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您的检索式：作者名="Samuel S.Shin"
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| 1 | Targeting α7 nicotinic acetylcholine receptors: a future potential for neuroprotection from traumatic brain injury显示文摘Traumatic brain injury(TBI)poses a significant socioeconomic burden in the world.The long lasting consequences in cognitive impairments are often underreported and its mechanisms are unclear.In this perspective,cholinergic dysfunction and therapeutic strategy targeting this will be reviewed.Novel agents that can target specific subtype of acetylcholine receptors have been developed over the recent years and | Samuel S.Shin C.Edward Dixon | 2015 | Neural Regeneration Research2015，10，10： | 3 |
| 2 | Optimizing CT for the evaluation of vestibular aqueduct enlargement:Inter-rater reproducibility and predictive value of reformatted CT measurements显示文摘Enlarged vestibular aqueduct(EVA), the most frequent identifiable cause of congenital hearing loss, is evaluated with high-definition multidetector CT in the axial plane. Our purpose was to determine which reformatted CT measurements are most reproducible. Seven multiplanar reformatted images were created for each of the 64 temporal bones in patients with EVA. Intraclass correlation coefficients(ICC) were used to assess inter-observer variability, and both linear regression and ROC analyses were used to compare the measurements with severity of hearing loss, as assessed by pure tone audiometry. All seven measurements had excellent inter-observer variability, with average-measure ICC ranging from 0.92 to 0.98. There was no statistically significant correlation between the radiologic degree of aqueduct enlargement and severity of hearing loss using any of the seven measurements; ROC analyses revealed areas under the curves ranging from 0.57 to 0.73. Optimal accuracy was obtained with a threshold of 1.75 mm as measured at the aqueductal aperture in the P€oschl plane, with sensitivity of 0.75 and specificity of0.63. Although the radiologic measurement may not serve as a reliable tool for assessing severity of EVA, P€oschl plane reformatting has proven to be better than conventional axial acquisition plane for identifying patients with clinically significant hearing loss. | Misun Hwang Ryan Marovich Samuel S.Shin David Chi Barton F.Branstetter IV | 2015 | Journal of Otology2015，10，1： | 2 |
| 3 | Extracellular matrices, artificial neural scaffolds and the promise of neural regeneration显示文摘Over last 20 years, extracellular matrices have been shown to be useful in promoting tissue regeneration. Recently, they have been used and have had success in achieving neurogenesis. Recent developments in extracellular matrix design have allowed their successful in vivo incorporation to engender an environment favorable for neural regeneration in animal models. Promising treatments under investigation include manipulation of the intrinsic extracellular matrix and incorporation of engineered naometer-sized scaffolds through which inhibition of molecules serving as barriers to neuroregeneration and delivery of neurotrophic factors and/or cells for successful tissue regeneration can be achieved. Further understanding of the changes incurred within the extracellular matrix following central nervous system injury will undoubtedly help design a clinically efficacious extracellular matrix scaffold that can mitigate or reverse neural degeneration in the clinical setting. | Christian B.Ricks Samuel S.Shin Christopher Becker Ramesh Grandhi | 2014 | Neural Regeneration Research2014，9，17： | 1 |
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