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| 1 | Protein phosphatases and chromatin modifying complexes in the inflammatory cascade in acute pancreatitis显示文摘Acute pancreatitis is an inflammation of the pancreas that may lead to systemic inflammatory response syndrome and death due to multiple organ failure. Acinar cells, together with leukocytes, trigger the inflammatory cascade in response to local damage of the pancreas. Amplification of the inflammatory cascade requires up-regulation of proinflammatory cytokines and this process is mediated not only by nuclear factor κB but also by chromatinmodifying complexes and chromatin remodeling. Among the different families of histone acetyltransferases, the p300/CBP family seems to be particularly associated with the inflammatory process. cAMP activates gene expression via the cAMP-responsive element (CRE) and the transcription factor CRE-binding protein (CREB). CREB can be phosphorylated and activated by different kinases, such as protein kinase A and MAPK, and then it recruits the histone acetyltransferase co-activator CREB-binding protein (CBP) and its homologue p300. The recruitment of CBP/p300 and changes in the level of histone acetylation are required for transcription activation. Transcriptional repression is also a dynamic and essential mechanism of down-regulation of genes for resolution of inflammation, which seems to be mediated mainly by protein phosphatases (PP1, PP2A and MKP1) and histone deacetylases(HDACs) .Class HDACs are key transcriptional regulators whose activities are controlled via phosphorylationdependent nucleo/cytoplasmic shuttling. PP2A is responsible for dephosphorylation of class HDACs, triggeringnuclear localization and repression of target genes, whereas phosphorylation triggers cytoplasmic localization leading to activation of target genes. The potential benefit from treatment with phosphodiesterase inhibitors and histone deacetylase inhibitors is discussed. | Javier Escobar Javier Pereda Alessandro Arduini Juan Sastre Juan Sandoval Luis Aparisi Gerardo López-Rodas Luis Sabater | 2010 | World Journal of Gastrointestinal Pharmacology and Therapeutics2010，1，3： | 2 |
| 2 | Refractive surgery survey 2001 显示文摘 | Solomon KD Holzer MP Sandoval HP Vargas LG Werner L Vroman DT et ol | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
| 3 | Impairedtubular uptake explains albuminuria in early diabetic nephropathy显示文摘 | RUSSO L M SANDOVAL R M CAMPOS S B | 2009 | J Am Soc Nephrol2009，20，3： | 1 |
| 4 | Pirfenidone effectively reverses experimental liver fibrosis显示文摘 | Garcia L Hernandez I Sandoval A | 2002 | J Hepatol2002，37，： | 1 |
| 5 | Effects of cornoil on glass transition temperatures of cassava starch显示文摘 | L Madrigal A J Sandoval A J M il ller | 2011 | Carbohydrate Polymer2011，85，4： | 1 |
| 6 | Identification of lactic acid bacteria isolated from Genestoso cheese throughout ripening and study of their antimicrobial activity显示文摘 | GONZALEZ L SANDOVAL H SACRISTAN N | 2007 | Food Control2007，18，6： | 1 |
| 7 | Identification of lactic acid bacteria isolated from Genestoso cheese throughout ripening and study of their antimicrobial activity显示文摘 | Gonzalez L Sandoval H Sacristan N | 2007 | Food Control2007，18，： | 1 |
| 8 | Finite size effects in Fe nanowire soli&solid phase transitions: a molecular cly- namics approach 显示文摘 | SANDOVAL L URBASSEK H M | 2009 | Nano Letters2009，9，6： | 1 |
| 9 | A model of early molecular rcgionalization in the chicken embryonic pretectum显示文摘 | Ferran JL Sinchez-Arrones L Sandoval JE | 2007 | J Comp Neurol2007，505，4： | 1 |
| 10 | Serum uricacid and outcome after acute is chemic stroke:PREMIER study显示文摘 | Chiquete E Ruiz Sandoval J I Murillo Bonilla L M | | Cerebrovasic Dis0，35，： | 1 |
| 11 | Refractive surgery survey 2001显示文摘 | Solomon KD Holzer MP Sandoval HP Vargas LG Werner L Vroman DT | 2002 | J Cataract Refract Surg2002，28，2： | 1 |
| 12 | Mechanical testing of cordierite porous ceramics using high temperature diametral compression 显示文摘 | SANDOVAL M L TALOU M H TOMBA MARTINEZ A G | 2010 | J Eur Ceram Soc2010，45，18： | 1 |
| 13 | Synthesis of hybrid (Ni-Mo) carbides/carbon-coated mesoporous materials and their catalytic properties for hydrocracking of intermediate paraffins (n-C8)显示文摘 | TORREA R D L I DOMINGUEZ J M MELO-BANDA J A RAMOS G C E SANDOVAL G | | 0，，1： | 1 |
| 14 | Surface and catalytic properties of Al2O3-ZrO2 solid solutions prepared by sol-gel methods显示文摘 | Dominguez J M Heranandez J L Sandoval G | 2000 | Applied Catalysis A:General2000，197，： | 1 |
| 15 | Simulation and Construction ofa Peed Control for a DC Series Motor 显示文摘 | SANTANA J NAREDO J L SANDOVAL F | 2002 | Mechatronics2002，12，910： | 1 |
| 16 | Enhanced proliferative effects of a baculovirus-produced fusion protein of insulin-like growth factor and alpha(1)-proteinase inhibitor and improved anti-elastase activity of the inhibitor with glutamate at position 35 1显示文摘 | SANDOVAL C CURTIS H CONGOTE L F | 2002 | Protein Eng2002，15，5： | 1 |
| 17 | Remodeling of the vessel wall after copper induced injury is highly attenuated in mice with a total deficiency of plasminogen activater inhibitor 1 显示文摘 | Ploplis VA Comelissen l Sandoval Cooper M J | 2001 | AmJ Pathol2001，158，1： | 1 |
| 18 | Acute fatty liver of pregnancy: a clinical study of 12 episodes in 11 patients显示文摘 | Reyes H Sandoval L Wainstein A | 1994 | Gut1994，35，： | 1 |
| 19 | Com- parison of visual outcomes, photopic contrast sensitivity, wavefront analysis, and patient satisfaction following cataract extraction and IOL implantation: aspheric vs spherical acrylic lenses显示文摘 | Sandoval H P de Fernandez C L Vroman D T | 2008 | Eye (Lond)2008，22，12： | 1 |
| 20 | Pirfenidone effectively reverses experimental liver fibrosis显示文摘 | García L Herndndez I Sandoval A | 2002 | J Hepatol2002，37，6： | 1 |
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