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| 1 | Effect of Ocimum sanctum on the development of protective immunity against Salmonella typhimurium infection through cytokines显示文摘Objective:To investigate the protective role of Ocimum sanctum(O.sanctum) leaves against Salmonella typhim.urium(S.typhimurium) infection in rats by inducing TNF-α,IFN-γ& IL-2 cytokines.Methods:Wistar albino rats were fed with aqueous extract of 0.sanctum leaves using 250 mg/kg body weight dose once a day for 20 consecutive days.Control rats were fed with placebo.Rats were infected with LD50 dose of 5.typhimurium infection and monitored for their survival.Bacterial blood burden in both the groups was compared and numbers of activated peritoneal macrophages were counted.Concentration of TNF-α,IFN-γand IL-2 cytokines in serum during different time intervals was assayed by sandwich ELISA.Results:Rats of control group showed a high mortality rate and had higher bacterial blood burden when compared with O.sanctum extract fed rats.There was a significant increase in the number of S.typhimurium engulfed peritoneal macrophages in the peritoneal fluid of O.sanctum fed animals.The protective control against bacterial infection in O,sanctum fed rats was associated with elevated level of TNF-α,IFN-γand IL-2 cytokines in serum.Conclusions:These findings suggest that orally administered O.sanctum leaves extract effectively enhanced activation in macrophage and lymphocytes,depicted by the elevated serum concentration of TNF-α,IFN-γand IL-2 cytokines,leading to induce a protective resistance against Salmonella typhimurium infection. | Anjana Goel Sandeep Kumar Ashok Kumar Bhatia | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，9： | 2 |
| 2 | Testing of SoCs with hierarchical cores:common fallacies, test access op- timization, and test scheduling显示文摘 | Sandeep Kumar Goel Erik Jan Marinissen | 2009 | IEEE Transactions on Com- puters2009，58，3： | 1 |
| 3 | Spermatogonia-specific proteins expressed in prepubertal buffalo ( Bubalus bubalis ) testis and their utilization for isolation and in vitro cultivation of spermatogonia显示文摘 | Sandeep Goel Niranjan Reddy Suman Mandal Mayako Fujihara Sung-Min Kim Hiroshi Imai | 2010 | Theriogenology2010，，7： | 1 |
| 4 | A theoretical model for the flow behavior of commercial dual-phase steels containing metastable retained austenite: Part I. derivation of flow curve equations显示文摘 | Naresh C. Goel Sandeep Sangal Kris Tangri | 1985 | Metallurgical Transactions A1985，，11： | 1 |
| 5 | Spermatogonial stem cells(SSCs) in Buffalo(Bubalus bubalis)testis显示文摘 | Ranjeet Singh Mahla Niranjan Reddy Sandeep Goel | 2012 | Buffalo Spermatogonial Stem Cells2012，7，4： | 1 |
| 6 | Immunomodulating property of Ocimum sanctum by regulating the IL-2 production and its mRNA expression using rat's splenocytes显示文摘Objective:To investigate the regulatory effect of aqueous extract of leaves of Ocimum sanctum on IL-2 cytokine production in vivo and in vitro,and the effect of leaves extract on general blood picture including T& B lymphocytes.Methods:For in vivo studies albino Wistar rats were treated with aqueous crude leaves extract of Ocimum sanctum for 20 consecutive days.Spleen cells were harvested and assayed for IL-2 production by using sandwich enzyme-linked immunosorbent assay(ELISA) and mRNA expression methods.For in vitro study aqueous Ocimum sanctum leaves extract= in different concentrations(25-500μ/mL) was added into culture plates containing ConA stimulated splenocytes.To study the overall effect on blood picture,density gradient purified lymphocytes analysis and conventional methodology for total and differential leukocyte count and hemoglobin level were also done.Results:It indicated that the rats treated with Ocimum sanctum leaves extract had significantly enhanced(P<0.001) ability of spleen cells to secrete IL-2.Investigation in vitro also showed regulation of IL-2 production.Blood study exhibited leucocytosis and augmentation of T& B lymphocytes by 25%approximately.4-5%increase in Hemoglobin value was also noticed.Conclusion:Aqueous Ocimum sanctum leaves extract may have stimulatory effect on T & B lymphocytes particularly on Th 1 subset of lymphocytes as shown by enhancement in IL-2 production. | Anjana Goel Dilip Kumar Singh Sandeep Kumar Ashok Kumar Bhatia | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，1： | 1 |
| 7 | Large chest wall fibromatosis with challenging treatment plan显示文摘The primary mode of treatment for desmoid tumors is surgical excision.However,high recurrence rates(39-79%)have been reported when surgery is used alone.The role of adjuvant radiotherapy after surgical resection of primary disease is controversial and should be based on a balanced discussion of potential morbidity from radiotherapy and local recurrence.In this patient,the maximum dimension of tumor was 21 cm.This is a larger chest wall fibromatosis than has been reported thus far,to the best of our knowledge.In this case,post-operative margins were free,but in view of the large initial tumor size and potential morbidity in case of any future locoregional recurrence,post-operative adjuvant external beam radiation was delivered.An image guided intensity modulated radiotherapy technique was chosen to spare adjacent breast and lung parenchyma,and tolerance of these structures was well respected.This case provides insight into this treatment approach. | Rashi Agrawal Prekshi Choudhary Arun Kumar Goel Vaishali Zamre Sandeep Agarwal Dinesh Singh | 2017 | Journal of Cancer Metastasis and Treatment2017，3，1： | 0 |
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