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| 1 | Isolation of the mucilages from Hibiscus rosasinensis linn.and Okra(Abelmoschus esculentus linn.) and studies of the binding effects of the mucilages显示文摘Objective:To isolate and evaluate comparatively the binding efficacy of the mucilages obtained from the plants of Hibiscus rosasinensis and Okra(Abelmoschus esculentus).Methods:Extraction of mucilages from the leaves of Hibiscus and pods of Okra(Ladies finger) was carried out by a cold maceration process.The extracted mucilages were subjected to various physicochemical properties for its suitability as an excipient in the formulation of tablet dosage form.Different concentrations(10,8,5,2 and 1%w/v) of binder solutions of Hibiscus and Okra were used for the formulation of tablets and the formulated tablets were evaluated by studying the standard parameters like diameter,thickness,weight variation,hardness,friability,disintegration and in vitro dissolution.Stability studies of the formulated tablets were conducted for four weeks. Results:The formulated tablets prepared using the mucilages of both Hibiscus and Okra had good appearance.The in vitro drug release profile of the tablets prepared using Okra mucilage had an optimum of 90%at a mucilage concentration of 1%w/v concentration mucilage itself within 4 h.Conclusions:According to the observations,the lower concentration levels of Okra can be used as an alternative binder to starch.The higher concentration levels of Okra mucilage show a slow and sustained release,and can be considered as an alternative natural excipient in the modified drug delivery systems.At the same time,the above natural excipient of Hibiscus mucilage could be used as a platform for prolonged release if its binder concentrations are increased. | Ameena K Dilip C Saraswathi R Krishnan PN Sankar C Simi SP | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 8 |
| 2 | Anti-inflammatory activity of the leaf extacts of Gendarussa vulgaris Nees显示文摘Objective:To evaluate the anti-inflammatory property of the leaf exacts of Gendarussa vulgaris(G.vulgarix) Nees.Methods:G.vulgarix Nees of the family Apocynaceae is a medium sized tree grown in semishade or no shade and is common in the Ernad and Nilambur taluks of Kerala. Various parts of this plant have been used in the treatment of ulcers,sores,inflammation, dyspepsia,healing of wounds,etc.The present study aimed at the evaluation of anti-inflammatory property of the aqueous and alcoholic extracts of the leaves by both in vitro and in vivo methods. In vitro method was estimated by human red blood cell membrane stabilisation(HRBC) method and in vivo method was estimated on the carrageenan induced paw oedima.Results:Both the methods showed significant anti-inflammatory property of the different extracts tested. Conclusions:The alcoholic extract at a concentration of 300 mg/mL showed potent activity on comparing with the standard drug diclofenac sodium. | TK Mohamed Saleem AK Azeem C Dilip C Sankar NV Prasanth R Duraisami | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，2： | 3 |
| 3 | L-asparaginase production by mangrove derived Bacillus cereus MAB5:optimization by response surface methodology显示文摘Objective:To isolate marine bacteria,statistically optimize them for maximum asparaginase production.Methods:In the present study,statistically based experimental designs were applied to maximize the production of L-asparaginase from bacterial strain of Bacillus cereus(B.cereus) MAB5(HQ675025) isolated and identified by 16S rDNA sequencing from mangroves rhizosphere sediment.Results:Plackett-Barman design was used to identify the interactive effect of the eight variables viz.yeast extract,soyabean meal,glucose,magnesium sulphate,KH2PO4,wood chips,aspargine and sodium chloride.All the variables are denoted as numerical factors and investigated at two widely spaced intervals designated as -1(low level) and +1(high level). The effect of individual parameters on L-asparaginase production was calculated.Soyabean meal,aspargine,wood chips and sodium chloride were found to be the significant among eight variables.The maximum amount of L-asparaginase produced(51.54 IU/mL) from the optimized medium containing soyabean meal(6.282 8 g/L),aspargine(5.5 g/L),wood chips(1.383 8 g/L) and NaCl(4.535 4 g/L).Conclusions:The study revealed that,it is useful to produce the maximum amount of L-asparaginase from B.cereus MAB5 for the treatment of various infections and diseases. | Thenmozhi C Sankar R Karuppiah V Sampathkumar P | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 2 |
| 4 | A review on image segmentation techniques显示文摘 | NIKHIL R PAL SANKAR K PAL | 1993 | Pattern Recognition1993，26，9： | 1 |
| 5 | Automatic computer analysis of transients in EEG显示文摘 | Sankar R Natour J | 1992 | Computers in Biology and Medicine1992，22，6： | 1 |
| 6 | Pal. A Review on Image Segmentation Techniques显示文摘 | Nikhil R Pal Sankar K | | 0，，： | 1 |
| 7 | Alpha-tocopherol reduces doxorubicin-induced toxicity in rats--histological and bio- chemical evidences 显示文摘 | Geetha A Sankar R Marar T | 1990 | Indian J Physiol Pharmaeol1990，34，： | 1 |
| 8 | Preparation andpartial characterization of collagen sheet from fish scales 显示文摘 | SANKAR S SEKAR S MOHAN R | 2008 | International Journal of Biological Macromolecules2008，42，1： | 1 |
| 9 | Slip Velocities in Pneumatic Transport Part II显示文摘 | Sankar S R Smith T N | 1986 | Powder Technology1986，47，2： | 1 |
| 10 | The pharmacologic basis of antiepileptic drug action显示文摘 | Sankar R | 1999 | Epilepsia1999，40，11： | 1 |
| 11 | Performance of Global Ensemble Forecast Systern(GEFS) during Monsoon 2012显示文摘 | Ashrit R Iyengar G R Sankar S | 2013 | 2013，，： | 1 |
| 12 | Following the formation of y-phase Bi2MoO6 catalyst by in situ XRD/XAS and thermogravimetric techniques显示文摘 | REILLY L M SANKAR G CATLOW C R A | | 0，，1： | 1 |
| 13 | A survey of intrusion detection systems in wireless sensor networks显示文摘 | Butun I Morgera S D Sankar R | 2014 | IEEE Communications Surveys&Tutorials2014，16，1： | 1 |
| 14 | Molecular sieve catalysts for the regioselective and shape selective oxyfunctionalization of alkanes in air 显示文摘 | Thomas J M Raja R Sankar G | 2001 | Acc Chem Res2001，34，3： | 1 |
| 15 | Adaptive VBR traffic management for higher utilization of ATM networks显示文摘 | CHIRUVOLU G SANKAR R RANGANATHAN N | 1998 | ACM SIGCOMM Computer Communications Review1998，28，3： | 1 |
| 16 | Doxofylline:The next generation methylxanthine显示文摘 | Sankar J Lodha R Kabra SK | 2008 | Indian J Pediatr2008，75，3： | 1 |
| 17 | A review on image segmentation technique显示文摘 | Nikhil R P Sankar K P | 1993 | Pattern Recognition1993，26，9： | 1 |
| 18 | Molecular sieve catalysts for the regioselective and shape se- lective oxyfunctionalization of alkanes in air显示文摘 | THOMAS J M RAJA R SANKAR G | 2001 | Acc Chem Res2001，34，3： | 1 |
| 19 | Sepsis in the newborn显示文摘 | Sankar M J Agarwal R Deorari A K | 2008 | Ind JPediatr2008，75，3： | 1 |
| 20 | Functional proper- ties of Rohu ( Labeo rohita) proteins during iced storage 显示文摘 | Mukund M Dhanya R Sankar T V | 2006 | Food Research International2006，39，8： | 1 |
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