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| 1 | Preservation of sperm of cancer patients: extent of use and pregnancy outcome in a tertiary infertility center显示文摘精子 cryopreservation 是最好的形式为与癌症诊断的男性保证未来生育力。cryopreserved 精子实际上为受精,可得到的富饶治疗选择和这些治疗的成功率被使用到的程度没深入地被调查。谁的 682 个病人的医药记录 cryopreserved 精子房间由于癌症,治疗被分析。七十个这些病人在 20 年的经期(在在 cryopreservation 以后的开始的 4 年以内的大多数) 上为生育力治疗撤退了他们的冻结的精子。不同恶意的精子质量和为在与治疗的类型和恶意的类型的关系的怀孕成就的帮助繁殖治疗(艺术) 的结果被评估。结果证明在我们的单位为富饶治疗从癌症病人使用融化 cryo 的精子的率是 10.3 %。精子优秀索引在恶意的不同类型之间不同,与在阴囊的癌症测量的最差的质量。概念在 184 个艺术周期中的 46 个被完成(25 %) ,并且导致了 36 交货。注射(ICSI ) 方法论产出的 intracytoplasmic 精子的使用显著地更高的怀孕率(37.4 %) 比子宫内的授精(IUI;11.5 %) 并且类似于用这些形式的其它组不肥沃的夫妇。在 vitro,授精(IVF ) 没能生产怀孕。在结论,在癌症病人的 cryopresseved 精子的使用的率是相对低的(10.3 %) 。由 ICSI 的怀孕的成就介绍最好的选择但是当有足够的存储精子样品和足够的质量时, IUI 能被采用。Cryopreservation 是但为癌症病人保存未来生育力潜力和希望的最好的选择。 | Amnon Botchan Shiri Karpol Ofer Lehavi Gedalia Paz Sandra E Kleiman LeahYogev Haim Yavetz Ron Hauser | 2013 | Asian Journal of Andrology2013，15，3： | 4 |
| 2 | Function and regulation of self-reactive marginal zone B cells in autoimmune arthritis显示文摘Polyreactive 天生类型的 B 房间说明在圆周表示自我反应的许多 B 房间。这些 B 房间的不适当的规定可以是位于自体免疫的疾病下面的一个重要因素。这里,我们在导致骨胶原的关节炎(中央情报局) 的开发探索了自我反应的天生的 B 房间的影响,风湿性关节炎的一个鼠标模型。我们显示出那个脾的边缘的地区(MZ ) ,然而并非 B-1 B 房间在 naı 展出自发的 IgM 反应到自体同源的骨胶原 II; ¨ ve 老鼠。在有在完全的 Freund’ 的 heterologous 骨胶原 II 的免疫之上;骨胶原反应的 MZ B 房间很快扩展了的 s 助手,当 B-1 B 房间显示出谦虚反骨胶原回答时。MZ B 房间被像使用费的受体(TLR ) 容易激活 4 并且在 vitro,导致的增长和 cytokine 分泌物的 9-ligands,暗示 B 房间受体和 TLR 的那个双约会可以把有免疫力的反应提升到自我抗原。而且,告知骨胶原的 MZ B 房间显示出在 vivo 在 IgG 反骨胶原抗体的 vitro 和正式就职由血缘的 T 房间增长思考了的重要介绍抗原的能力。在 1 和 2 表明了的补充受体是缺乏的 MZ B 房间增加了增长和 cytokine 生产,当时 Fcγ房间的受体 IIb 缺乏导致增加的 cytokine 生产和抗原表示。在结论,我们的数据在中央情报局作为自体免疫的反应的开始者加亮自我反应的 MZ B 房间,在补充和 Fc 受体在在房间控制自我反应是相关的的地方。 | Anna-Karin E Palm Heike C Friedrich Anja Mezger Maya Salomonsson Linda K Myers Sandra Kleinau | 2015 | Cellular & Molecular Immunology2015，12，4： | 3 |
| 3 | Marginal zone B cells are naturally reactive to collagen type II and are involved in the initiation of the immune response in collagen-induced arthritis显示文摘Antibodies against type II collagen(CII)are essential for development of collagen-induced arthritis(CIA),but how and where the B-cell response to CII is initiated is not fully known.We show here that naive DBA/1 mice display naturally reactive IgM and IgG anti-CII producing B cells prior to immunization.The CII-reactive B cells were observed in the spleen and recognized as marginal zone(MZ)B cells.After CII immunization,CII-specific B cells expanded rapidly in the spleen,in contrast to the lymph nodes,with the initial response derived from MZ B cells and later by follicular(FO)B cells.This was evident despite that the MZ B cells were subject to stringent tolerance mechanisms by having a greater Fc gamma receptor IIb expression than the FO B cells.Further,the MZ B cells migrated to the FO areas upon immunization,possibly providing antigen and activating FO T cells and subsequently FO B cells.Thus,around CIA onset increased numbers of IgG anti-CII producing FO B cells was seen in the spleen,which was dominated by IgG2a-and IgG2b-positive cells.These data demonstrate that CII-reactive MZ B cells are present before and expand after CII immunization,suggesting an initiating role of MZ B cells in the development of CIA. | Cecilia Carnrot Kajsa E Prokopec Kristina Rasbo Mikael CI Karlsson Sandra Kleinau | 2011 | Cellular & Molecular Immunology2011，8，4： | 3 |
| 4 | Hematopoietic AMPK [Beta]1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity显示文摘 | Galic Sandra Fullerton Morgan D Schertzer Jonathan D Sikkema Sarah Marcinko Katarina Walkley Carl R Izon David Honeyman Jane Chen Zhi-Ping van Denderen Bryce J Kemp Bruce E Steinberg Gregory R | 2011 | Journal of Clinical Investigation2011，，12： | 2 |
| 5 | Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration显示文摘 | Joanna M Wardlaw Eric E Smith Geert J Biessels Charlotte Cordonnier Franz Fazekas Richard Frayne Richard I Lindley John T O’Brien Frederik Barkhof Oscar R Benavente Sandra E Black Carol Brayne Monique Breteler Hugues Chabriat Charles DeCarli Frank-Erik de | 2013 | Lancet Neurology2013，，8： | 2 |
| 6 | Incidence and predictors of glaucoma following surgery for congenital cataract in the first year of life in V ictoria, A ustralia显示文摘 | Jonathan B Ruddle Sandra E Staffieri Jonathan G Crowston Justin C Sherwin David A Mackey | 2013 | Clin Experiment Ophthalmol2013，，7： | 1 |
| 7 | Sulphite and oxida- tive-reductive depolymerization reactions 显示文摘 | Loma A Paterson Sandra E Hill John R | 1997 | Food Chemistry1997，60，2： | 1 |
| 8 | Efficacy of amannan oligosaccharide(Bio-Mos)for improving nursery pigperformance显示文摘 | Miguel J C Sandra L Rodriguez-Zas Pettigrew J E | 2004 | Journal of Swine Health and Production2004，12，6： | 1 |
| 9 | Phycotoxin-related shellfish poisoning; bivalve mollusks are not the only vectors显示文摘 | SHUMWAY SANDRA E | 1995 | Reviews in Fisheries Science1995，3，1： | 1 |
| 10 | Clinical outcome 2 years after in- traeoronary administration of bone marrow-derived progenitor cells in acyte myocardial infarction显示文摘 | B irgit A Andreas R Sandra E | 2010 | Circ Heart Fail2010，3，： | 1 |
| 11 | Antimalarial quinolines and artemisinin inhibit endocytosis in plasmodium falciparum显示文摘 | Heinrich C Donelly A Ursula M Sandra A Joanne E Brandon W | 2004 | Antimicro Agents Chemother2004，48，： | 1 |
| 12 | CHRONIC HEPATITIS C: HEPATIC IRON CONTENT DOES NOT CORRELATE WITH RESPONSE TO ANTIVIRAL THERAPY显示文摘 | Pereira Patricia da Silva Fucuta Silva Ivonete Sandra de Souza E Uehara Silvia Naomi de Oliveira Emori Christini Takemi Lanzoni Valéria Pereira Silva Antonio Eduardo Benedito Ferraz Maria Lucia Gomes | 2009 | Revista do Instituto de Medicina Tropical de S茫o Paulo2009，，6： | 1 |
| 13 | Neprilysin Regulates Pulmonary Artery Smooth Muscle Cell Phenotype Through a Platelet-Derived Growth Factor Receptor–Dependent Mechanism显示文摘 | Vijaya Karoor Masahiko Oka Sandra J. Walchak Louis B. Hersh York E Miller Edward C. Dempsey | 2013 | Hypertension2013，，4： | 1 |
| 14 | Stevens, fabrication of a super-hydrophobic polypropylene membrane by deposition of a porous crystalline polypropylene coating显示文摘 | Julianna A Sandra E Jilska M | 2008 | J Membr Sci2008，318，： | 1 |
| 15 | Osteoblast cell death on methac- rylate polymers involves apoptosis显示文摘 | Julie E Gough Sandra D | 2002 | Biomed Mater Res2002，57，4： | 1 |
| 16 | Towards automated, miniaturized and solvent-free sample preparation methods显示文摘 | David E Van Hoeck E Sandra P | 2007 | Anal Bioanal Chem2007，387，： | 1 |
| 17 | An Abnormal Mitochondrial–Hypoxia Inducible Factor-1α–Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension显示文摘 | Sébastien Bonnet Evangelos D. Michelakis Christopher J. Porter Miguel A. Andrade-Navarro Bernard Thébaud Sandra Bonnet Alois Haromy Gwyneth Harry Rohit Moudgil M Sean McMurtry E Kenneth Weir Stephen L. Archer | 2006 | Circulation2006，，22： | 1 |
| 18 | Sequence determination of the Crimean Congo hemorrhagic fever virus L segment显示文摘 | Kinsella E Sandra GM Grolla A | 2004 | Virology2004，321，： | 1 |
| 19 | Phospholipid asymmetry in LM cell plasma membrane derivatives: polar head group and acyl chain distributions显示文摘 | Sandra A Pagano R E | 1978 | Biochemistry1978，17，2： | 1 |
| 20 | The efficiency of pectinase scouring with agitation to improve cotton fabric wettability 显示文摘 | MICHEH E H L SANDRA K | 2000 | Textile Chem and Colorist & American Dyestuff Reporter2000，，8： | 1 |
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