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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Charge separation during the fragmentation of rime and frost 显示文摘 | Saunders C P R Hickson H Malone M D Richtofen J V | 1993 | Atmospheric Research1993，83，： | 1 |
| 3 | Human urocortin II, a new CRF -related peptide, displays selective CRF (2) -mediated action on gastric transit in rats 显示文摘 | Million M Maillot C Saunders P | 2002 | Am J Physiol Gastrointest Liver Physiol2002，282，1： | 1 |
| 4 | Endoscopic management of polypoid early colon cancer 显示文摘 | Williams C B Saunders B P Talbot I C | 2000 | World J Surg2000，24，9： | 1 |
| 5 | Laboratory studies of the charging of soft hail during ice crystal interactions显示文摘 | C P R Saunders J Hallett | 1983 | Quart J Roy Meteor Soc1983，109，： | 1 |
| 6 | Secondary lithi- um-sulfur battery显示文摘 | Yao N P Heredy L A Saunders R C | 1970 | J Electrochem Soc1970，117，： | 1 |
| 7 | The effect of liquid water on thunderstorm charging显示文摘 | W D Keith R P Mitzeva | 1991 | J Geophys Res1991，96，11： | 1 |
| 8 | A laboratory study of charge transfer accompanying the collision of ice crystals with a simulated hailstone显示文摘 | J Latham C P R Saunders | 1978 | Quart J Roy Meteor Soc1978，104，： | 1 |
| 9 | On the viscometric examination of cement pastes显示文摘 | Banfill P F G Saunders D C | 1981 | Cement and Concrete Research1981，11，3： | 1 |
| 10 | Grape cane gallmaker (Coleoptera:Curculionidae) and its impact on cultivated grapes 显示文摘 | SAUNDERS M C TOBIN P C | 2000 | Journal of Economic Entomology2000，93，3： | 1 |
| 11 | The effect of solute competition on ozonolysis of industrial dyes 显示文摘 | Saunders F M Gould J P Southerland C R | 1983 | Water Research1983，17，： | 1 |
| 12 | Minimally inva- sive reoperative isolated valve surgery zearly and mid-term re- sults显示文摘 | Sharony R Grossi E A Saunders P C | 2006 | J Card Surg2006，21，3： | 1 |
| 13 | Charge separation associated with secondary ice crystal production显示文摘 | Hallett J Saunders C P R | 1979 | J Atmos Sci1979，36，11： | 1 |
| 14 | Deinococcus geothermalis:the pool of extreme radiation resistance genes shrinks显示文摘 | Makarova K S Omelchenko M V Gaidamakova E K Matrosova V Y Vasilenko A Zhai M Lapidus A Copeland A Kim E Land M Mavrommatis K Pitluck S Richardson P M Detter C Brettin T Saunders E Lai B Ravel B Kemner K M Wolf Y I Sorokin A Gerasimova A V Gelfand M S Fredrickson J K Koonin E V Daly M J | 2007 | PloS One2007，2，9： | 1 |
| 15 | Magellan mission summary 显示文摘 | Saunders R S Spear A J Allin P C etal | 1992 | Journal of Geophysical Researeh1992，97，13： | 1 |
| 16 | Expression of oestrogen receptor beta (ER-betal) protein in human breast cancer biopsies显示文摘 | Saunders P T Millar M R Williams K Macpherson S Bayne C 0 Sullivan C Anderson T J Groome N P andMiller W R | 2002 | BritishJournal ofGancer2002，86，2： | 1 |
| 17 | The effect on thunderstorm charging of the rate of rime accretion by graupel 显示文摘 | Brooks I M Saunders C P R Mitzeva R P | 1997 | Atmos Rea1997，43，： | 1 |
| 18 | Effect of magnetic endoscope imaging on colonoscopy performance: a randomised controlled trial显示文摘 | Syed G Shah Jim C Brooker Christopher B Williams Catherine Thapar Brian P Saunders | 2000 | The Lancet2000，，9243： | 1 |
| 19 | The effect of liquid water on thunderstorm charging 显示文摘 | Saunders C P R Keith W D Mitzeva R P | 1991 | J Geophys Res1991，96，11： | 1 |
| 20 | Hyperfractionated or accelerated radiotherapy in lung cancer:an individual patient data meta-analysis显示文摘 | MAUGUEN A LE PéCHOUX C SAUNDERS M I | | 0，，22： | 1 |
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