C SCHREMS S ABELE E | 2011 | Glocalized Solutions for Sustainability in Manufacturing2011，5，： | 1 |
| 10 | Collapse of the blood-aqueous humor barrier following laser injury-preventive pharmacotherapy with prostaglandin inhibitors显示文摘 | Schrems W | | 0，，： | 1 |
| 11 | Oxygen in acute and chronic wound healing显示文摘 | Schrem| S Szeimies RM Prantl L | 2010 | Br J Dermatol2010，163，2： | 1 |
| 12 | Determination of tropical cirrus properties by simultaneous lidar and radiosonde measurements 显示文摘 | Franz Immler Otto Schrems | 2002 | Geophys Res Lett2002，29，23： | 1 |
| 13 | Wear Mechanisms in a Nonrotating Wire Rope显示文摘 | Schrems K K Dogan C R Hawk J A | 1995 | Journal of Materials Engineering and Performanee1995，4，2： | 1 |
| 14 | Energy- efficient machine tools through simulation in the design process 显示文摘 | Esisele C Schrems S Abelb E | 2011 | Glocalized Solutions for Sustain- ability in Manufacturing2011，，5： | 1 |
| 15 | H2 02 in the marine troposphere and sea- water of the Atlantic Ocean ( 48 o N-63 o S ) 显示文摘 | Weller R Schrems O | 1993 | Geophysical Re- search Letters1993，20，2： | 1 |
| 16 | Extended surgery for advanced pancreatic endocrine tumours显示文摘 | Kleine M Schrem H Vondran FW | 2012 | Br J Surg2012，99，1： | 1 |
| 17 | Variability of formaldehydein the Antarctic troposphere 显示文摘 | RIEDEL K WELLER R SCHREMS 0 | 1999 | Physical Chemistry ChemicalPhysics1999，1，24： | 1 |
| 18 | a-Glutathione-S-trans-ferase is a sensitive marker of hepatocellular damage due to warm or cold ischemia in pig liver transplantation显示文摘 | Schon MR Akkoc N Schrem H | 1997 | Transplant Proc1997，29，： | 1 |
| 19 | Liver transplantation today 显示文摘 | Klempnauer J Schrem H Becker T | 2001 | Transplant Proc2001，33，78： | 1 |
| 20 | The immediate IOP response of Nd-YAG-laser iridotomy and its prophylactic treatability显示文摘 | Schrems W Eichelbronner O Krieglstein GK | 2004 | Acta Ophthalmol2004，62，5： | 1 |
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