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1篇 您的检索式：作者名="Sandrita Simonyte"

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		题名	作者	年代	出处	被引量
	1	MMP-2 Rs24386(C-->T) gene polymorphism and the phenotype of age-related macular degeneration显示文摘AIM: To examine the MMP-2(-1306 C/T) gene polymorphism and the phenotype characterized by soft and hard drusen of early age-related macular degeneration(AMD) and geographic atrophy of late AMD form.METHODS: The study enrolled 850 investigations(290 AMD patients with soft and hard drusen, 34 with geographic atrophy and a random sample of the population n=526). Early AMD was classified according to the International Classification and Grading System. For geographic atrophy diagnosis the Age-Related Eye Disease Study classification was used. The potential association with single nucleotide polymorphisms on MMP-2 Rs243865 was evaluated for all patients, adjusted for age and sex. The genotyping test of MMP-2 Rs243865(C-->T) was conducted using the real-time polymerase chain reaction method.RESULTS: MMP-2(-1306 C/T) C/C genotype was more frequently detected in AMD patients with hard drusen than the soft drusen or control group(66.43% vs 53.74%, vs 54.94%, P=0.047). Logistic regression analysis showed that the MMP-2(-1306) C/C genotype increased the likelihood to develop hard drusen in AMD patients(OR=1.7, 95% CI: 1.06-2.74; P=0.028). No association between MMP-2(-1306 C/T) gene polymorphism in patients with atrophic AMD and control group was found(54.94%, 37.64%, 7.41% vs 50%, 38.24%, 11.76%; P=0.6).CONCLUSION: The MMP-2 Rs24386(C-->T) polymorphism is found to be associated with the development of hard drusen in patients with AMD.	Rasa Liutkeviciene Vaiva Lesauskaite Giedre Sinkunaite-Marsalkiene Sandrita Simonyte Reda Zemaitiene Loresa Kriauciuniene Dalia Zaliuniene	2017	International Journal of Ophthalmology(English edition)2017，10，9：	0

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