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| 1 | Actin,more than just a housekeeping protein at the scene of fertilization显示文摘Since the first demonstration of sperm entry into the fertilized eggs of Mediterranean sea urchin Paracentrotus lividus by Hertwig(1876),enormous progress and insights have been made on this topic.However,the precise molecular mechanisms underlying fertilization are largely unknown.The two most dramatic changes taking place in the zygote immediately after fertilization are:(i) a sharp increase of intracellular Ca2+ that initiates at the sperm interaction site and traverses the egg cytoplasm as a wave,and(ii) the concomitant dynamic rearrangement of the actin cytoskeleton.Traditionally,this has been studied most extensively in the sea urchin eggs,but another echinoderm,starfish,whose eggs are much bigger and transparent,has facilitated experimental approaches using microinjection and fluorescent imaging methodologies.Thus in starfish,it has been shown that the sperm-induced Ca2+ increase in the fertilized egg can be recapitulated by several Ca2+ -evoking second messengers,namely inositol 1,4,5-trisphosphate(InsP3) ,cyclic ADP-ribose(cADPr) and nicotinic acid adenine dinucleotide phosphate(NAADP) ,which may play distinct roles in the generation and propagation of the Ca2+ waves.Interestingly,it has also been found that the dynamic rearrangement of the actin cytoskeleton in the fertilized eggs plays pivotal roles in guiding monospermic sperm entry and in the fine modulation of the intracellular Ca2+ signaling.As it is well known that Ca2+ regulates the structure of the actin cytoskeleton,our finding that Ca2+ signaling can be reciprocally affected by the state of the actin cytoskeleton raises an intriguing possibility that actin and Ca2+ signaling may form a'positive feedback loop'that accelerates the downstream events of fertilization.Perturbation of the cortical actin networks also inhibits cortical granules exocytosis.Polymerizing actin bundles also compose the'acrosome process,'a tubular structure protruding from the head of fertilizing sperm. Hence,actin,which is one of the most strictly conserved proteins in eukaryotes,modulates almost all major aspects of fertilization. | Luigia SANTELLA Jong T.CHUN | 2011 | Science China(Life Sciences)2011，54，8： | 11 |
| 2 | 一种在表面形成Al_2O_3膜的新型耐热奥氏体不锈钢显示文摘一类以在材料表面形成Al2O3膜的奥氏体不锈钢(AFA)的开发正如火如荼地在全球展开。这类合金与传统的、在其表面形成Cr2O3膜的不锈钢相比,在不牺牲其成本、蠕变抗力和可焊性等其它性能的同时具有更高的使用温度和更好的耐环境侵蚀能力。作者简要介绍了该合金的开发方法和其抗氧化和蠕变抗力方面的数据。 | BRADY MP YAMAMOTO Y MAZIASZ PJ SANTELLA ML 韦习成 | 2008 | 自然杂志2008，30，4： | 10 |
| 3 | Association between polymorphisms of APE1 and OGG1 and risk of colorectal cancer in Taiwan显示文摘AIM: To evaluate the effects of OGG1(Ser326Cys, 11657A/G, and Arg154His) and APE1(Asp148Glu, and T-656G) polymorphisms on colorectal cancer(CRC) risk.METHODS: We enrolled 727 cases newly diagnosed with colorectal adenocarcinoma and 736 age- and sex-matched healthy controls from a medical center in Taiwan. Genomic DNA isolated from the buffy coat was used for genotyping through polymerase chain reaction. Unconditional logistic regressions were used for calculating ORs and 95%CIs to determine the association between the genetic polymorphisms and CRC risk. Haplotype frequencies were estimated using PHASE software. Moreover, stratification analyses onthe basis of sex, age at diagnosis, and tumor subsite and stage were performed.RESULTS: The CRC risk was higher in patients with the OGG1 326Ser/Cys + Cys/Cys genotype(OR = 1.38, 95%CI: 1.03-1.85, P = 0.030), particularly high in patients with stage Ⅲ + Ⅳ cancer(OR = 1.48, 95%CI: 1.03-2.13) compared with patients with the Ser/Ser genotype. In addition, OGG1 11657 G allele carriers had a 41% reduced CRC risk among stage 0-Ⅱ patients(OR = 0.59, 95%CI: 0.35-0.98). The CRC risk was significantly higher among females with the APE1 Glu allele(OR = 1.41, 95%CI: 1.02-1.96). The APE1 148Glu/-656 G haplotype was also associated with a significant CRC risk in females(OR = 1.36, 95%CI: 1.03-1.78).CONCLUSION: OGG1 and APE1 polymorphisms are associated with stage- and sex-specific risk of CRC in the Taiwan Residents population. | Ching-Yu Lai Ling-Ling Hsieh Reiping Tang Regina M Santella Chung Rong Chang-Chieh Chih-Ching Yeh | 2016 | World Journal of Gastroenterology2016，22，12： | 7 |
| 4 | Global hypomethylation in hepatocellular carcinoma and its relationship to aflatoxin B_1 exposure显示文摘AIM:To determine global DNA methylation in paired hepatocellular carcinoma(HCC) samples using several different assays and explore the correlations between hypomethylation and clinical parameters and biomarkers,including that of aflatoxin B 1 exposure.METHODS:Using the radio labeled methyl acceptance assay as a measure of global hypomethylation,as well as two repetitive elements,including satellite 2(Sat2) by MethyLight and long interspersed nucleotide elements(LINE1),by pyrosequencing.RESULTS:By all three assays,mean methylation levels in tumor tissues were significantly lower than that in adjacent tissues.Methyl acceptance assay log(mean ± SD) disintegrations/min/ng DNA are 70.0 ± 54.8 and 32.4 ± 15.6,respectively,P = 0.040;percent methylation of Sat2 42.2 ± 55.1 and 117.9 ± 88.8,respectively,P < 0.0001 and percent methylation LINE1 48.6 ± 14.8 and 71.7 ± 1.4,respectively,P < 0.0001.Aflatoxin B 1 albumin(AFB 1-Alb) adducts,a measure of exposure to this dietary carcinogen,were inversely correlated with LINE1 methylation(r =-0.36,P = 0.034).CONCLUSION:Consistent hypomethylation in tumor compared to adjacent tissue was found by the three different methods.AFB 1 exposure is associated with DNA global hypomethylation,suggesting that chemical carcinogens may influence epigenetic changes in humans. | Hulya Yazici Ming-Whei Yu Po-Huang Lee Regina M Santella | 2012 | World Journal of Hepatology2012，4，5： | 5 |
| 5 | 影响三地居民黄曲霉毒素B_1-白蛋白加合物的相关因素分析显示文摘[目的]分析影响存在肝癌发病率梯度的三地居民个体黄曲霉毒素生物效应的相关因素。[方法]对广西扶挼两个自然村农民、南宁和四川成都城市居民采用酶联免疫法检测血浆黄曲霉毒素B1-白蛋白加合物(AFB1-AlbuminAdducts,AAA)水平、肝炎病毒(hepatitisvirus,HV)标志物(HBV两对半,HCV、HDV、HEV和HGV抗体)及肝功能。[结果]扶挼47.2%(42/89)的居民至少1种HV感染标志物阳性;南宁和成都分别为15.8%(31/196)和22.7%(27/119)。Log(AAA)水平(n,x±s)为扶挼(89,2.44±0.16)和南宁(196,2.45±0.15)均高于成都(118,2.20±0.24),(P=0.000);但扶挼与南宁间差别无显著性(P=0.859)。南宁(P=0.023)、成都(P=0.026)两地男性AAA水平均高于女性。扶挼和成都两地HV感染者AAA水平均高于非感染者(P分别为0.447和0.041)。HV(-)组中,AAA水平与年龄(r=-0.199,P=0.000)和BMI(r=-0.158,P=0.006)负相关。HV(+)组AAA分别与白蛋白(P=0.000)、球蛋白(P=0.012)和天冬氨酸转氨酶(P=0.052)相关,而HV(-)组AAA分别与直接胆红素、间接胆红素、白蛋白、γ-谷氨酰转肽酶、总胆汁酸和碱性磷酸酶相关(P<0.05)。[结论]AFB1暴露的生物效应可能受肝炎病毒感染、性别、年龄和代谢等因素的影响。AAA与肝功能指标的相关性提示AFB1对肝脏实质或胆道细胞的损害作用。 | 彭涛 刘志明 刘唐威 黎乐群 秦雪 彭民浩 李佳荃 严律南 梁任祥 韦忠亮 Han-Ming Shen Ong Choon Nam LianWen Wang Qiao Wang Regina M Santella | 2005 | 环境与职业医学2005，22，3： | 3 |
| 6 | Blood DNA methylation markers in prospectively identifiedhepatocellular carcinoma cases and controls from Taiwan显示文摘AIM: To determine if gene-specific DNA methylation in prospectively collected blood samples is associated with later development of hepatocellular carcinoma(HCC).METHODS: Comparing genome-wide DNA methylation profiles using Illumina Human methylation 450 K arrays, we previously identified a list of loci that were differentially methylated between tumor and adjacent nontumor tissues. To examine if dysregulation of DNAmethylation patterns observed in tumor tissues can be detected in white blood cell(WBC) DNA, we conducted a prospective case-control study nested within a community-based cancer screening cohort in Taiwan with 16 years of follow up. We measured methylation levels in ninety-six loci that were aberrant in DNA methylation in HCC tumor tissues compared to adjacent tissues. Baseline WBC DNA from 159 HCC cases and 312 matched controls were bisulfite treated and assayed by Illumina Bead Array. We used the χ2 test for categorical variables and student's t-test for continuous variables to assess the difference in selected characteristics between cases and controls. To estimate associations with HCC risk, we used conditional logistic regression models stratified on the matching factors to calculate odds ratios(OR) and 95%CI. RESULTS: We found that high methylation level in cg10272601 in WNK2 was associated with increased risk of HCC, with an OR of 1.91(95%CI: 1.27-2.86). High methylation levels in both cg12680131 in TPO and cg22511877 in MYT1 L, however, were associated with decreased risk. The ORs(95%CI) were 0.59(0.39-0.87) and 0.50(0.33-0.77), respectively, for those with methylation levels of cg12680131 and cg22511877 above the median compared with those with levels below the median. These associations were still statistically significant in multivariable conditional logistic regression models after adjusting for hepatitis B virus infection and alcohol consumption. CONCLUSION: These findings support the measurement of methylation markers in WBC DNA as biomarkers of HCC susceptibility but should be replicated in additional prospective studies. | Hui-Chen Wu Jing Shen Hwai-I Yang Wei-Yann Tsai Chien-Jen Chen Regina M Santella | 2016 | World Journal of Hepatology2016，8，5： | 2 |
| 7 | Immunohistochemical detection of alatoxin B1 -DNA adducts and hepatitis B virus antigens in hepatocellular carcinoma and nontumorous liver tissue 显示文摘 | Santella RM Zhang YJ Chen CJ | 1993 | Environ Health Perspect1993，99，： | 1 |
| 8 | PAH-DNA adducts, cigarette smoking, GST polymorphisms, and breast cancer risk显示文摘 | McCarty K M Santella R M Steck S E | 2009 | Environ Health Perspect2009，117，4： | 1 |
| 9 | 查看详情显示文摘 | Mooney LV Bell FG Santella RM | | 0，，： | 1 |
| 10 | Dysregulation of circulating microRNAs and prediction of aggressive prostate cancer显示文摘 | Jing Shen Gregory W. Hruby James M. McKiernan Irina Gurvich Michael Jeffrey Lipsky Mitchell C. Benson Regina M. Santella | 2012 | Prostate2012，，13： | 1 |
| 11 | Association between arsenic exposure from drinking water and plasma levels of soluble cell adhesion molecules显示文摘 | Chen Y Santella RM Kibriya MG | 2007 | Environ Health Perspect2007，115，10： | 1 |
| 12 | Effects of friction stir processing on mechanical properties of the cast aluminum alloys A319 and A356 显示文摘 | SANTELLA M L ENGSTROM T STORJOHANN D | 2005 | Scripta Materialia2005，53，： | 1 |
| 13 | Prevention of obesity -linked renal disease: age - dependent effects of dietary food re- striction 显示文摘 | Maddox DA Alavi FK Santella RN | 2002 | Kidney Int2002，62，1： | 1 |
| 14 | Effectof alloying additions on phase equilibria and creep resistance of alumina-forming austenitic stainless steels 显示文摘 | YAMAMOTO Y SANTELLA ML BRADY MP | 2009 | Metallurgical and Materials Transactions A2009，8，40： | 1 |
| 15 | The Develop- ment of Alumina-Forming Austenitic Stainless Steels for High temperature Structural Use显示文摘 | Brady M P Yamamoto Y Santella M L | 2008 | JOM2008，60，7： | 1 |
| 16 | Approaches to DNA/RNA Extraction and whole genome amplification 显示文摘 | Santella RM | 2006 | Cancer Epidem Biomar2006，15，9： | 1 |
| 17 | A frequency and symbol S \synchronization system for OFDM signals显示文摘 | Santella Giovanni | 2000 | IEEE2000，49，1： | 1 |
| 18 | Thermodynamics of Ti in Ag-Cu alloys 显示文摘 | PAK J J SANTELLA M L FRUEHAN R J | 1990 | Metallurgical Transaction B1990，21，： | 1 |
| 19 | Membrane reactor for water gas shift reaction显示文摘 | Basile A Criscuoli A Santella F | 1996 | Gas Sep Purif1996，10，4： | 1 |
| 20 | Polycyclic aromatic hydrocarbon-DNA adducts in human sperm as a marker of DNA damage and infertility显示文摘 | Gaspari L Chang SS Santella RM | | 0，，02： | 1 |
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