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| 1 | Mathematical modeling of drug release from biodegradable polymeric microneedles显示文摘Transdermal drug delivery systems have overcome many limitations of other drug administration routes,such as injection pain and first-pass metabolism following oral route,although transdermal drug delivery systems are limited to drugs with low molecular weight.Hence,new emerging technology allowing high molecular weight drug delivery across the skin—known as‘microneedles’—has been developed,which creates microchannels that facilitate drug delivery.In this report,drug-loaded degradable conic microneedles are modeled to characterize the degradation rate and drug release profile.Since a lot of data are available for polylactic acid-co-glycolic acid(PLGA)degradation in the literature,PLGA of various molecular weights-as a biodegradable polymer in the polyester family-is used for modeling and verification of the drug delivery in themicroneedles.The main reaction occurring during polyester degradation is hydrolysis of steric bonds,leading to molecular weight reduction.The acid produced in the degradation has a catalytic effect on the reaction.Changes in water,acid and steric bond concentrations over time and for different radii of microneedles are investigated.To solve the partial and ordinary differential equations simultaneously,finite difference and Runge–Kutta methods are employed,respectively,with the aid of MATLAB.Correlation of the polymer degradation rate with its molecular weight and molecular weight changes versus time are illustrated.Also,drug diffusivity is related to matrix molecular weight.The molecular weight reduction and accumulative drug release within the system are predicted.In order to validate and assess the proposed model,data series of the hydrolytic degradation of aspirin(180.16 Da)-and albumin(66,000 Da)-loaded PLGA(1:1 molar ratio)are used for comparison.The proposed model is in good agreement with experimental data from the literature.Considering diffusion as themain phenomena and autocatalytic effects in the reaction,the drug release profile is predicted.Based on our results for a microneedle containing drug,we are able to estimate drug release rates before fabrication. | Sarvenaz Chavoshi Mohammad Rabiee Mehdi Rafizadeh Navid Rabiee Alireza Shahin Shamsabadi Mojtaba Bagherzadeh Reza Salarian Mohammadreza Tahriri Lobat Tayebi | 2019 | Bio-Design and Manufacturing2019，2，2： | 1 |
| 2 | Size-specific dose estimates: Localizer or transverse abdominal computed tomography images?显示文摘AIM: To investigate effect of body dimensions obtained from localizer radiograph and transverse abdominal computed tomography(CT) images on Size Specific Dose Estimate. METHODS: This study was approved by Institutional Review Board and was compliant with Health Insurance Portability and Accountability Act. Fifty patients with abdominal CT examinations(58 ± 13 years, Male: Female 28:22) were included in this study. Anteriorposterior(AP) and lateral(Lat) diameters were measured at 5 cm intervals from the CT exam localizer radiograph(simple X-ray image acquired for planning the CT exam before starting the scan) and transverse CT images. Average of measured AP and Lat diameters, as well as maximum, minimum and mid location AP and Lat were measured on both image sets. In addition, off centering of patients from the gantry iso-center was calculated from the localizers. Conversion factors from American Association of Physicists in Medicine(AAPM) report 204 were obtained for AP, Lat, AP + Lat, and effective diameter(√ AP * Lat) to determine size specificdose estimate(SSDE) from the CT dose index volume(CTDIvol) recorded from the dose reports. Data were analyzed using SPSS v19. RESULTS: Total number of 5376 measurements was done. In some patients entire body circumference was not covered on either projection radiograph or transverse CT images; hence accurate measurement of AP and Lat diameters was not possible in 11%(278/2488) of locations. Forty one patients were off-centered with mean of 1.9 ± 1.8 cm(range: 0.4-7 cm). Conversion factors for attained diameters were not listed on AAPM look-up tables in 3%(80/2488) of measurements. SSDE values were significantly different compared to CTDIvol, ranging from 32% lower to 74% greater than CTDIvol. CONCLUSION: There is underestimation and overestimation of dose comparing SSDE values to CTDIvol. Localizer radiographs are associated with overestimation of patient size and therefore underestimation of SSDE. | Sarvenaz Pourjabbar Sarabjeet Singh Atul Padole Akshay Saini Michael A Blake Mannudeep K Kalra | 2014 | World Journal of Radiology2014，6，5： | 1 |
| 3 | ITIL Adoption Model Based on TAM显示文摘 | Sarvenaz Mehravani Nastaran Hajiheydari | 2011 | ACSIT Press2011，，5： | 1 |
| 4 | Metastasis markers in bladder cancer: A review of the literature and clinical considerations 显示文摘 | Paolo Gontero Sarvenaz Banisadrb Bruno Freaa | 2004 | Eur Urol2004，46，3： | 1 |
| 5 | Ultra low-dose chest CT using filtered back projection: Comparison of 80-, 100- and 120kVp protocols in a prospective randomized study显示文摘 | Ranish Deedar Ali Khawaja Sarabjeet Singh Rachna Madan Amita Sharma Atul Padole Sarvenaz Pourjabbar Subba Digumarthy Jo-Anne Shepard Mannudeep K. Kalra | 2014 | European Journal of Radiology2014，，10： | 1 |
| 6 | Radiation Dose Optimization and Thoracic Computed Tomography显示文摘 | Sarabjeet Singh Mannudeep K. Kalra Ranish Deedar Ali Khawaja Atul Padole Sarvenaz Pourjabbar Diego Lira Jo-Anne O. Shepard Subba R. Digumarthy | 2014 | Radiologic Clinics of North America2014，，： | 1 |
| 7 | Preliminary Results: Prospective Clinical Study to Assess Image-Based Iterative Reconstruction for Abdominal Computed Tomography Acquired at 2 Radiation Dose Levels显示文摘 | Sarvenaz Pourjabbar Sarabjeet Singh Anand K. Singh Rocio P. Johnston Anuradha S. Shenoy-Bhangle Synho Do Atul Padole Michael A. Blake Anders Persson Mannudeep K. Kalra | 2014 | Journal of Computer Assisted Tomography2014，，： | 1 |
| 8 | Assessment of sub-milli-sievert abdominal computed tomography with iterative reconstruction techniques of different vendors显示文摘AIM: To assess diagnostic image quality of reduced dose(RD) abdominal computed tomography(CT) with 9 iterative reconstruction techniques(IRTs) from 4 different vendors to the standard of care(SD) CT.METHODS: In an Institutional Review Board approved study, 66 patients(mean age 60 ± 13 years, 44 men, and 22 women) undergoing routine abdomen CT on multi-detector CT(MDCT) scanners from vendors A, B, and C(≥ 64 row CT scanners)(22 patients each) gave written informed consent for acquisition of an additional RD CT series. Sinogram data of RD CT was reconstructed with two vendor-specific and a vendor-neutral IRTs(A-1, A-2, A-3; B-1, B-2, B-3; and C-1, C-2, C-3) and SD CT series with filtered back projection. Subjective image evaluation was performed by two radiologists for each SD and RD CT series blinded and independently. All RD CT series(198) were assessed first followed by SD CT series(66). Objective image noise was measured for SD and RD CT series. Data were analyzed by Wilcoxon signed rank, kappa, and analysis of variance tests.RESULTS: There were 13/50, 18/57 and 9/40 missed lesions(size 2-7 mm) on RD CT for vendor A, B, and C, respectively. Missed lesions includes liver cysts, kidney cysts and stone, gall stone, fatty liver, and pancreatitis. There were also 5, 4, and 4 pseudo lesions(size 2-3 mm) on RD CT for vendor A, B, and C, respectively. Lesions conspicuity was sufficient for clinical diagnostic performance for 6/24(RD-A-1), 10/24(RD-A-2), and 7/24(RD-A-3) lesions for vendor A; 5/26(RD-B-1), 6/26(RD-B-2), and 7/26(RD-B-3) lesions for vendor B; and 4/20(RD-C-1) 6/20(RD-C-2), and 10/20(RD-C-3) lesions for vendor C(P = 0.9). Mean objective image noise in liver was significantly lower for RD A-1 compared to both RD A-2 and RD A-3 images(P < 0.001). Similarly, mean objective image noise lower for RD B-2(compared to RD B-1, RD B-3) and RD C-3(compared to RD C-1 and C-2)(P = 0.016).CONCLUSION: Regardless of IRTs and MDCT vendors, abdominal CT acquired at mean CT dose index volume 1.3 m Gy is not sufficient to retain clinical diagnostic performance. | Atul Padole Nisha Sainani Diego Lira Ranish Deedar Ali Khawaja Sarvenaz Pourjabbar Roberto Lo Gullo Alexi Otrakji Mannudeep K Kalra | 2016 | World Journal of Radiology2016，8，6： | 1 |
| 9 | Assessment of Filtered Back Projection, Adaptive Statistical, and Model-Based Iterative Reconstruction for Reduced Dose Abdominal Computed Tomography显示文摘 | Atul Padole Sarabjeet Singh Diego Lira Michael A. Blake Sarvenaz Pourjabbar Ranish Deedar Ali Khawaja Garry Choy Sanjay Saini Synho Do Mannudeep K. Kalra | 2015 | Journal of Computer Assisted Tomography2015，，： | 1 |
| 10 | Computed Tomography (CT) of the Chest at Less Than 1 mSv: An Ongoing Prospective Clinical Trial of Chest CT at Submillisievert Radiation Doses with Iterative Model Image Reconstruction and iDose4 Technique显示文摘 | Ranish Deedar Ali Khawaja Sarabjeet Singh Matthew Gilman Amita Sharma Synho Do Sarvenaz Pourjabbar Atul Padole Diego Lira Kevin Brown Jo-Anne O. Shepard Mannudeep K. Kalra | 2014 | Journal of Computer Assisted Tomography2014，，4： | 1 |
| 11 | China-Iran strategic cooperation agreement in the changing international system显示文摘Since the outbreak of the COVID-19 pandemic,the international political and economic system has changed dramatically.The Western powers are in decline,while the non-western Asian and Eurasian powers are rising.The three-century-long Western dominated international system is giving way to a mixed system with Global North and Global South playing predominant roles simultaneously.In face of the changing international system,China and Iran are promoting strategic docking,and their relations have been updated from the comprehensive strategic partnership in 2016 to the 25-Year Strategic Cooperation Agreement in 2021.This development demonstrates the resilience of China’s strategic partnerships in the Middle East,and is conducive to building a more balanced international system and fostering South-South cooperation.The updated Sino-Iranian relations is defensive,and it does not target any third party,nor does it change China’s non-alignment policy in the Middle East.It is conducive to promoting regional reconciliation between Iran and Saudi-led Arab countries. | Sarvenaz Khanmohammadi Degang Sun | 2022 | Asian Journal of Middle Eastern and Islamic Studies2022，16，1： | 0 |
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