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| 1 | Molecular mechanisms regulating NLRP3 inflammasome activation显示文摘Inflammasomes 是表明触发煽动性的 caspases 的激活和 interleukin-1β 的成熟的建筑群的多蛋白质;。在各种各样的 inflammasome 建筑群之中, NLRP3 inflammasome 最好被描绘并且与各种各样的人的 autoinflammatory 和自体免疫的疾病被连接了。因此, NLRP3 inflammasome 可以是为反煽动性的治疗的一个有希望的目标。在这评论,我们总结 NLRP3 inflammasome 被在 cytosol 激活的机制的当前的理解。我们也描述激活或禁止 inflammasome 汇编的 NLRP3 inflammasome 建筑群的有约束力的搭挡。我们调整 NLRP3 inflammasome 发信号的机制的知识并且这些怎么影响煽动性的回答,提供进一步的卓见进潜在的治疗学的策略治疗与 NLRP3 inflammasome 的 dysregulation 联系的煽动性的疾病。 | Eun-Kyeong Jo Jin Kyung Kim Dong-Min Shin Chihiro Sasakawa | 2016 | Cellular & Molecular Immunology2016，13，2： | 202 |
| 2 | An update on the regulatory mechanisms of NLRP3 inflammasome activation显示文摘The NOD-,LRR-,and pyrin domain-containing protein 3(NLRP3)inflammasome is a multiprotein complex involved in the release of mature interleukin-1βand triggering of pyroptosis,which is of paramount importance in a variety of physiological and pathological conditions.Over the past decade,considerable advances have been made in elucidating the molecular mechanisms underlying the priming/licensing(Signal 1)and assembly(Signal 2)involved in NLRP3 inflammasome activation.Recently,a number of studies have indicated that the priming/licensing step is regulated by complicated mechanisms at both the transcriptional and posttranslational levels.In this review,we discuss the current understanding of the mechanistic details of NLRP3 inflammasome activation with a particular emphasis on protein-protein interactions,posttranslational modifications,and spatiotemporal regulation of the NLRP3 inflammasome machinery.We also present a detailed summary of multiple positive and/or negative regulatory pathways providing upstream signals that culminate in NLRP3 inflammasome complex assembly.A better understanding of the molecular mechanisms underlying NLRP3 inflammasome activation will provide opportunities for the development of methods for the prevention and treatment of NLRP3 inflammasome-related diseases. | Seungwha Paik Jin Kyung Kim Prashanta Silwal Chihiro Sasakawa Eun-Kyeong Jo | 2021 | Cellular & Molecular Immunology2021，18，5： | 43 |
| 3 | ^(11)C-methionine (MET) and ^(18)F-fluorothymidine (FLT) PET in patients withnewly diagnosed glioma显示文摘Eur J Nucl Med Mol Imaging. 2008 Jun 10.PURPOSE: The purpose of this prospective study was to clarify the individual and combined role of L: -methyl-(11)C-methionine-positron emission tomography (MET-PET) and 3' -deoxy-3' -[(18)F]fluorothymidine (FLT)-PET in tumor detection,noninvasive grad-ing, and assessment of the cellular proliferation rate in newly diagnosed histologically verified gliomas of different grades. MATERI- | Hatakeyama T Kawai N Nishiyama Y Yamamoto Y Sasakawa Y Ichikawa T Tamiya T | 2008 | 中国神经肿瘤杂志2008，6，2： | 11 |
| 4 | 香港潜蝇科(双翅目)的分类研究(英文)显示文摘报道了香港22种潜蝇科昆虫,其中包括5新种、6个中国大陆新记录种。新种模式标本分藏于下列两处:Melanagromyza squamiferasp.nov.,Ophiomyiaimparispinasp.nov.,Phytomyza reduncasp.nov.的模式标本保存于日本东京自然博物馆;Melanagromyza dipetalasp.nov.,Ophiomyia vastasp.nov.的模式标本保存于美国夏威夷比肖普博物馆。 | Mitsuhiro SASAKAWA | 2006 | 昆虫学报2006，49，5： | 4 |
| 5 | Helicobacter pylori CagA Phosphorylation-Independent Function in Epithelial Proliferation and Inflammation显示文摘 | Masato Suzuki Hitomi Mimuro Kotaro Kiga Makoto Fukumatsu Nozomi Ishijima Hanako Morikawa Shigenori Nagai Shigeo Koyasu Robert H. Gilman Dangeruta Kersulyte Douglas E. Berg Chihiro Sasakawa | 2009 | Cell Host & Microbe2009，，1： | 2 |
| 6 | Molecular characterization of a surface protein antigen gene from serotype a Streptococcus mutans implicated in dental caries显示文摘 | Okahsahi N Sasakawa C Yoshikawa M | 1989 | Mol Microbiol1989，3，： | 1 |
| 7 | Diagnostic value of kinetic analysis using dynamic FDG PET in immunocompetent patients with primary CNS lymphoma显示文摘 | Nishiyama Y Yamamoto Y Monden T Sasakawa Y Kawai N Satoh K | 2007 | Eur J Nucl Med Mol Imaging2007，34，： | 1 |
| 8 | Absorption of atmospheric NO2 by plant and soil Ⅱ显示文摘 | Yoneyama T Sasakawa H Ishizuka S etal | 1979 | Soil Science and Plant Nutrition1979，25，： | 1 |
| 9 | Functional analysis of Shigella VirG domains essential for interaction with vinculin and actin-based motility显示文摘 | Suzuki T Saga S Sasakawa C | 1996 | J Biol Chem1996，271，21： | 1 |
| 10 | Antitumor efficacy of FK228, a novel histone deacetylase inhibitor, depends on the effect on expression of angiogenesis factors 显示文摘 | SASAKAWA Y NAOE Y NOTO T | 2003 | Biochem Pharmacol2003，66，6： | 1 |
| 11 | Leaf mining species of Drosophilidae(Diptera)显示文摘 | Okada T Sasakawa M | 1956 | Akitu1956，5，： | 1 |
| 12 | Advantages of Inductively Cou- pled Plasma-Assisted Sputtering for Preparation of Stoichiomctric VO2 Films with Metal-Insulator Transition 显示文摘 | Nihei Y Sasakawa Y Okimura K | 2008 | Thin Solid Films2008，516，11： | 1 |
| 13 | Bacterial evasion of the autophagic defense system显示文摘 | Ogawa M Sasakawa C | 2006 | Curr Opin Microbiol2006，，9： | 1 |
| 14 | Effect of Multiple Scattering on High-Resolution Rutherford Backscattering Spectroscopy 显示文摘 | Kaoru Sasakawa Kaoru Nakajima Motofumi Suzuki | 2012 | Nucl Instr Meth B2012，285，： | 1 |
| 15 | Virulence-associated genetic regions comprising 31 kilobases of the 230- kilobase plasmid in Shigella flexneri 2a 显示文摘 | Sasakawa C Kamata K Sakai T | 1988 | J Bacteriol1988，170，6： | 1 |
| 16 | Control of epithelial cell structure and developmental fate: lessons from Helicobacter pylori 显示文摘 | Mimuro H Berg DE Sasakawa C | 2008 | BioEssays2008，30，6： | 1 |
| 17 | Identification of a novel gene,dep,associated with depolymerization of the capsular polymer in Bacillus anthracis 显示文摘 | Uchida I Makino S Sasakawa C | 1993 | Mol Microbiol1993，9，3： | 1 |
| 18 | Diagnostic value of kinetic analysis using dynamic FDG PET in immunocompetent patients with primary CNS lymphoma显示文摘 | Yoshihiro Nishiyama Yuka Yamamoto Toshihide Monden Yasuhiro Sasakawa Nobuyuki Kawai Katashi Satoh Motoomi Ohkawa | 2007 | European Journal of Nuclear Medicine and Molecular Imaging2007，，1： | 1 |
| 19 | Advantages of Inductively Cou- pled Plasma-Assisted Sputtering for Preparation of Stoichiometric VO2 Films with Metal-Insulator Transition 显示文摘 | Nihei Y Sasakawa Y Okimura K | 2008 | Thin Solid Films2008，516，11： | 1 |
| 20 | Effect of multiple scattering on high-resolution Rutherford backscattering spectroscopy显示文摘 | KAORU SASAKAWA KAORU NAKAJIMA MOTOFUMI SUZUKI | | 0，，： | 1 |
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