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| 1 | Feeder-free maintenance of hESCs in mesenchymal stem cell-conditioned media: distinct requirements for TGF-β and IGF-Ⅱ显示文摘 | Rosa Montes Gertrudis Ligero Laura Sanchez Purificacidn Catalina Teresa de la Cueva Ana Nieto Gustavo J Melen Ruth Rubio Javier Garcia-Castro Clara Bueno Pablo Menendez | 2009 | Cell Research2009，19，6： | 7 |
| 2 | Incretins and selective renal sodium-glucose co-transporter 2 inhibitors in hypertension and coronary heart disease显示文摘Hyperglycemia is associated with an increased risk of cardiovascular disease,and the consequences ofintensive therapy may depend on the mechanism of the anti-diabetic agent(s)used to achieve a tight control.In animal models,stable analogues of glucagon-like peptide-1(GLP-1)were able to reduce body weight and blood pressure and also had favorable effects on ischemia following coronary reperfusion.In a similar way,dipeptidyl peptidase IV(DPPIV)showed to have favorable effects in animal models of ischemia/reperfusion.This could be due to the fact that DPPIV inhibitors were able to prevent the breakdown of GLP-1 and glucose-dependent insulinotropic polypeptide,but they also decreased the degradation of several vasoactive peptides.Preclinical data for GLP-1,its derivatives and inhibitors of the DPPIV enzyme degradation suggests that these agents may be able to,besides controlling glycaemia,induce cardio-protective and vasodilator effects.Notwithstanding the many favorable cardiovascular effects of GLP-1/incretins reported in different studies,many questions remain unanswered due the limited number of studies in human beings that aim to examine the effects of GLP-1 on cardiovascular endpoints.For this reason,long-term trials searching for positive cardiovascular effects are now in process,such as the CAROLINA and CARMELINA trials,which are supported by small pilot studies performed in humans(and many more animal studies)with incretin-based therapies.On the other hand,selective renal sodium-glucose co-transporter 2 inhibitors were also evaluated in the prevention of cardiovascular outcomes in type 2 diabetes.However,it is quite early to draw conclusions,since data on cardiovascular outcomes and cardiovascular death are limited and long-term studies are still ongoing.In this review,we will analyze the mechanisms underlying the cardiovascular effects of incretins and,at the same time,we will present a critical position about the real value of these compounds in the cardiovascular system and its protection. | Ramiro A Sanchez Hugo Sanabria Cecilia de los Santos Agustin J Ramirez | 2015 | World Journal of Diabetes2015，6，11： | 5 |
| 3 | Non-steroidal anti-inflammatory drugs and risk of neoplastic progression in Barrett’s oesophagus: a prospective study显示文摘 | Thomas L Vaughan Linda M Dong Patricia L Blount Kamran Ayub Robert D Odze Carissa A Sanchez Peter S Rabinovitch Brian J Reid | 2005 | Lancet Oncology2005，，12： | 2 |
| 4 | Effects of organic pollution on transplanted aquatic bryophytes 显示文摘 | MARTINE Abaigar J NUNEZ Olivera E SANCHEZ Diaz M | 1993 | J Bryol1993，17，4： | 2 |
| 5 | Predictors of progression in Barrett’s esophagus II: baseline 17p (p53) loss of heterozygosity identifies a patient subset at increased risk for neoplastic progression显示文摘 | Brian J Reid Laura J Prevo Patricia C Galipeau Carissa A Sanchez Gary Longton Douglas S Levine Patricia L Blount Peter S Rabinovitch | 2001 | The American Journal of Gastroenterology2001，，10： | 2 |
| 6 | A human ESC model for MLL-AF4 leukemic fusion gene reveals an impaired early hematopoietic-endothelial specification显示文摘MLL-AF4 熔化基因是在在婴儿的高风险的尖锐成淋巴细胞的白血病的一个特点 genomic 错误。尽管 MLL-AF4 在人的开发期间出生前地产生,这很好被建立,它在在 utero 的造血的开发的效果仍然保持未经勘探。我们创造了一个人特定的细胞的系统在 MLL-AF4-expressing 人的胚胎的干细胞(hESCs ) 学习早 hemato-endothelial 开发。介绍的功能的研究,同种细胞的分析和基因表示表明在 hESCs 的 MLL-AF4 的那表情有 phenotypic,功能并且基因表示影响。MLL-AF4 在 hESCs 充当全球 transcriptional 使活跃之物和 homeobox 基因表示的一个积极管理者。机能上地, MLL-AF4 从 hESCs 提高 hemogenic 先锋的说明,但是强烈损害进一步造血的承诺赞成 endothelial 房间命运。MLL-AF4 hESCs transcriptionally 被告知向对 endothelial 成熟敏感的 hemogenic 先锋区分,由联系到 vascular-endothelial 功能和早造血作用的主人基因的显著 upregulation 思考了。而且,我们报导那 MLL-AF4 表情不是足够的转变导出 hESC 的造血的房间。这个工作说明 hESCs 怎么可以提供唯一的卓见进人的开发并且推进我们理解白血病的熔化基因,知道出生前地产生,调整人的胚胎的造血的说明。 | Clara Bueno Rosa Montes Gustavo J Melen Verdnica Ramos-Mejia Pedro J Real Ver6nica Ayllo'n Laura Sanchez Gertmdis Ligero Inmaculada Gutierrez-Aranda Agustin F Femfindez Mario F Fraga Inmaculada Moreno-Gimeno Deborah Btlrks Maria del Carmen Plaza-Calonge Juan C Rodriguez-Manzaneque Pablo Menendez | 2012 | Cell Research2012，22，6： | 2 |
| 7 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S Cardozo Pelaez F | | 0，，： | 2 |
| 8 | On the numerical solution of the point reactor kinetics equations by generalized Runge-Kutta methods显示文摘 | SANCHEZ J | 1989 | Nucl Sci Eng1989，103，： | 1 |
| 9 | Bioshale FP6 European project: exploiting black shale ores using biotechnologies? 显示文摘 | D'HUGUES P NORRIS P R HALLBERG K SANCHEZ F LANGWALDT J GROTOWSKI A CHMIELEWSKI T GROUDEV S Bioshale consortium | 2007 | Minerals Engineering2007，21，： | 1 |
| 10 | Assessment of metal contamination in donana national park (spain) using crayfish (proeamburus elarkia) 显示文摘 | Sanchez Lopez F J Gil Garcia M D Martinez Vidal J | 2004 | Environmental Monitoring and Assessment2004，，93： | 1 |
| 11 | Manipulation of dopamine D1-like receptor activation in the rat medial prefrontal cortex alters stress- and cocaine-induced reinstatement of conditioned place preference behavior显示文摘 | Sanchez C J Bailie TM Wu WR | 2003 | Neuroscience2003，119，： | 1 |
| 12 | CO2 Emissions Embodied in International Trade:Evidence for Spain显示文摘 | Sanchez C J Duarte R | 2004 | Energy Policy2004，32，18： | 1 |
| 13 | Tourism image,evaluation variable and after purchase behaviour:interrelationship显示文摘 | Bigne J E Sancbez M I Sanchez J | 2001 | Toursim Management2001，22，： | 1 |
| 14 | Differentiating between malignant and idiopathic pleural effusions:the value of diagnostic procedures显示文摘 | Aleman C Sanchez L Alegre J | 2007 | QJM2007，100，： | 1 |
| 15 | The interaction of p62 with RIP links the atypical PKCs to NF-kappaB activation显示文摘 | Sanz L Sanchez P Lallena M J | 1999 | EMBO J1999，18，11： | 1 |
| 16 | Hot isostatic pressing of ultrafine tungsten carbide-cobalt hardmetal 显示文摘 | AZCONA I ORDONEZ A SANCHEZ J M | 2002 | Journal of Materials Science2002，37，： | 1 |
| 17 | Nitrogen and phosphorus removal from urban wastewater by the mieroalga Scenedesmus obliquus显示文摘 | MARTNEZ M E SANCHEZ S JIMENEZ J M | 2000 | Bioresource Technology2000，73，3： | 1 |
| 18 | Modularity Flexibility, and Knowledge Management in Product and Organization Design 显示文摘 | SANCHEZ R MAHONEY J | 1996 | Strategic Management Journal1996，17，： | 1 |
| 19 | Aluminium foams as structured supports fur volatile organic compounds( VOCs )oxidation显示文摘 | Sanz O Echave F J Sanchez M | 2008 | Applied Catalysis: Genera2008，340，1： | 1 |
| 20 | Interactions between poly(ethylene oxide) -based surfactants and transition metal alkoxides:Their role in the templated construction of mesostructured hybrid organic-inorganic composites显示文摘 | Galo J de A A Soler-IlLia C1ément Sanchez | 2000 | New Journal of Chemistry2000，24，7： | 1 |
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