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| 1 | Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea. | Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal | 2005 | World Journal of Gastroenterology2005，11，39： | 26 |
| 2 | Suppression of apoptosis in the protein kinase Cdelta null mouse in vivo显示文摘 | Humphries M J Limesand K H Schneider J C | 2006 | J Biol Chem2006，281，14： | 1 |
| 3 | Aging of non-ceramic insulators due to corona from water drops显示文摘 | Phillips J Childs D J Schneider H M | 1999 | IEEE Transactions on Power Delivery1999，14，3： | 1 |
| 4 | Porphyrin-based Peptide Receptors: Syntheses and NMR Analysis 显示文摘 | Sirish M Chertkov V A Schneider H J | 2002 | Chemistry2002，8，5： | 1 |
| 5 | The atmospheric input of trace species to the world ocean显示文摘 | Duce R A Liss P S Merrill J T Atlas L L Buat-Menard P Hicks B B Miller J M Prospero J M Arimoto R Church T M Ellis W Galloway F N Hansen L Jickells T D Knap A H Reinhardt K H Schneider B Soudine A Tokos J J Tsunogai S Wollast R Zhou M | 1991 | Global Biogeochemical Cycles1991，5，： | 1 |
| 6 | Phylogeny,classification and floral evolution of water lilies (Nymphaeaceae,Nymphaeales):A synthesis of non-molecular,rbcL,matK,and 18S rDNA data显示文摘 | Les D H Schneider E L Padgett D J Soltis P S Soltis D E Zanis M | 1999 | Systematic Botany1999，24，1： | 1 |
| 7 | Aging of nonceramic insulators due to corona from water drops 显示文摘 | PHILIPS J CHILDS D J SCHNEIDER H M | 1999 | IEEE Transactions on Power Delivery1999，14，3： | 1 |
| 8 | Accelerated ageing and flashover tests on 138kV nonceramic insulators显示文摘 | Schneider H M Guidi W W Bmnham J T | 1993 | IEEE Transactions on Power Delivery1993，8，1： | 1 |
| 9 | Phylogenetic relationships in the Lejeuneaceae (Hepaticae) inferred using ITS sequences of nuclear ribosomal DNA 显示文摘 | Groth-Malonek M Heinrichs J Schneider H | 2004 | Organism Diversity and Evolution2004，4，： | 1 |
| 10 | Water drop corona effects on full-scale 500 kV non-ceramic insulators 显示文摘 | PHILIPS J CHILDS D J SCHNEIDER H M | 1999 | IEEE Transactions on Power Delivery1999，14，1： | 1 |
| 11 | 1, 2, 8-Trihydroxyoctahydro indo lizine (swainsonine), anα-mannosidase inhibitor from Rhizoctonia legumincola 显示文摘 | Schneider M J Ungemach F S Broquist H P | 1983 | Tetrahedron1983，39，： | 1 |
| 12 | Surface resistance measurements on nonceramic insulators显示文摘 | Gorur R S Schneider H M Cartwright J | 2001 | IEEE Trans on Power Delivery2001，16，4： | 1 |
| 13 | Elevation of serum and urine levels of TIMP-1 and tenascin in patients with renal diseas显示文摘 | Horstrup J H Gehrmann M Schneider B | 2002 | Nephrol Dial Transplant2002，17，6： | 1 |
| 14 | Aging of non-ceramic insulators due to corona from water drops显示文摘 | Phillips J Childs D J Schneider H M | 1999 | IEEE Transactions on Power Delivery1999，14，3： | 1 |
| 15 | Agmg of non-ceramic insulators due to corona fkom water drops 显示文摘 | PHILLIPS A J CHILDS D J SCHNEIDER H M | 1999 | IEEE Transaction Power Delivery1999，14，3： | 1 |
| 16 | Non-destructive evaluation of diamond-like carbon films by laser induced surface acoustic waves显示文摘 | D Schneider T Schwarz H J Scheibe M Panzner | 1997 | Thin Solid Films1997，295，： | 1 |
| 17 | Selection of functional human antibodies from retroviral display libraries 显示文摘 | URBAN J H SCHNEIDER R M COMPTE M | 2005 | Nucleic Acids Res2005，33，4： | 1 |
| 18 | 早期将抗生素由静脉转为口服治疗严重社区获得性肺炎:多中心随机试验显示文摘目的比较早期由静脉转换成口服抗生素与常规静脉使用7天抗生素治疗严重社区获得性肺炎(CAP)的疗效。设计多中心随机对照试验。地点荷兰5家教学医院和2所大学的医学中心。参加者非 ICU 住院的严重 CAP 患者302例,其中265例满足研究要求。干预静脉抗生素治疗3天,病情稳定后换成口服抗生素,或静脉使用抗生素治疗7天。主要评价结果临床治愈和住院天数。结果 302例患者被随机分组(平均年龄69.5岁,标准差14.0),肺炎严重度评分平均112.7(26.0)。37例患者因为提前3天退出而未纳入分析,对其余265例患者进行分析研究。第28天的死亡率在干预组是4%,对照组是6%(平均差2%,95%可信区间-3%~8%)。临床治愈率在干预组是83%,对照组是85%(2%;-7%~10%)。与对照组相比,干预组患者静脉治疗时间为3.4天[3.6(1.5)比7.0(2.0)天;2.8~3.9],患者住院天数减少1.9天[9.6(5.0)比11.5(4.9)天;0.6~3.2]。结论早期将抗生素由静脉应用转换成口服治疗严重 CAP 是安全的,并且可以减少住院时间2天。试验注册号临床试验 NCT00273676。 | Jan Jelrik Oosterheert Marc J M Bonten Margriet M E Schneider Erik Buskens Jan-Willem J Lammers Willem M N Hustinx Mark H H Kramer Jan M Prins Peter H Th J Slee Karin Kaasjager Andy I M Hoepelman 王伟巍(译) 童朝辉(校) | 2007 | 英国医学杂志中文版2007，10，2： | 1 |
| 19 | Calcium signaling by HBx protein in hepatitis B virus DNA replication显示文摘 | Bouchard M J Wang L H Schneider R J | | 0，，5550： | 1 |
| 20 | RNase of classical swine fever virus:biochemical characterization and inhibition by virus-neutralizing mono- clonal antihodies显示文摘 | Windiseh J M Schneider R Stark R Weiland E Meyers G Thiel H J | 1996 | J Virol1996，70，1： | 1 |
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