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| 1 | Nocardia infections among immunomodulated inflammatory bowel disease patients:A review显示文摘Human nocardiosis,caused by Nocardia spp.,an ubiquitous soil-borne bacteria,is a rare granulomatous disease close related to immune dysfunctions.Clinically can occur as an acute life-threatening disease,with lung,brain and skin being commonly affected.The infection was classically diagnosed in HIV infected persons,organ transplanted recipients and long term corticosteroid treated patients.Currently the widespread use of immunomodulators and immunossupressors in the treatment of inflammatory diseases changed this scenario.Our purpose is to review all published cases of nocardiosis in immunomodulated patients due to inflammatory diseases and describe clinical and laboratory findings.We reviewed the literature concerning human cases of nocardiosis published between 1980 and 2014 in peer reviewed journals.Eleven cases of nocardiosis associated with anti-tumor necrosis factor(TNF) prescription(9 related with infliximab and 2 with adalimumab) were identified; 7 patients had inflammatory bowel disease(IBD),4 had rheumatological conditions; nocardia infection presented as cutaneous involvement in 3 patients,lung disease in 4 patients,hepatic in one and disseminated disease in 3 patients.From the 10 cases described in IBD patients 7 were associated with anti-TNF and 3 with steroids and azathioprine.In conclusion,nocardiosis requires high levels of clinical suspicion and experience of laboratory staff,in order to establish a timely diagnosis and by doing so avoid worst outcomes.Treatment for long periods tailored by the susceptibility of the isolated species whenever possible is essential.The safety of restarting immunomodulators or anti-TNF after the disease or the value of prophylaxis with cotrimoxazole is still debated. | Candida Abreu Nuno Rocha-Pereira António Sarmento Fernando Magro | 2015 | World Journal of Gastroenterology2015，21，21： | 18 |
| 2 | 青少年和年轻成人先天性心脏病的心理社会远期转归显示文摘目的先天性心脏病(CHD)是一种在全球范围内高发的慢性疾病,通常在出生时或出生前确诊。由于诊断以及早期药物和手术治疗的条件较好,患者的生存率达到90%,并且生存时间不断延长,面临着生活中的各种挑战。该研究探讨了不同人口统计学、临床和心理社会变量对CHD青少年和年轻成人患者的生活质量(QOL)感知、心理社会适应和精神障碍患病率的影响,评估CHD青少年和年轻成人患者的生活质量、心理社会适应和精神障碍发病率,确定哪些变量(人口统计学、临床和心理社会变量)对缓解压力、促进恢复起到积极作用,哪些变量起到不良作用。方法该研究入组了150名CHD患者(男87例,女63例),年龄12~26岁(平均年龄:17.45±3.373岁)。对参与者进行了关于社会支持、家庭教育方式、自我形象、人口统计信息和生理限制等方面的访谈。他们对标准化精神病学访谈(SADS-L)中的问题进行了回答,并填写了自我报告问卷,以进行生活质量(WHOQOL-BREF)和心理社会适应(YSR/ASR)的评估。结果所有参与者精神障碍的终身患病率为18.7%(女性25.4%,男性13.8%)。57.1%的参与者有过留级(平均1.53±0.804年)。与整体葡萄牙人相比,CHD患者的生活质量感知在社会关系、环境、身体和总体方面较好。而女性、学习成绩差、较少的社会支持、复杂性CHD、紫绀型CHD、中重度残留病灶、接受过手术和有生理限制患者生活质量感知较差。除了紫绀,所有这些变量也会引起较差的心理社会适应。结论女性CHD患者及学习成绩差且获得社会支持少的CHD患者的心理社会适应和生活质量较差。 | Maria Emlha Gulmaraes Arelas Catarina I. Pinto Patricia F. Vieira Flavio Teixeira Rosalia. Coelho Isabela Freitas Samantha Matos Marta Castro Sofia Sarmento Victor Viana Jorge Quintas Jose C. Areias | 2013 | 中国当代儿科杂志2013，15，10： | 3 |
| 3 | Starch Digestibility and Physicochemical and Cooking Properties of Irradiated Rice Grains显示文摘This study evaluated the starch digestibility, physicochemical properties and cooking characteristics of polished rice(varieties IRGA417 and IAC202) subjected to the doses of 0(as the control), 1, 2 and 5 k Gy of gamma radiation. The highest dose decreased the apparent amylose content, peak viscosity, water absorption and volume expansion. Irradiation increased the solid loss by 119% and 187% for IAC202 and IRGA417, respectively, when comparing the higher dose with the control. For IAC202, irradiation decreased the rapidly digestible starch and increased the slowly digestible starch(SDS) and resistant starch(RS). IRGA417 showed an elevation of SDS and a reduction in RS. And 1 k Gy dose of gamma radiation generated the highest level of RS for both the two varieties and presented the smallest changes in other physicochemical and cooking properties. | Luís Fernando POLESI Manoel Divino da MATTA JUNIOR Silene Bruder Silveira SARMENTO Solange Guidolin CANNIATTI-BRAZACA | 2017 | Rice science2017，24，1： | 3 |
| 4 | A multi-agent data mining system for cartel detection in Brazilian government procurement显示文摘 | Célia Ghedini Ralha Carlos Vinícius Sarmento Silva | 2012 | Expert Systems With Applications2012，，14： | 2 |
| 5 | A prospective cancer chemo-immunotherapy approach mediated by synergistic CD326 targeted porous silicon nanovectors显示文摘经由 nanoparticulate 系统的联合治疗已经为癌症治疗作为一条 synergistic 途径被建议了。此处, undecylenic 酸热地修改了多孔的硅 nanoparticles (UnTHCPSi NP ) 与 sorafenib 装载了的 hydrocarbonized,有 anti-CD326 抗体(Ab ) 的 surface-biofunctionalized 在 MCF-7 和 MDA-MB-231 乳癌房间为癌症 chemo 免疫疗法被开发。cytocompatibility 学习没在比 200 g 低的集中为赤裸、结合抗体的 UnTHCPSi (Un-Ab ) NP 显示出重要毒性 ? 浩汰楹杮愠搠 ' 糖锚?湩琠敨漠潸桰汩捩瑩 ? 景琠敨猠牵慦散倠 ? 瑡浯吗? | Mohammad-Ali Shahbazi Neha Shrestha Ermei Makila Francisca Araujo Alexandra Correia Tomas Ramos Bruno Sarmento Jarno Salonen Jouni Hirvonen Helder A. Santos | 2015 | Nano Research2015，8，5： | 2 |
| 6 | Acute paraquat poisoning:report of a survival case following intake of a potential lethal dose显示文摘 | Dinis-Oliveira RJ Sarmento A Reis P | 2006 | Pediatr Emerg Care2006，22，7： | 1 |
| 7 | Alginate/chitosan nanoparticles are effective for oral insulin delivery显示文摘 | Sarmento B Ribeiro A Veiga F | 2007 | Pharm Res2007，24，12： | 1 |
| 8 | Acute paraquat poisoning:report of a survival case following intake of a potential lethal dose显示文摘 | DINIS-OLIVEIRA R J SARMENTO A REIS P | 2006 | Pediatr Emerg Care2006，22，7： | 1 |
| 9 | Virtual and real-estate science and technology parks: A case study of Taguspark 显示文摘 | Dur D Sarmento M Varela V and Mahez L | 2005 | Technovation2005，25，3： | 1 |
| 10 | Acute paraquat poisoning: report of a survival case following intake of a potential lethal dose 显示文摘 | Dinis-Oliveira R J Sarmento A Reis P | 2006 | Pediatr Emerg Care2006，22，7： | 1 |
| 11 | Notchl modulates timing of G1-S progression by inducing SKP2 transcription and p27 Kipl degradation 显示文摘 | Sarmento LM Huang H Limon A | 2005 | J Exp Med2005，202，1： | 1 |
| 12 | Wave flume experiments on two-dimensional oscillating water column wave energy devices显示文摘 | A. J. N. A. Sarmento | 1992 | Experiments in Fluids (-)1992，，4： | 1 |
| 13 | A double-blind randomised clinical trial of two techniques for gingival displacement显示文摘 | Sarmento HR Leite FR Dantas RV | 2014 | J Oral Rehabil2014，41，4： | 1 |
| 14 | Doxorubicin biocompatible O/W micro- emulsion stabilized by mixed surfactant containing soya phosphatidylcholine 显示文摘 | FORMARIZ T P SARMENTO V H SILVA-JUNIOR A A | 2006 | Colloids Surf B Biointerfaces2006，51，1： | 1 |
| 15 | Sea state characterisation of the test site of an offshore wave energy plant显示文摘 | Jo?o M.B.P. Cruz António J.N.A. Sarmento | 2006 | Ocean Engineering2006，，5： | 1 |
| 16 | Warming effects on marine microbial food web processes: how far can we go when it comes to predictions? 显示文摘 | Sarmento H Montoya J M VOzquez-Dominguez E | 2010 | Philosophical Transactions of the Royal Society B: Biological Sciences2010，365，1549： | 1 |
| 17 | Comparative value of BNP and NT - proBNP in diagnosis of heart failure显示文摘 | Fonseca C Sarmento PM Minez A | 2004 | Rev Port Cardiol2004，23，78： | 1 |
| 18 | Thermodynamical properties of the Spin-one transverse ising model显示文摘 | SARMENTO E P KANEYOSHI T | 1992 | Physica A1992，186，： | 1 |
| 19 | Effect of age on the pathogenesis and innate immune responses in Pekin ducks infected with different H5N1 highly pathogenic avian influenza viruses显示文摘 | Mary J. Pantin-Jackwood Diane M. Smith Jamie L. Wasilenko Caran Cagle Eric Shepherd Luciana Sarmento Darrell R. Kapczynski Claudio L. Afonso | 2012 | Virus Research2012，，2： | 1 |
| 20 | Surface magnetic properties of the Ising model with a diluted free surface显示文摘 | Kaniyoshi T Tamura I Sarmento E F | 1983 | Phys Rew B1983，28，11： | 1 |
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