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| 1 | Magnetic resonance imaging:A new tool for diagnosis of acute ischemic colitis?显示文摘AIM:To define the evolution of ischemic lesions with 7T magnetic resonance imaging(7T-MRI)in an animal model of acute colonic ischemia.METHODS:Adult Sprague-Dawley rats were divided into two groups.GroupⅠ underwent inferior mesenteric artery(IMA)ligation followed by macroscopic observations and histological analysis.In groupⅡ,7T-MRI was performed before and after IMA ligation and followed by histological analysis.RESULTS:Morphological alterations started to develop 1 h after IMA ligation,when pale areas became evident in the splenic flexure mesentery and progressively worsened up to 8 h thereafter,when the mesentery was less pale,and the splenic flexure loop appeared very dark.The 7T-MRI results reflected these alterations,showing a hyperintense signal in both the intraperitoneal space and the colonic loop wall 1 h after IMA ligation;the latter progressively increased to demonstrate a reduction in the colonic loop lumen at 6 h.Eight hours after IMA ligation,MRI showed a persistent colonic mural hyperintensity associated with a reduction in peritoneal free fluid.The 7T-MRI findings were correlated with histological alterations,varying from an attenuated epithelium with glandular apex lesions at 1 h to coagulative necrosis and loss of the surface epithelium detected 8 h after IMA ligation.CONCLUSION:MRI may be used as a substitute for invasive procedures in diagnosing and grading acute ischemic colitis,allowing for the early identification of pathological findings. | Francesca Iacobellis Daniela Berritto Francesco Somma Carlo Cavaliere Marco Corona Santolo Cozzolino Franco Fulciniti Salvatore Cappabianca Antonio Rotondo Roberto Grassi | 2012 | World Journal of Gastroenterology2012，18，13： | 7 |
| 2 | Acute arterial mesenteric ischemia and reperfusion:Macroscopic and MRI findings, preliminary report显示文摘AIM:To explore the physiopathology and magnetic resonance imaging(MRI)findings in an animal model of acute arterial mesenteric ischemia(AAMI)with and without reperfusion.METHODS:In this study,8 adult Sprague-Dawley rats underwent superior mesenteric artery(SMA)ligation and were then randomly divided in two groups of 4.In groupⅠ,the ischemia was maintained for 8 h.In groupⅡ,1-h after SMA occlusion,the ligation was removed by cutting the thread fixed on the back of the animal,and reperfusion was monitored for 8 h.MRI was performed using a 7-T system.RESULTS:We found that,in the case of AAMI without reperfusion,spastic reflex ileus,hypotonic reflex ileus,free abdominal fluid and bowel wall thinning are present from the second hour,and bowel wall hyperintensity in T2-W sequences are present from the fourth hour.The reperfusion model shows the presence of early bowel wall hyperintensity in T2-W sequences after 1 h and bowel wall thickening from the second hour.CONCLUSION:Our study has shown that MRI can assess pathological changes that occur in the small bowel and distinguish between the presence and absence of reperfusion after induced acute arterial ischemia. | Luca Saba Daniela Berritto Francesca Iacobellis Mariano Scaglione Sigismondo Castaldo Santolo Cozzolino Maria Antonietta Mazzei Veronica Di Mizio Roberto Grassi | 2013 | World Journal of Gastroenterology2013，19，40： | 5 |
| 3 | Optimizing treatment of metastatic colorectal cancer patients with anti-EGFR antibodies: overcoming the mechanisms of cancer cell resistance显示文摘 | Teresa Troiani Silvia Zappavigna Erika Martinelli Santolo R. Addeo Paola Stiuso Fortunato Ciardiello Michele Caraglia | 2013 | Expert Opinion on Biological Therapy2013，，2： | 2 |
| 4 | Association of interleukin-lbeta and interleukin-1 receptor antagonist polymorphisms with bacterial vaginosis in non-pregnant Italian women 显示文摘 | Cauci S Di Santolo M Casabellata G | 2007 | Mol Hum Reprod2007，13，： | 1 |
| 5 | Obstetric risk factors for periventricular leukomalacia among preterm infants 显示文摘 | Spinillo A Capuzzo E Stronati M Ometto A De Santolo A Acciano S | 1998 | Br J Obstet Gynaecol1998，105，8： | 1 |
| 6 | Association of recreational physical activity with homocysteine,folate and lipid markers in young women显示文摘 | Di Santolo M Banfi G Stel G | 2009 | Eur J Appl Physiol2009，105，1： | 1 |
| 7 | Anemia and iron status in young fertile non-professional female athletes显示文摘 | Di Santolo M Stel G Banff G | 2008 | Eur J Appl Physiol2008，102，： | 1 |
| 8 | Some observations of the prediction of the dynamic parameters of debris flows in pyroclastic deposits in the campania region of Italy 显示文摘 | Di Santolo A S Evangelists A | 2009 | Nat Hazards2009，50，： | 1 |
| 9 | Evaluation of pseudostatic active earth pressure coefficient of cantilever retaining walls 显示文摘 | EVANGELISTA A SANTOLO A S SIMONELLI A L | 2010 | Soil Dynamics and Earthquake Engineering2010，30，11： | 1 |
| 10 | Anemia and iron status in young fertile non-professional female athletes 显示文摘 | Di Santolo M Stel G Banff G | 2008 | Eur J Appl Physiol2008，102，6： | 1 |
| 11 | Evaluation of pseudostatic active earth pressure coefficient of cantilever retaining walls显示文摘 | EVANGELISTA A SANTOLO A S D SIMONELLI A L | 2010 | Soil Dynamics and Earthquake Engineering2010，30，11： | 1 |
| 12 | Dynamic active earth pressure on cantilever retaining walls显示文摘 | SANTOLO A S D EVANGELISTA A | 2011 | Computers and Geotechnics2011，38，8： | 1 |
| 13 | Anemia and iron status in young fertile non-professional female athletes显示文摘 | Di Santolo M Stel G Banfi G | | 0，，06： | 1 |
| 14 | Colonic perforation by a transmural and transvalvular migrated retained sponge:Multi-detector computed tomography findings显示文摘Transmural migrated retained sponges usually impact at the level of the ileo-cecal valve leading to a small bowel obstruction.Once passed through the ileo-cecal valve,a retained sponge can be propelled forward by peristaltic activity and eliminated with feces.We report the case of a 52-year-old female with a past surgical history and recurrent episodes of abdominal pain and constipation.On physical examination,a generalized resistance was observed with tenderness in the right flank.Contrast-enhanced multi-detector computed tomography findings were consistent with a perforated right colonic diverticulitis with several out-pouchings at the level of the ascending colon and evidence of free air in the right parieto-colic gutter along with an air-fluid collection within the mesentery.In addition,a ring-shaped hyperdense intraluminal material was also noted.At surgery,the ascending colon appeared irregularly thickened and folded with a focal wall interruption and a peri-visceral abscess at the level of the hepatic flexure,but no diverticula were found.A right hemi-colectomy was performed and on dissection of the surgical specimen a retained laparotomy sponge was found in the bowel lumen. | Luigi Camera Marco Sagnelli Paolo Guadagno Pier Paolo Mainenti Teresa Marra Maria Scotto di Santolo Landino Fei Marco Salvatore | 2014 | World Journal of Gastroenterology2014，20，15： | 0 |
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