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1篇 您的检索式：作者名="Santosh Ghule"

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		题名	作者	年代	出处	被引量
	1	马蹄花叶提取物在雄性白化病小鼠体内的抗炎作用(英文)显示文摘AIM:To study the in vivo anti-inflammatory activity of Tabernaemontana divaricata leaf extract on male albino mice.METHODS:Aqueous decoction and methanol leaf extracts were tested for their ability to reduce croton oil-induced edema in the mouse ear after topical application.The methanol leaf extract dose-dependently inhibited the croton oil-induced ear edema in mice(ID50<500μg·cm 2).A bioassay-guided liquid–liquid fractionation of this methanol extract gave four active fractions:water insoluble(F1),hexane(F2),ethyl acetate(F3)and water(F4).RESULTS:The hexane fraction showed a very high activity(42.1%inhibition at0.7μg·cm 2)as compared to the control.The other fractions were less active(F1:56.1%at 506.2μg·cm-2;F3:57.3%at 289.3μg·cm 2;and F4:31.9%for 203.8μg·cm 2)while indomethacin gave 48.8%of inhibition at 90μg·cm 2.The activity of F1 and F3 may be at least in part explained by the presence of anti-inflammatory flavonoids,while the activity was not correlated to the tannin contents.No compounds were detected in the most active F2 fraction.CONCLUSIONS:The results give a rational support to the traditional use of T.divaricata in tropical India as anti-inflammatory agent.	Sachin Jain Praveen Sharma Santosh Ghule Ankit Jain Nitesh Jain	2013	中国天然药物2013，11，5：	2

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