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| 1 | 服用抗氧化剂降低老年人血清脂质过氧化物——随机双盲临床试验显示文摘给某老年人护理院的45位老人服用β-胡萝卜素,维生素B_6,维生素C,维生素E,锌和硒,或者相应的安慰剂作为日常食物的补充,为期一年。开始时,这些老年人的血清脂质过氧化物水平(2.7±0.7μmol/L)高于作为对照组的年轻健康成年人(2.3±0.6μmol/L),P<0.01。服药三个月后,老年人的血清脂质过氧化物已降至2.2±0.6μmol/L,并且保持这一低水平直到研究结束,而服安慰剂者血清脂质过氧化物无变化。 血清脂质过氧化物与全血硒浓度呈显著负相关(r=-0.428,P<0.01),但只有在血硒高于200μg/L时才可见血清脂质过氧化物的降低。血清α-维生素E浓度也与血清脂质过氧化物呈负相关,但相关程度(r=-0.273,P<0.76)低于与血硒间的相关。 从生物化学角度看,25%的老年人可观察到维生素B_6缺乏;每天补充2mg维生素B_6彻底治愈了全部的病例。服药组经几项心理学检验有轻微改善,而服用安慰剂的对照组无变化或者恶化。护士报告在服药组中见有临床改善,未见有毒性副作用。老年人服用抗氧化剂从生物化学和临床上都是有益的。 | Matti Tolonen Seppo Sarna Tuomas Westermarck Markku Halme Ulla-Riitta Nordberg Mirja Keinonen Jaap Schrijver Seppo E.J.Tuominen 杨旭冬 | 1989 | 营养学报1989，11，1： | 3 |
| 2 | Association of Helicobacter pylori IgA antibodies with the risk of peptic ulcer disease and gastric cancer显示文摘AIM: To compare the prevalence of Helicobacter pylori (Hpylori) IgG and IgA antibodies between adult subjects,with defined gastric diseases, nondefined gastric disorders and those representing the population.METHODS: Data on H pylori IgG and IgA antibodies,determined by enzyme immunoassay, were analyzed in 3 252 subjects with DGD including 482 patients with gastric ulcer, 882 patients with duodenal ulcer, 1 525patients with chronic gastritis only and 363 subjects with subsequent gastric cancer, 19 145 patients with NoDg and4 854 POPUL subjects. The age-adjusted prevalences were calculated for 1- and 20-year age cohorts.RESULTS: The prevalences of IgG antibodies were equally high (89-96%) in all 20-year age cohorts of the DGD groups, whereas the prevalences of IgG antibodies were lower and increased by age in the POPUL and NoDg groups. The prevalences of IgA antibodies were also higher in the DGD groups; among them CA (84-89%) and GU groups (78-91%) showed significantly higher prevalences than DU (68-77%) and CG patients (59-74%) (OR 2.49, 95%CI 1.86-3.34 between the GU and DU groups). In the CA, GU, and DU groups, the IgA prevalences showed only minor variation according to age, while they increased by age in the CG, POPUL, and NoDg groups (P≤0.0001). The IgA response, but not the IgG response, was associated with an increased risk of CA (OR 2.41, 95%CI 1.79-3.53) and GU (OR 2.57,95%CI 1.95-3.39) in comparison with CG patients.CONCLUSION: An IgA antibody response during H pylori infection is significantly more common in CA and GU patients as compared with CG patients. | Timo U Kosunen Kari Seppl Seppo Sarna Arpo Aromaa Paul Knekt Jarmo Virtamo Anniina Salomaa-Rsnen Hilpi Rautelin | 2005 | World Journal of Gastroenterology2005，11，43： | 3 |
| 3 | Smoking,the missing drug interaction in clinical trials:ignoring the obvious显示文摘 | Griz ER Dresler C Sarna L | 2005 | Cancer Epidemiol Biomarkers Prev2005，14，10： | 1 |
| 4 | Correlates of symptom distress in women with lung cancer显示文摘 | Sarna L | 1993 | Cancer Pract1993，1，1： | 1 |
| 5 | Experimental missile wound to the brain显示文摘 | Carey ME Sarna GS Farrell JB | 1989 | J Neurosurg1989，71，5： | 1 |
| 6 | Contractile mech - anisms of gallbladder filling and emptying in dog显示文摘 | Abiru H Sarna SK Condon RE | 1994 | Gastroen - terology1994，106，6： | 1 |
| 7 | Low dose intrathecal ropivacaine and sufentanil is safe and dose not impair motor strength 显示文摘 | Soni AK Sarna MC Miler CG | 1997 | Anesthasiology1997，87，： | 1 |
| 8 | Increased life expectancy of world class male athletes显示文摘 | Sarna S Sahi T Koskenvuo M | 1993 | Med Sci Sports Exerc1993，25，2： | 1 |
| 9 | Role of ocular melanin in ophthalmic physiology and pathology 显示文摘 | Hu DN Simon JD Sarna T | 2008 | Photochem Photobiol2008，84，： | 1 |
| 10 | Paw and limb use in skilled and spontaneous reaching after pyramidal tract, red nucleus and combined lesions in the rat: behavioral and anatomical dissociations显示文摘 | Whishaw IQ Gorny B Sarna J | 1998 | Behav Brain Res1998，93，12： | 1 |
| 11 | Prevalence of coronary heart disease and risk factors in an urban Indian population: Jaipir Heart Watch-2 显示文摘 | Gup ta Rajeev Gup ta VP Sarna Mukesh | 2002 | Indian Heart J2002，54，1： | 1 |
| 12 | Quality of life of long-term survivors of non-small-cell lung cancer 显示文摘 | Sarna L Padilla G Holmes C | 2002 | Journal of Clinical Oncology2002，20，13： | 1 |
| 13 | Clinically meaningful differences in patient-reported out comes with amifostine in combination with chemo radiation for locally advanced non - small - cell lung canc- er;an analysis of RTOG 9801 显示文摘 | L Sarna S swarm CLanger | 2008 | Int J Radiat Oncol Biol Phys2008，72，5： | 1 |
| 14 | Photocytotoxicity of lipofuscin in human retinal pigment epithelial cells 显示文摘 | DAVIES S ELLIOTT M H FLOOR E TRUSCOTT T G ZAREBA M SARNA T SHAMSIF A BOULTON M E | 2001 | Free Radic Biol Med2001，31，2： | 1 |
| 15 | Use of complementary and alternative medicine therapies to control symptoms in women living with lung cancer显示文摘 | Wells M Sarna L Cooley ME | 2007 | Cancer Nurs2007，30，1： | 1 |
| 16 | Antioxidant properties of human iridial melanin显示文摘 | SARNA T J WIELGUS A SKUMATZ C M | 2003 | Investigative Ophthalmology & Visual Science2003，44，5： | 1 |
| 17 | Quality of life of long-term survivors of non-small-cell lung cancer显示文摘 | Sarna L Padilla G Holmes C | 2002 | J Clin Oncol2002，20，13： | 1 |
| 18 | Nurses'Tobacco-relatedKnowledge,Attitudes,and Practice in Four Major Cities in China显示文摘 | Chan S S Sarna L Wong D C | 2007 | Journal of Nursing Scholarship2007，39，： | 1 |
| 19 | Types of human colonic dectrical activities recorded postoperatively显示文摘 | Sarna SK | 1981 | Gastroenterology1981，81，1： | 1 |
| 20 | Cause an effect relationship between motilin and the migrating myoelectric complex显示文摘 | Sarna S | 1983 | J Am Physiol1983，245，： | 1 |
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