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| 1 | Successful outpatient management of acute upper gastrointestinal hemorrhage:use of practice guidelines in a large patient series显示文摘Successfuloutpatientmanagementofacuteuppergastrointestinalhemorhage:useofpracticeguidelinesinalargepatientseriesGeorgeF.Longs... | George F. Longstreth, MD, Steven P. Feitelberg, MD Department of Medicine Kaiser Permanente Health care Pragram, San Diego, California | 1998 | World Journal of Gastroenterology1998，4，3： | 8 |
| 2 | Costimulation of resting B lymphocytes alters the IL-4-activated IRS2 signaling pathway in a STAT6 independent manner: implications for cell survival and proliferation显示文摘IL-4 is an important B cell survival and growth factor. IL-4 induced the tyrosine phosphorylation of IRS2 in resting B lymphocytes and in LPS- or CD40L-activated blasts. Phosphorylated IRS2 coprecipitated with the p85 subunit of PI 3’ kinase in both resting and activated cells. By contrast, association of phosphorylated IRS2 with GRB2 was not detected in resting B cells after IL-4 treatment although both proteins were expressed. However, IL-4 induced association of IRS2 with GRB2 in B cell blasts. The pattern of IL-4- induced recruitment of p85 and GRB2 to IRS2 observed in B cells derived from STAT6 null mice was identical to that observed for normal mice. While IL-4 alone does not induce activation of MEK, a MEKI inhibitor suppressed the IL-4-induced proliferative response of LPS-activated B cell blasts. These results demonstrate that costimulation of splenic B cells alters IL-4-induced signal transduction independent of STAT6 leading to proliferation. Furthermore, proliferation induced by IL-4 in LPS-activated blasts is dependent upon the MAP kinase pathway. | ZAMORANO JOSE,Unidad de Investigacion, Hospital San Pedro de Alcantara, Avda Millan Astray, 10003 Caceres ANN E KELLY, JONATHAN AUSTRIAN, HELEN Y WANG, ACHSAH D KEEGAN (Department of Immunology, Jerome Holland Labs, American Red Cross, Rockville, MD, USA | 2001 | Cell Research2001，11，1： | 4 |
| 3 | Caerulein-induced acute pancreatitis inhibits protein synthesis through effects on eIF2B and eIF4F显示文摘 | Sans MD DiMagno MJ DAlecy LG | 2003 | Am J Physiol Gastrointest Liver Physiol2003，285，3： | 1 |
| 4 | Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells显示文摘 | Williams JA Sans MD Tashiro M | 2002 | Pharmacol Toxicol2002，91，6： | 1 |
| 5 | Retinal toxicity of intravitreal tissue plasminogen activator显示文摘 | San N Chen MD Cheng Y | 2003 | Ophthalmology2003，110，4： | 1 |
| 6 | Skeletal maturation determined by cervical vertebrae development 显示文摘 | San Roman P Palma JC Oteo MD | 2002 | Eur J Orthod2002，24，3： | 1 |
| 7 | Radiation therapy alone in elderly with early stage non-small cell lung cancer 显示文摘 | San JoseS Amaiz MD Lucas A | 2006 | Lung Cancer2006，52，2： | 1 |
| 8 | Skeletal maturation determined by cervical vertebrae development显示文摘 | San Roman P Palma JC Oteo MD | 2002 | Eur J Orthod2002，24，3： | 1 |
| 9 | Transmural ele-ctrical stimulation in the reticular groove of adult cattle显示文摘 | San Andrés MD Vinagre E González F | 1993 | Rev Esp Fisiol1993，49，4： | 1 |
| 10 | Radiation therapy alone in elderly with early stage non-small cell lung cancer显示文摘 | San Jose S Arnaiz MD Lucas A | 2006 | Lung Cancer2006，52，2： | 1 |
| 11 | Radiation therapy alone in elderly with early stage non-small cell lung cancer显示文摘 | San José S Arnaiz MD Lucas A | 2006 | Lung Cancer2006，52，2： | 1 |
| 12 | Quantitative organellar pro- teomics analysis of rough endoplasmic reticulum from normal and acute pancreatitis rat pancreas显示文摘 | Chen X Sans MD Strahler JR | 2010 | J Proteome Res2010，9，： | 1 |
| 13 | Autonomic nervous system and sudden cardiac death显示文摘 | Barron HV Lesh MD San Francisco F | 1996 | JACC1996，27，4： | 1 |
| 14 | Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis显示文摘 | Kubisch CH Sans MD Arumugam T | | 0，，： | 1 |
| 15 | Autonomoc nervous system and sudden cardiac death显示文摘 | Barrom HV Ieadh MD San Francisco F | 1996 | JACC1996，27，： | 1 |
| 16 | Autonomic nervous system and redden cardiac death显示文摘 | Barron HV Lesh MD San Francisco F | 1996 | J Am Coll Caroliol1996，27，： | 1 |
| 17 | Skeletal maturation detelmined by cervical vertebrae development显示文摘 | San Roman P Palma JC Oteo MD | 2002 | Eur J Orthod2002，24，3： | 1 |
| 18 | Molecular characterization of the endoplasmic reticulum:insights from proteomic studies显示文摘 | Chen X Karnovsky A Sans MD | 2010 | Proteomics2010，10，22： | 1 |
| 19 | Cholecystokinin activates a variety of intracellular signal transduction mechanisms in rodent pancreatic acinar cells显示文摘 | Williams JA Sans MD Tashiro M | 2002 | Pharmacol Toxicol2002，91，6： | 1 |
| 20 | Molecular characterization of the endoplasmic reticulum: insights from proteomic studies 显示文摘 | Chen X Karnovsky A Sans MD | 2010 | Proteomics2010，10，22： | 1 |
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