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您的检索式：作者名="Sandra Sefa"
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| 1 | Multiscale morphological analysis of bone microarchitecture around Mg-10Gd implants显示文摘The utilization of biodegradable magnesium(Mg)-based implants for restoration of bone function following trauma represents a transformative approach in orthopaedic application.One such alloy,magnesium-10 weight percent gadolinium(Mg-10Gd),has been specifically developed to address the rapid degradation of Mg while enhancing its mechanical properties to promote bone healing.Previous studies have demonstrated that Mg-10Gd exhibits favorable osseointegration;however,it exhibits distinct ultrastructural adaptation in comparison to conventional implants like titanium(Ti).A crucial aspect that remains unexplored is the impact of Mg-10Gd degradation on the bone microarchitecture.To address this,we employed hierarchical three-dimensional imaging using synchrotron radiation in conjunction with image-based finite element modelling.By using the methods outlined,the vascular porosity,lacunar porosity and the lacunar-canaliculi network(LCN)morphology of bone around Mg-10Gd in comparison to Ti in a rat model from 4 weeks to 20 weeks post-implantation was investigated.Our investigation revealed that within our observation period,the degradation of Mg-10Gd implants was associated with significantly lower(p<0.05)lacunar density in the surrounding bone,compared to Ti.Remarkably,the LCN morphology and the fluid flow analysis did not significantly differ for both implant types.In summary,a more pronounced lower lacunae distribution rather than their morphological changes was detected in the surrounding bone upon the degradation of Mg-10Gd implants.This implies potential disparities in bone remodelling rates when compared to Ti implants.Our findings shed light on the intricate relationship between Mg-10Gd degradation and bone microarchitecture,contributing to a deeper understanding of the implications for successful osseointegration. | Sandra Sefa Jonathan Espiritu Hanna Cwieka Imke Greving Silja Flenner Olga Will Susanne Beuer D.C Florian Wieland Regine Willumeit-Romer Berit Zeller-Plumhoff | 2023 | Bioactive Materials2023，，12： | 0 |
| 2 | Detailing the influence of PEO-coated biodegradable Mg-based implants on the lacuno-canalicular network in sheep bone:A pilot study显示文摘An increasing prevalence of bone-related injuries and aging geriatric populations continue to drive the orthopaedic implant market.A hierarchical analysis of bone remodelling after material implantation is necessary to better understand the relationship between implant and bone.Osteocytes,which are housed and communicate through the lacuno-canalicular network(LCN),are integral to bone health and remodelling processes.Therefore,it is essential to examine the framework of the LCN in response to implant materials or surface treatments.Biodegradable materials offer an alternative solution to permanent implants,which may require revision or removal surgeries.Magnesium alloys have resurfaced as promising materials due to their bone-like properties and safe degradation in vivo.To further tailor their degradation capabilities,surface treatments such as plasma electrolytic oxidation(PEO)have demonstrated to slow degradation.For the first time,the influence of a biodegradable material on the LCN is investigated by means of non-destructive 3D imaging.In this pilot study,we hypothesize noticeable variations in the LCN caused by altered chemical stimuli introduced by the PEO-coating.Utilising synchrotron-based transmission X-ray microscopy,we have characterised morphological LCN differences around uncoated and PEO-coated WE43 screws implanted into sheep bone.Bone specimens were explanted after 4,8,and 12 weeks and regions near the implant surface were prepared for imaging.Findings from this investigation indicate that the slower degradation of PEO-coated WE43 induces healthier lacunar shapes within the LCN.However,the stimuli perceived by the uncoated material with higher degradation rates induces a greater connected LCN better prepared for bone disturbance. | Jonathan Espiritu Sandra Sefa Hanna Cwieka Imke Greving Silja Flenner Regine Willumeit-Römer Jan-Marten Seitz Berit Zeller-Plumhoff | 2023 | Bioactive Materials2023，，8： | 0 |
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