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| 1 | Insulin receptors in the kidneys in health and disease显示文摘Insulin is an important hormone that affects various metabolic processes,including kidney function.Impairment in insulin's action leads to insulin resistance in the target tissue.Besides defects in post-receptor insulin signaling,impairment at the receptor level could significantly affect insulin sensitivity of the target tissue.The kidney is a known target of insulin;however,whether the kidney develops 'insulin resistance' is debatable.Regulation of the insulin receptor(IR) expression and its function is very well studied in major metabolic tissues like liver,skeletal muscles,and adipose tissue.The physiological relevance of IRs in the kidney has recently begun to be clarified.The credit goes to studies that showed a wide distribution of IR throughout the nephron segments and their reduced expression in the insulin resistance state.Moreover,altered renal and systemic metabolism observed in mice with targeted deletion of the IR from various epithelial cells of the kidney has strengthened this proposition.In this review,we recapitulate the crucial findings from literature that have expanded our knowledge regarding the significance of the renal IR in normal-and insulin-resistance states. | Sarojini Singh Rajni Sharma Manju Kumari Swasti Tiwari | 2019 | World Journal of Nephrology2019，8，1： | 3 |
| 2 | Elevation of gene expression of calcineurin,calmodulin and calsyntenin in oxidative stress induced PC12 cells显示文摘In normal physiological conditions,reactive oxygen and nitrogen species are used as important signaling molecules in the cell.However,in excess it causes the disruption of cell resulting in their death.Oxidative stress causes influx in intracellular calcium levels leading to higher concentrations of calcium in the cell.This accelerated calcium affects both the mitochondria and nuclei leading to excitotoxicity in neurons.Intracellular calcium levels are controlled by voltage dependent calcium channels located in the plasma membrane,calcium stores like endoplasmic/sarcoplasmic reticulum and majorly by calcium binding proteins.Our study was aimed at analyzing the gene expression of major calcium binding proteins namely calcineurin,calmodulin,calreticulin,synaptotagamin and calsyntenin in stress induced PC 12 cells.Rotenone(1 mM),Peroxynitrite(10 mM),H_(2)O_(2)(100 mM)and High glucose(33 mM)were used to induce oxidative stress in PC12 cells.Results obtained from the study suggest that calcineurin,calmodulin and calsyntenin gene expression were enhanced compared to the control due to oxidative stress.However,synaptotagmin and calreticulin gene expression were down regulated.Further,Akt protein expression(stress marker)was enhanced in PC12 cells with all other stress inducers except in hyperglycemic condition. | P.Aravind Sarojini R.Bulbule N.Hemalatha R.L.Babu K.S.Devaraju | 2021 | Genes & Diseases2021，8，1： | 3 |
| 3 | Comparison of the effects of androgenic hormone and testoster-one propionate on the female ocypod crab显示文摘 | Sarojini S | 1963 | Curr Sci1963，33，9： | 1 |
| 4 | Biogenic amines in crustaceans:identification,localization,and roles显示文摘 | FINGERMAN M NAGABHUSHANAM R SAROJINI R | 1994 | J Crust Biol1994，14，3： | 1 |
| 5 | Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts显示文摘 | Maes OC Sarojini H Wang E | 2009 | J Cell Physiol2009，221，1： | 1 |
| 6 | 5-Hydroxytryptaminergic control of testes development through the androgenic gland in the red swamp crayfish,Procambarus clarkii显示文摘 | SAROJINI R NAGABHUSHANAM R FINGERMAN M | 1994 | Invert Reprod Develop1994，26，2： | 1 |
| 7 | Biogenic amines in crustaceans:identification,localzation,and roles显示文摘 | Fingerman M Nagabhushanam R Sarojini R | 1994 | J Crust Biol1994，14，3： | 1 |
| 8 | One pot syn- thesis of thiazolodihydropyrimidinones and evaluation oftheir anticancer activity显示文摘 | Holla B S Rao B S Sarojini B K et ol | 2004 | Eur J Med Chem2004，39，9： | 1 |
| 9 | Dopaminergic inhibition of 5-hydroxytryptamine-stimulated testicular maturation in the fiddler crab,Uca pugilator显示文摘 | SAROJINI R NAGABHUSHANAM R DEVI M | 1995 | Comp Biochem Physiol1995，111，： | 1 |
| 10 | Mode of action of the neurotransmitter 5- hydroxytryptamine in stimulating ovarian maturation in the red swamp crayfish,Procambarus clarkii : An in vivo and in vitro study 显示文摘 | SAROJINI R NAGABHUSHANAM R FINGERMAN M | 1995 | Journal of Experimental Zoology1995，271，5： | 1 |
| 11 | Antimicrobial,analgesic,DPPH scavenging activities and molecular docking study of some 1,3,5-triaryl-2-pyrazolines显示文摘 | SAMSHUDDIN S NARAYANA B SAROJINI B K | | 0，，8： | 1 |
| 12 | Antltumor effect of 2-methoxyestradiol in a rat orthotopic brain tumor model显示文摘 | SEUNC -HEE KANG HEIDI T CliO SAROJINI DEVI | 2006 | Cancer Res2006，66，11： | 1 |
| 13 | Synthesis and Studies on Some New Fluorine Containing Triazolothiadiazines as Possible Antibacterial, Antifungal and Anticancer Agents 显示文摘 | Holla B S Rao S B Sarojini B K | 2006 | Eur J Med Chem2006，41，5： | 1 |
| 14 | Vertebrate-type hormones in crustaceans-loealization,identification and functional significance显示文摘 | Fingerman M Nagabhushanam R Sarojini R | 1993 | Zoological Science1993，10，1： | 1 |
| 15 | Cholesterol-reduced Fats,They′re Here显示文摘 | ANON S SAROJINI R MIRAJAKAR M S | 1989 | Prepared Foods1989，158，7： | 1 |
| 16 | Methyl4-(bromomethyl)benzoate显示文摘 | YATHIRAJAN H S BINDYA S SAROJINI BK NARAYANAC B BOLTED M | 2007 | Acta Cryst2007，63，3： | 1 |
| 17 | Use of colchicine in the management of erythema nodosum leprosum(Enl)显示文摘 | Sarojini PA Mshana RN | 1983 | Lepr Rev1983，54，2： | 1 |
| 18 | Inflammatory markers-serum level of c-reactive protein,tumor necrotic factor-a,and interleukin-6 as predictors of outcome for perip- artuin cardiomyopathy 显示文摘 | Sarojini A Sai Ravi Shanker A Anitha M | 2013 | J Obstetrics Gynaecology India2013，63，4： | 1 |
| 19 | 查看详情显示文摘 | Holla B.S Malini K.V Rao B.S Sarojini B.K Kumari N.S | | 0，，： | 1 |
| 20 | A Study of Retinal Penetration of Intravitreal Tenecteplase in Pigs显示文摘 | Anthony S Kwan L Sarojini V | 2006 | Inves Ophthalmol Vis Sci2006，47，6： | 1 |
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