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| 1 | Genetic ancestry analysis in non-alcoholic fatty liver disease patients from Brazil and Portugal显示文摘AIM:To study the association between genetic ancestry,non-alcoholic fatty liver disease(NAFLD) metabolic characteristics in two cohorts of patients,from Brazil and Portugal. METHODS:We included 131 subjects from Brazil [(n = 45 with simple steatosis(S. Steatosis) and n = 86 with nonalcoholic steatohepatitis(NASH)] and 90 patients from Portugal(n = 66,S. Steatosis; n = 24,NASH). All patients had biopsy-proven NAFLD. In histologic evaluation NAFLD activity score was used to assess histology and more than 5 points defined NASH in this study. Patients were divided into two groups according to histology diagnosis:simple steatosis or non-alcoholic statohepatitis. Genetic ancestry was assessed using real-time polymerase chain reaction. Seven ancestry informative markers(AT3-I/D,LPL,Sb19.3,APO,FYNull,PV92,and CKMM) with the greatest ethnicgeographical differential frequencies(≥ 48%) were used to define genetic ancestry. Data were analyzed using R PROJECTS software. Ancestry allele frequencies between groups were analyzed by GENEPOP onlineand the estimation of genetic ancestry contribution was evaluated by ADMIX-95 software. The 5% alpha-error was considered as significant(P < 0.05). RESULTS:In the Brazilian sample,NASH was significantly more frequent among the elderly patients with diabetes(NASH 56 ± 1.1 years old vs S. Steatosis 51 ± 1.5 years old,P = 3.7 x 10-9),dyslipidemia(NASH 63% vs S. Steatosis 37%,P = 0.009),higher fasting glucose levels(NASH 124 ± 5.2 vs S. Steatosis 106 ± 5.3,P = 0.001) and Homeostatic Model of Assessment index > 2.5 [NASH 5.3(70.8%) vs S. Steatosis 4.6(29.2%) P = 0.04]. In the Portuguese study population,dyslipidemia was present in all patients with NASH(P = 0.03) and hypertension was present in a larger percentage of subjects in the S. Steatosis group(P = 0.003,respectively). The genetic ancestry contribution among Brazilian and Portuguese individuals with NASH was similar to those with S. Steatosis from each cohort(Brazilian cohort:P = 0.75; Portuguese cohort:P = 0.97). Nonetheless,the genetic ancestry contribution of the Brazilian and Portuguese population were different,and a greater European and Amerindian ancestry contribution was detected in the Portuguese population while a higher African genetic ancestry contribution was observed in Brazilian population of both NASH and S. Steatosis groups.CONCLUSION:There was no difference between the genetic ancestry contribution among Brazilian and Portuguese individuals with NASH and S. Steatosis from each cohort. | Lourianne Nascimento Cavalcante Jose Tadeu Stefano Mariana V Machado Daniel F Mazo Fabiola Rabelo Kiyoko Abe Sandes Flair Jose Carrilho Helena Cortez-Pinto Andre Castro Lyra Claudia P de Oliveira | 2015 | World Journal of Hepatology2015，7，10： | 2 |
| 2 | The inhibitory role of nitric oxide in the control of porcine and human sphincter of Oddi activity显示文摘 | Sand J Arvola P Jentti V | 1997 | Gut1997，41，： | 1 |
| 3 | Microflora of four fermented fish sauces显示文摘 | CRISAN E V SANDS A | 1975 | Applied Microbiology1975，29，1： | 1 |
| 4 | Persistent exit-site 'infection' in a peritoneal dialysis patient with chronic lymphocytic leukemia显示文摘 | Cornelis T van der Sande FM Winnepenninckx V | | 0，，06： | 1 |
| 5 | Fatty acid synthase drives the synthesis of phospholipids partitioning into detergent-resistant membrane microdomains显示文摘 | Johannes V Swinnen Paul P Van Veldhoven Leen Timmermans Ellen De Schrijver Koen Brusselmans Frank Vanderhoydonc Tine Van de Sande Hannelore Heemers Walter Heyns Guido Verhoeven | 2003 | Biochemical and Biophysical Research Communications2003，，4： | 1 |
| 6 | A large-scale replication study identifies TNIP1,PRDM1,JAZF1,UHRF1 BP1 and IL10 as risk loci for systemic lupus erythematosus显示文摘 | Gateva V Sanding JK Hom G | 2009 | Nat Genet2009，41，11： | 1 |
| 7 | Directly Observed Therapy for the Treatment of People with Human Immunode?ciency Virus Infection:A Work in Progress显示文摘 | Mitty J Stone V Sands M | 2002 | Clinical Infectious Diseases2002，34，7： | 1 |
| 8 | 显示文摘 | Liu H B Sande J B V | 1999 | J Mater Res1999，14，7： | 1 |
| 9 | Fibronectin promotes calcium signaling by interferongamma in human neutrophils via G-protein and sphingosine kinase-dependent mechanisms显示文摘 | Vas V Algerags Sand K L | 2001 | Cell Commun Adhes2001，8，3： | 1 |
| 10 | Pd/C-catalyzed transfer-hydrogenation of benzaldehydes to benzyl alcohols using potassium formate as the selective hydrogen donor显示文摘 | Baidossi M Joshi A V Mukhopadhyay Sand Yoel | 2004 | Synthetic Communications2004，34，4： | 1 |
| 11 | On Producing High-Spatial Resolution Composition Profiles via Scanning Transmission Electron Microscopy 显示文摘 | Hall E L Imeson D Vander sande J B V | 1981 | Phi Mag1981，43，： | 1 |
| 12 | Cost savings associated with post-thyroidectomy parathyroid hormone levels显示文摘 | Cote V Sands N Hier MP | | 0，，2： | 1 |
| 13 | Activated T helper 1 and T helper 2 cells differentially express the beta-2-adrenergic recepto:A mechanism for selective modulation of T helper 1 cell cytokine production显示文摘 | Baker R Sandes V | 1997 | J Immunol1997，159，12： | 1 |
| 14 | Surface state of Inconel 718 ultrasonic shot peened:Effect of processing time,material and quantity of shot balls and distance from radiating surface to sample显示文摘 | Sandá A Garcia Navas V Gonzalo O | 2011 | Materials and Design2011，32，： | 1 |
| 15 | Sodium,blood pressure and cardiovascular pathology:is it all volaemia显示文摘 | Kooman JP der Sande FM v Leunissen KM | | 0，，： | 1 |
| 16 | Second phase formation in melt-spun Mg-Ca-Zn alloys显示文摘 | Jardim P M Solórzano G Sande J B V | | 0，，： | 1 |
| 17 | Mature CD8^+ T lymphocyte response to viral infection during fetal life显示文摘 | Marchant A Appay V Van Der Sande M | 2003 | J Clin Invest2003，111，11： | 1 |
| 18 | An improved model for predicting the dynamic behaviour of adsorption systems显示文摘 | Sand S M Tribes V | 1996 | Applied Thermal Engineering1996，16，2： | 1 |
| 19 | Effects of transforming growth factor beta-1 on growth-regulatory genes in tumor derived human oral keratinocytes显示文摘 | Paterson IC Patel V Sand JR | 1995 | Br J Cancer1995，72，4： | 1 |
| 20 | Clustering and fighting in two-party crowds: Simulating the approach- avoidance conflict 显示文摘 | W Jager R Popping and H V D Sande | 2001 | Journal of Artificial Societies and Social Simulations2001，4，3： | 1 |
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