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| 1 | 血管抑素玻璃体注射对糖尿病大鼠视网膜及虹膜血管渗漏的影响显示文摘目的 探讨血管抑素(Angiostatin)玻璃体腔注射对糖尿病大鼠视网膜、虹膜血管渗漏性的影响及其机理。方法 Brown Norway大鼠48只。静脉注射链唑霉素(Streptozotocin,STZ)建立糖尿病模型,随机分为3组(每组糖尿病鼠与正常鼠各8只)。甲组:右眼玻璃体腔注射磷酸盐缓冲生理盐水(Phosphate Buffered Saline,PBS)5山,左眼不注射;乙组、丙组:右眼玻璃体腔注射血管抑素7.5μg/5μl,左眼注射等量PBS;甲、乙组用埃文斯蓝微血管渗透性检测法检测视网膜和虹膜的血管渗透性。丙组用Western blot免疫印迹分析法检测视网膜血管内皮生长因子(Vascular Endothelial Growth Factor,VEGF)的表达。结果 糖尿病鼠较正常鼠的视网膜(P〈0.01)和虹膜(P〈0.05)的血管渗透性增加;糖尿病鼠血管抑素注射眼与对侧PBS注射眼相比,视网膜(P〈0.01)和虹膜(P〈0.05)血管渗透性降低;正常鼠注射血管抑素眼与对侧注射PBS眼相比,视网膜和虹膜血管渗透性无明显改变(P〉0.05)Western blot显示血管抑素显著降低了糖尿病鼠视网膜的VEGF水平,但对正常鼠无影响。结论 血管抑素可明显降低糖尿病鼠视网膜、虹膜血管渗透性,但对正常鼠影响不明显。血管抑素可下调糖尿病鼠视网膜VEGF的表达从而阻断其血管渗漏。因此预测血管抑素对糖尿病黄斑水肿、黄斑囊样水肿、葡萄膜炎等血管渗漏性疾病可能具有潜在的治疗价值。 | 司马晶 Ma Jianxing 郭疆 Zhang Sarah X | 2007 | 中国实用眼科杂志2007，25，9： | 3 |
| 2 | Arylsulfatase activity of soil microbial biomass along a Mediterranean-arid transect 显示文摘 | Li X Z Sarah P | 2003 | Soil Biology and Biochemistry2003，35，7： | 1 |
| 3 | Suppression of corneal neovascularization by PEDF release from human amniotic membranes invest ophthalmol显示文摘 | Chunkui S Jing S Sarah X | 2004 | Vis Sci2004，45，6： | 1 |
| 4 | Enzyme activities along a climatic transect in the Judean desert显示文摘 | Li X Sarah P | 2003 | Catena2003，53，： | 1 |
| 5 | Manipulation of allergen-induced airway remodeling by treatment with anti-TGF-β antibody:Effect on the Smad signaling pathway显示文摘 | Sarah JM Georgina X Clare ML | 2005 | J Immunol2005，174，： | 1 |
| 6 | Enzyme activities along a climatic transect in the Judean Desert显示文摘 | Sarah P | 2003 | Catena2003，53，： | 1 |
| 7 | Regulation of abscisic acid- induced stomatal closure and anion channels by guard cell AAPK kinase显示文摘 | Li J X Xi Q W Mark B Sarah M | 2000 | Science2000，287，： | 1 |
| 8 | Ginkgolide A-gold nanopartieles inhibit vascu- lar smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model显示文摘 | SARAH M WEAKLEY M D WANG X W | 2011 | Journal of Surgical Research2011，171，1： | 1 |
| 9 | Cytokine-modified Mycobacterium smegmatis as a Novel anticancer immunotherapy显示文摘 | Sarah L Y Michaei M Zhu X W | 2004 | Int J Cancer2004，112，： | 1 |
| 10 | Arylsulfatase activity of soil microbial biomass along a Mediterranean arid transect 显示文摘 | Li X Z Sarah P | 2003 | Soil Biology & Biochemistry2003，35，7： | 1 |
| 11 | Effects of sulfur dioxide and polyvinylpolypyrdfidone on the flavor stability of beer as measured by sensory and chemial analysis显示文摘 | SARAH E B JEAN X G CHARLES W B | 2003 | J Amerian Society of Brewing Chemists2003，61，3： | 1 |
| 12 | Bioavailahility of Cr( Ⅲ ) and Cr( Ⅵ ) to Marine Mussels from Solute and Particulate Pathways 显示文摘 | Wen X W Sarah B G Nicholas S F | 1997 | Environmental Science and Technology1997，31，2： | 1 |
| 13 | Sliding mode control for time-varying delayed systems based on a reduced order observer 显示文摘 | YANA X SARAH K EDWARD S C | 2010 | Automatica2010，46，8： | 1 |
| 14 | Enzyme activities along a climatic transect in the Juden Desert显示文摘 | LI X SARAH P | 2003 | Catena2003，53，： | 1 |
| 15 | Hypoxia or nutrientrestriction during pregnancy in rats leads to progressive cardiac remodeling and impairs postischemic recovery in adult male offspring 显示文摘 | Yi X Sarah J W Darryl O' Brien | 2006 | FASEB J2006，20，8： | 1 |
| 16 | Suppression of Corneal Neovescularization by PEDF Release from Human Amniotic Membranes显示文摘 | Chunkui Shao Jing Sima Sarah X | 2004 | Invest Ophthalmol Vis Sci2004，45，： | 1 |
| 17 | Saluta- ry effect of pigment epithelium - derived factor on diabeticnephropathy 显示文摘 | Joshua J Wang Sarah X Zhang Robert Mott etal | 2006 | Diabetes2006，55，6： | 1 |
| 18 | Structural charac-teristics of polypyrrole(PPy) -coated polycaprolactam( PA 6) fiber composites prepared by chemical vapor deposition 显示文摘 | Xiao C F Tao X M Leung Sarah M Y | 2006 | Polym Int2006，55，11： | 1 |
| 19 | Arylsulfatase activity of soil microbial biomass along a Mediterranean-arid transect显示文摘 | Li X Z Sarah P | | 0，，07： | 1 |
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