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| 1 | Clinically detected gastroenteropancreatic neuroendocrine tumors are on the rise: Epidemiological changes in Germany显示文摘AIM:To study the epidemiologic changes of gastroenteropancreatic neuroendocrine tumors(GEP-NET)in Germany,we analyzed two time periods 1976-1988 and1998-2006.METHODS:We evaluated epidemiological data of GEP-NET from the former East German National Cancer Registry(DDR Krebsregister,1976-1988)and its successor,the Joint Cancer Registry(GKR,1998-2006),which was founded after German reunification.Due to a particularly substantial database the epidemiological data from the federal states of Mecklenburg-Western Pomerania,Saxony,Brandenburg and Thuringia,covering a population of more than 10.8 million people,were analyzed.Survival probabilities were calculated using life table analysis.In addition,GEP-NET patients were evaluated for one or more second(non-GEP-NET)primary malignancies.RESULTS:A total of 2821 GEP neuroendocrine neoplasms were identified in the two registries.The overall incidence increased significantly between 1976 and2006 from 0.31(per 100.000 inhabitants per year)to2.27 for men and from 0.57 to 2.38 for women.In the later period studied(2004-2006),the small intestine was the most common site.Neuroendocrine(NE)neoplasms of the small intestine showed the largest absolute increase in incidence,while rectal NE neoplasms exhibited the greatest relative increase.Only the incidence of appendiceal NET in women showed little change between 1976 and 2006.Overall survival of patients varied for sex,tumor site and the two periods studied but improved significantly over time.Interestingly,about 20%of the GEP-NET patients developed one or more second malignancies.Their most common location was the gastrointestinal tract.GEP-NET patients without second malignancies fared better than those with one or more of them.CONCLUSION:The number of detected GEP-NET increased about 5-fold in Germany between 1976 and2006.At the same time,their anatomic distribution changed,and the survival of GEP-NET patients improved significantly.Second malignancies are common and influence the overall survival of GEP-NET patients.Thus,GEP-NET warrant our attention as well as intensive research on their tumorigenesis. | Hans Scherübl Brigitte Streller Roland Stabenow Hermann Herbst Michael Hopfner Christoph Schwertner Joachim Steinberg Jan Eick Wanda Ring Krishna Tiwari Soren M Zappe | 2013 | World Journal of Gastroenterology2013，19，47： | 16 |
| 2 | 在接受治疗的急性冠状动脉综合征患者中,肌钙蛋白峰值与长期缺血事件之间的关系显示文摘非ST段抬高急性冠状动脉综合征(acutecoro-narysyndromes,ACS)患者肌钙蛋白水平与结局的关系虽然已经明确,但接受抗血小板治疗管理的非ST段抬高ACS患者肌钙蛋白水平与长期结局的关系尚未明确。 | 刘莉 叶鹏 Goldstein SA Newby LK Cyr DD Neely M Lüscher TF Brown EB White HD Ohman EM Roe MT Hamm CW | 2017 | 中华高血压杂志2017，25，5： | 2 |
| 3 | The predictive value of indium - 111 leukocyte scans in the diagnosis of infected total hip, knee, or resection arthroplasties显示文摘 | Scher D M Pak K Lonner J H | 2000 | J Arthroplasty2000，15，3： | 1 |
| 4 | Overexpression of Cyclin D 1 is associated with metastatic prostate cancer to bone显示文摘 | Drobnjak M Osman I Scher HI | 2000 | Clin Cancer Res2000，6，： | 1 |
| 5 | Microencapsulation of pesticides by interracial polymerization utilizing isocyanate or aminoplast chemistry 显示文摘 | SCHER H B RODSON M LEE K S | 1998 | Pestic Sci1998，54，4： | 1 |
| 6 | Dexmedetomidine and low- dose ket- amine provide adequate sedation for awake fibreoptic intubation 显示文摘 | SCHER C S GITLIN M C | 2003 | Can J Anaesth2003，50，6： | 1 |
| 7 | Alternation drying and grinding(ADG)technique:Anovel approach for producing ride mango powder显示文摘 | Djantou E B Mbofung C M F Scher J | 2011 | LWT-Food Science and Technology2011，44，7： | 1 |
| 8 | The global burden of migraine: measuring disability in headache disorders with WHO's Classification of Functioning, Disability and Health (ICF)显示文摘 | Leonardi M Steiner TJ Scher AT | 2005 | J Headache Pain2005，6，6： | 1 |
| 9 | Cerbral infarctions in the fetus and neonate:Maternal-plancental-fetal considerations显示文摘 | Scher MS Wiznitzer M Bangert BA | 2002 | Clin Perinatal2002，29，4： | 1 |
| 10 | Comparisons of EEG sleep-specific spectral values between healthy full-term and preterm infants at comparable postconceptional ages显示文摘 | Scher MS Sun M Steppe DA | 1994 | Sleep1994，，： | 1 |
| 11 | Prospective evaluation of fecal neutrophils-derived proteins in identifying intestinal inflammation:combination of parameters does not improve diagnostic accuracy of calprotectin显示文摘 | Scher O Naumann M Shastri Y | | 0，，07： | 1 |
| 12 | Periodontal disease and the oral microbiota in new-onset rheumatoid arthritis显示文摘 | Scher JU Ubeda C Equinda M | 2012 | Arthritis Rheum2012，64，10： | 1 |
| 13 | The global burden of migraine: bmeasuring disability in headache disorders with WHO's classification of functioning, disability and health (ICF) 显示文摘 | Leonardi M Steiner TJ Scher AT | 2013 | J Headache Pain2013，6，6： | 1 |
| 14 | CRP and CD14 polymorphisms correlate with coronary plaque volume in patients with coronary artery disease – IVUS substudy of the ENCORE trials显示文摘 | Matthias Hermann Dieter Fischer Michael M. Hoffmann Theo Gasser Kurt Quitzau Thomas Meinertz Thomas Münzel Thomas F. Lüscher | 2011 | Atherosclerosis2011，，1： | 1 |
| 15 | EEG and the neuro- pathology in premature neonates with intraventricular hemor- rhage显示文摘 | Aso K Abdab-Barmada M Scher MS | 1993 | J Clin Neurophysiol1993，10，3： | 1 |
| 16 | Antitumour activity of MDV3100 in castration-resistant prostate cancer: a phase 1-2 study 显示文摘 | SCHER H I BEER T M HIGANO C S | 2010 | Lancet2010，375，9724： | 1 |
| 17 | SIRT1 regulatesthe histone methyl-transferase SUV39H1 during heterochromatinfonnation显示文摘 | Vaquero A Scher M Erdjument-Broma^e H | 2007 | Nature2007，450，7168： | 1 |
| 18 | Assessment of atherosclerosis:the role of flow-mediated dilatation显示文摘 | Charakida M Masi S Lüscher TF | 2010 | Eur Heart J2010，31，23： | 1 |
| 19 | Phenobarbital compared with phenytoin for the treatment of neonatal seizures显示文摘 | Painter M J Scher M S Stein A D | 1999 | N Engl J Med1999，341，： | 1 |
| 20 | 查看详情显示文摘 | E Wintermantel J Mayer J Blum K-L Eckert P.Lüscher M Mathey | | 0，，： | 1 |
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