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| 1 | Transient micro-elastography:A novel non-invasive approach to measure liver stiffness in mice显示文摘AIM:To develop and validate a transient micro-elastography device to measure liver stiffness(LS) in mice.METHODS:A novel transient micro-elastography(TME) device,dedicated to LS measurements in mice with a range of measurement from 1-170 kPa,was developed using an optimized vibration frequency of 300 Hz and a 2 mm piston.The novel probe was validated in a classical fibrosis model(CCl4) and in a transgenic murine model of systemic amyloidosis.RESULTS:TME could be successfully performed in control mice below the xiphoid cartilage,with a mean LS of 4.4 ± 1.3 kPa,a mean success rate of 88%,and an excellent intra-observer agreement(0.98).Treatment with CCl4 over seven weeks drastically increased LS as compared to controls(18.2 ± 3.7 kPa vs 3.6 ± 1.2 kPa).Moreover,fibrosis stage was highly correlated with LS(Spearman coefficient = 0.88,P < 0.01).In the amyloidosis model,much higher LS values were obtained,reaching maximum values of > 150 kPa.LS significantly correlated with the amyloidosis index(0.93,P < 0.0001) and the plasma concentration of mutant hapoA-□(0.62,P < 0.005).CONCLUSION:Here,we have established the first non-invasive approach to measure LS in mice,and have successfully validated it in two murine models of high LS. | Cécile Bastard Matteo R Bosisio Michèle Chabert Athina D Kalopissis Meriem Mahrouf-Yorgov Hélène Gilgenkrantz Sebastian Mueller Laurent Sandrin | 2011 | World Journal of Gastroenterology2011，17，8： | 4 |
| 2 | 9种商业消毒剂对猪2型圆环病毒的杀灭效能测试显示文摘养猪业中常用的许多商业消毒剂,都获得了法国农业部批准。然而对其杀灭增殖初期猪2型圆环病毒(PCV2)的效能却不甚了解。用在法国分离到的PCV2悬液来测试9种商业消毒剂的效能,在20℃下病毒悬液与消毒剂作用30 min后,将该混合液过滤和稀释进行脱毒处理以去除对圆环病毒和猪肾细胞系有害的物质,再经一系列稀释后接种于人工培养的猪肾细胞进行免疫过氧化物酶单层细胞试验(IPMA)测定PCV2的感染性。结果表明,用碘类和苯酚类消毒剂并不能减少病毒滴度。在此着重介绍其他消毒剂效能(病毒滴度减少量≥1.61 log_(10)),其中5种消毒剂:一种含过一硫酸氢钾,另两种含一种季铵盐、一到三种醛、次氯酸钠和氢氧化钠,在标准浓度下或1.5~4倍低于标准浓度时可显著杀灭PCV2;其余两种,其中一种含过一硫酸氢钾,另一种含过氧乙酸和过氧化氢,在标准浓度下或2倍高于标准浓度时也可杀灭PCV2。 | Hélène Martin Marie-Frédérique Le Potier Pierre Maris 杨满军 | 2009 | 今日养猪业2009，，3： | 2 |
| 3 | 胚胎巨噬细胞和小胶质细胞消融调控小鼠胚胎背根神经节感觉神经元的发育显示文摘众所周知,小胶质细胞可以调节中枢神经系统发育的一些方面。在第11.5天的小鼠胚胎中的小胶质细胞定殖脊髓时,它们与背根神经节感觉神经元(SN)的生长中心轴突相互作用,这表明它们可能在SN发育中发挥一定功能。为了解决这个问题,我们使用缺乏胚胎巨噬细胞(PU.1敲除小鼠)和免疫细胞消融的小鼠胚胎分析胚胎巨噬细胞消融对SNs早期发育的影响。我们发现,除小胶质细胞外,胚胎巨噬细胞还与来自第11.5天的小鼠胚胎的原肌球蛋白受体激酶(Trk)C+感觉神经元,TrkB+感觉神经元和TrkA+感觉神经元外周神经突产生交联。免疫细胞剥夺会导致第11.5天的小鼠胚胎的TrkC+感觉神经元和TrkB+感觉神经元初始数量的减少,这与其发育细胞死亡(DCD)的改变有关联的可能性较小,因为其后在第12.5天的胚胎中的数量有短暂增加。在分析的发育期(第11.5~15.5天),它也导致TrkA+感觉神经元数量减少,尽管我们没有观察到他们的DCD有任何变化。与神经元祖细胞可能存在一致性的脑脂肪酸结合蛋白(BFABP-)阴性细胞的增殖在第11.5天的胚胎中增加,而它们的增殖在第12.5天的胚胎减少,这可部分解释从11.5 d观察到的SN亚型产生的改变。此外,我们观察到在缺乏胚胎巨噬细胞的情况下神经胶质细胞祖细胞(BFABP+细胞)增殖的改变。我们的数据表明,胚胎巨噬细胞和小胶质细胞消融调控SN的发育。 | Angelim MKSC Maia LMSS Mouffle C Ginhoux F Low D Amancio-Dos-Santos A Makhoul J Le Corronc H Mangin JM Legendre P 聂昊(编译) | 2018 | 神经损伤与功能重建2018，13，9： | 2 |
| 4 | Analysis of translation elongation factors from wheat during development and following heat shock显示文摘 | Gallic D R Le H Caldwell C Browning K S | 1998 | Biochemical and Biophysical Research Communications1998，245，： | 1 |
| 5 | A long reset-time power-on re- set circuit with brown-out detection capability 显示文摘 | Le H B Do X D Lee S G | 2011 | Circuits and Systems II: Express Briefs IEEE Transactions on2011，58，： | 1 |
| 6 | Efficient 3D modelling of vibration isolation by open trenches显示文摘 | Klein R Antes H Le Houedec D | 1997 | Computers and Structures1997，64，1： | 1 |
| 7 | Modeling the impact of summer temperatures on national electricity consumption显示文摘 | Le Comte D M Warren H E | 1981 | J Appl Meteor1981，20，12： | 1 |
| 8 | RNA-interference therapy for HBV infection enters phase I clinical trial显示文摘 | Le D H | 2008 | Expert Review of Anti-Infective Therapy2008，6，1： | 1 |
| 9 | Relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour 显示文摘 | Anselme K Linez P Bigerelle M Le Maguer D Le Maguer A Hardouin P Hildebrand H F Iost A Leroy J M | 2000 | Biomaterials2000，21，： | 1 |
| 10 | Stewardship or agency? A social embeddedness reconciliation of conduct and performance in public family businesses显示文摘 | Le Breton-Miller I Miller D Lester R H | 2011 | Organization Science2011，22，3： | 1 |
| 11 | The liquid-phase reaction of hexane on acid mordenite显示文摘 | Facasiu D Le K H | 2001 | Catal Commun2001，2，1： | 1 |
| 12 | Influence of host and non-host plant pollen on the calling and oviposition behaviour of the sunflower moth Homoeosoma nebulellure (Lepidoptera:Pyralidae)显示文摘 | Metayer M Le Pham-Delegue M H Thiery D | 1993 | Ecologica1993，14，5： | 1 |
| 13 | Epidermal growth factor receptor mutation in lung cancer are linked to bronchioloalveolar differentiation显示文摘 | Blons H Cote J F Le Corre D | 2006 | Am J Surg Pathol2006，30，10： | 1 |
| 14 | Introducing two indicators for fire risk consideration in the management of boreal forests显示文摘 | Frédéric Raulier Hélo?se Le Goff Sylvie Gauthier Rija Rapanoela Yves Bergeron | 2013 | Ecological Indicators2013，，： | 1 |
| 15 | Histone lysine demethylase JARIDlaactivates CLOCK-]3MAL1 and influences the circadian clock显示文摘 | Ditacchio L Le H D Vollmers C | 2011 | Science2011，333，： | 1 |
| 16 | Automated Page Orientation and Skew Angle Detection for Binary Document Images显示文摘 | Le D S Thoma G R Wechsler H | 1997 | Pattern Recognition1997，27，10： | 1 |
| 17 | Protective role of heme oxygenase - 1 in oxidative stress - induced neuronal injury 显示文摘 | LE W D XIE W J APPEL S H | 1999 | J Neurosci Res1999，56，6： | 1 |
| 18 | The major genetic determinants of HIV-1control affect HLA class I peptide presentation显示文摘 | International HIV Controllers Study Pereyra F Jia X McLaren P J Telenti A de Bakker P I Walker B D Ripke S Brumme C J Pulit S L Carrington M Kadie C M Carlson J M Heckerman D Graham R R Plenge R M Deeks S G Gianniny L Crawford G Sullivan J Gonzalez E Davies L Camargo A Moore JM Beattie N Gupta S Crenshaw A Burtt N P Guiducci C Gupta N Gao X Qi Y Yuki Y Piechocka-Trocha A Cutrell E Rosenberg R Moss K L Lemay P O'Leary J Schaefer T Verma P Toth I Block B Baker B Rothchild A Lian J Proudfoot J Alvino D M Vine S Addo M M Allen T M Altfeld M Henn M R Le Gall S Streeck H Haas D W Kuritzkes D R Robbins G K Shafer R W Gulick R M Shikuma C M Haubrich R Riddler S Sax P E Daar E S Ribaudo H J Agan B Agarwal S Ahern R L Allen B L Altidor S Altschuler E L Ambardar S Anastos K Anderson B Anderson V Andrady U Antoniskis D Bangsberg D Barbaro D Barrie W Bartczak J Barton S Basden P Basgoz N Bazner S Bellos N C Benson A M Berger J Bernard N F Bernard A M Birch C Bodner S J Bolan R K Boudreaux E T Bradley M Braun J F Brndjar J E Brown S J Brown K Brown S T Burack J Bush LM Cafaro V Campbell O Campbell J Carlson R H Carmichael J K Casey K K Cavacuiti C Celestin G Chambers S T Chez N Chirch L M Cimoch P J Cohen D Cohn LE Conway B Cooper D A Cornelson B Cox D T Cristofano M V Cuchural G Jr Czartoski J L Dahman J M Daly J S Davis B T Davis K Davod S M DeJesus E Dietz C A Dunham E Dunn M E Ellerin T B Eron J J Fangman J J Farel C E Ferlazzo H Fidler S Fleenor-Ford A Frankel R Freedberg K A French N K Fuchs JD Fuller J D Gaberman J Gallant J E Gandhi R T Garcia E Garmon D Gathe J C Jr Gaultier C R Gebre W Gilman F D Gilson I Goepfert P A Gottlieb M S Goulston C Groger R K Gurley T D Haber S Hardwicke R Hardy W D Harrigan P R Hawkins T N Heath S Hecht F M Henry W K Hladek M Hoffman R P Horton J M Hsu R K Huhn G D Hunt P Hupert M J Illeman M L Jaeger H Jellinger R M John M Johnson J A Johnson K L Johnson H Johnson K Joly J Jordan W C Kauffman C A Khanlou H Killian R K Kim A Y Kim D D Kinder C A Kirchner J T Kogelman L Kojic E M Korthuis P T Kurisu W Kwon D S LaMar M Lampiris H Lanzafame M Lederman M M Lee D M Lee J M Lee M J Lee E T Lemoine J Levy J A Llibre J M Liguori M A Little S J Liu A Y Lopez A J Loutfy M R Loy D Mohammed D Y Man A Mansour M K Marconi V C Markowitz M Marques R Martin J N Martin H L Jr Mayer K H McElrath M J McGhee T A McGovern B H McGowan K McIntyre D Mcleod GX Menezes P Mesa G Metroka CE Meyer-Olson D Miller A O Montgomery K Mounzer K C Nagami E H Nagin I Nahass R G Nelson M O Nielsen C Norene D L O'Connor D H Ojikutu B O Okulicz J Oladehin O O Oldfield E C Olender S A Ostrowski M Owen WF Jr Pae E Parsonnet J Pavlatos A M Perlmutter A M Pierce M N Pincus J M Pisani L Price L J Proia L Prokesch R C Pujet H C Ramgopal M Rathod A Rausch M Ravishankar J Rhame F S Richards C S Richman D D Rodes B Rodriguez M Rose R C 3rd Rosenberg E S Rosenthal D Ross P E Rubin D S Rumbaugh E Saenz L Salvaggio M R Sanchez WC Sanjana V M Santiago S Schmidt W Schuitemaker H Sestak P M Shalit P Shay W Shirvani V N Silebi V I Sizemore J M Jr Skolnik P R Sokol-Anderson M Sosman J M Stabile P Stapleton J T Starrett S Stein F Stellbrink H J Sterman FL Stone V E Stone D R Tambussi G Taplitz R A Tedaldi E M Telenti A Theisen W Torres R Tosiello L Tremblay C Tribble M A Trinh P D Tsao A Ueda P Vaccaro A Valadas E Vanig T J Vecino I Vega V M Veikley W Wade B H Walworth C Wanidworanun C Ward D J Warner D A Weber R D Webster D Weis S Wheeler D A White D J Wilkins E Winston A Wlodaver C G van't Wout A Wright D P Yang O O Yurdin D L Zabukovic B W Zachary K C Zeeman B Zhao M | 2010 | Science2010，330，6010： | 1 |
| 19 | Automated page orientation and skew angle detection for binary document images显示文摘 | G R Thoma H Weschler | 1994 | Pattern Recognition1994，27，10： | 1 |
| 20 | Impact of the hepatitis B virus genotype and genotype mixtures on the course of liver disease in Vietnam 显示文摘 | Toan N L Song Le H Kremsner P G Duy D N Binh V Q Koeberlein B | 2006 | Hepatology2006，43，： | 1 |
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